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what is the prototype nsaid

by Dr. Esther Dietrich Published 3 years ago Updated 2 years ago

The prototype is aspirin; hence these compounds are often referred to as aspirin-like drugs. They are also frequently designated as nonsteroidal anti-inflammatory drugs (NSAIDs).Feb 25, 2018

Precautions

NSAIDs are usually used for the treatment of acute or chronic conditions where pain and inflammation are present. NSAIDs are generally used for the symptomatic relief of the following conditions: In addition, when used in combination with paracetamol the analgesic effect on post-operative pain has been proven to be improved.

What are NSAIDs and why are they used?

Morphineis the prototype of opioid analgesics[1][3] Propranololis the prototype of the beta blockers[4][5] Chlorpromazineis the prototypical phenothiazineantipsychotic[6][7] Imipramineis the prototypical tricyclic antidepressant, and itself a derivative of chlorpromazine[6][8]

What is the prototype drug for opioid analgesics?

^ a b c d "NSAIDs may cause rare kidney problems in unborn babies". U.S. Food and Drug Administration. 21 July 2017. Retrieved 15 October 2020. This article incorporates text from this source, which is in the public domain.

Do NSAIDs cause rare kidney problems in unborn babies?

What is the prototype drug for NSAIDs?

Aspirin (acetylsalicylic acid) is the prototype of the salicylates and other NSAIDs (Table 36–1).

What is a prototype of a medication?

In pharmacology and pharmaceutics, a prototype drug is an individual drug that represents a drug class – group of medications having similar chemical structures, mechanism of action and mode of action.

What is the prototype of aspirin?

Aspirin is a prototype of non-steroidal anti-inflammatory drugs (NSAIDs), and member of the family of salicylates that have in common salicylic acid as the active agent. Salicylic acid is composed of a benzene ring and two radicals, one hydroxyl and one carboxyl.

What is the prototype for acetaminophen?

The prototype is aspirin; hence these compounds are often referred to as aspirin-like drugs. All aspirin-like drugs are antipyretic, analgesic, and anti-inflammatory, but there are important differences in their activities. For example, acetaminophen is antipyretic and analgesic but is only weakly anti-inflammatory.

What is a prototype drug example?

The prototype, often the first drug of a particular drug class to be developed, is usually the standard with which newer drugs in the class are compared. For example, morphine is the prototype of the opioid analgesics and penicillin is the prototype of the beta-lactam antibacterial drugs.

What do you understand by prototype?

Prototyping is an experimental process where design teams implement ideas into tangible forms from paper to digital. Teams build prototypes of varying degrees of fidelity to capture design concepts and test on users. With prototypes, you can refine and validate your designs so your brand can release the right products.

What is the prototype of metformin?

Metformin—Prototype for the Biguanide Class of Insulin Sensitizers.

What is the prototype of sedative?

The barbitu- rates are the prototype drug and constitute the principal member of the sedative/hypnotic class if the benzodiazepines are not included. The benzo- diazepines belong in the class of sedative/hypnotic drugs if actual pharma- cological properties are used for classification.

What is a prototype in nursing?

Abstract. A prototype is being developed for a computerized nursing information system that will not only record, transmit, and retrieve information but also aid clinical decision-making and facilitate research and evaluation.

What is the prototype for guaifenesin?

Codeine/guaifenesin (Robitussin AC) The prototype antitussive, codeine, has been used successfully in some chronic cough and induced-cough models, but scant clinical data exist for upper respiratory tract infections.

What is the prototype of ceftriaxone?

The present study tested the hypothesis that ceftriaxone, a prototype beta-lactam antibiotic, can prevent the development of opioid-induced hyperalgesia (OIH) in mice. Repeated morphine administration produced mechanical allodynia and thermal hyperalgesia, signs of OIH, and reduced spinal GLT-1 expression in mice.

What are 3 types of analgesics?

There are three broad categories of analgesic medications: (1) nonopioid analgesics, which includes the nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, dipyrone, and others; (2) a diverse group of drugs known as the "adjuvant analgesics," which are defined as "drugs that have primary indications other ...

When did NSAIDs start?

First used in 1960, the term served to distance these medications from steroids, which were particularly stigmatised at the time due to the connotations with anabolic steroid abuse. NSAIDs work by inhibiting the activity of cyclooxygenase enzymes ( COX-1 or COX-2 ).

What are NSAIDs used for?

NSAIDs, when used in combination with SSRIs, increases the risk of internal bleeding and brain hemorrhages. Various widely used nonsteroidal anti-inflammatory drugs (NSAIDs) enhance endocannabinoid signaling by blocking the anandamide-degrading membrane enzyme fatty acid amide hydrolase ( FAAH ).

What are the reactions to NSAIDs?

A variety of allergic or allergic-like NSAID hypersensitivity reactions follow the ingestion of NSAIDs. These hypersensitivity reactions differ from the other adverse reactions listed here which are toxicity reactions, i.e. unwanted reactions that result from the pharmacological action of a drug, are dose-related, and can occur in any treated individual; hypersensitivity reactions are idiosyncratic reactions to a drug. Some NSAID hypersensitivity reactions are truly allergic in origin: 1) repetitive IgE -mediated urticarial skin eruptions, angioedema, and anaphylaxis following immediately to hours after ingesting one structural type of NSAID but not after ingesting structurally unrelated NSAIDs; and 2) Comparatively mild to moderately severe T cell -mediated delayed onset (usually more than 24 hour), skin reactions such as maculopapular rash, fixed drug eruptions, photosensitivity reactions, delayed urticaria, and contact dermatitis; or 3) far more severe and potentially life-threatening t-cell-mediated delayed systemic reactions such as the DRESS syndrome, acute generalized exanthematous pustulosis, the Stevens–Johnson syndrome, and toxic epidermal necrolysis. Other NSAID hypersensitivity reactions are allergy-like symptoms but do not involve true allergic mechanisms; rather, they appear due to the ability of NSAIDs to alter the metabolism of arachidonic acid in favor of forming metabolites that promote allergic symptoms. Afflicted individuals may be abnormally sensitive to these provocative metabolites or overproduce them and typically are susceptible to a wide range of structurally dissimilar NSAIDs, particularly those that inhibit COX1. Symptoms, which develop immediately to hours after ingesting any of various NSAIDs that inhibit COX-1, are: 1) exacerbations of asthmatic and rhinitis (see aspirin-induced asthma) symptoms in individuals with a history of asthma or rhinitis and 2) exacerbation or first-time development of wheals or angioedema in individuals with or without a history of chronic urticarial lesions or angioedema.

What are the two types of NSAIDs?

There are two types of NSAIDs available: non-selective and COX-2 selective.

Which NSAIDs cause photosensitivity?

Photosensitivity is a commonly overlooked adverse effect of many of the NSAIDs. The 2-arylpropionic acids are the most likely to produce photosensitivity reactions, but other NSAIDs have also been implicated including piroxicam, diclofenac, and benzydamine.

Can NSAIDs cause kidney disease?

NSAIDs are also associated with a fairly high incidence of adverse drug reactions ( ADRs) on the kidney and over time can lead to chronic kidney disease. The mechanism of these kidney ADRs is due to changes in kidney blood flow. Prostaglandins normally dilate the afferent arterioles of the glomeruli.

When to use prostaglandins in neonates?

In a more specific application, the reduction in prostaglandins is used to close a patent ductus arteriosus in neonates if it has not done so physiologically after 24 hours. NSAIDs are useful in the management of post-operative dental pain following invasive dental procedures such as dental extraction.

What is a prototype drug?

Jump to navigation Jump to search. In pharmacology and pharmaceutics, a prototype drug is an individual drug that represents a drug class – group of medications having similar chemical structures, mechanism of action and mode of action. Prototypes are the most important, and typically ...

What is the prototypical antimalarial agent?

Diphenhydramine (Benadryl) is the prototype ethanolamine antihistamine. Nifedipine is the prototype dihydropyridine calcium channel blocker. Chloroquine is the prototypical antimalarial agent.

What is a prototype drug?

A prototype drug is the first form of a drug or medication that is used to create alternative forms, states Drugs.com. Prototype drugs are also called lead agents, according to Virginia Commonwealth University. According to Weber State University, aspirin is a prototype drug that acts as an anti-inflammatory and analgesic or pain killer.

What are the two drugs that are similar to aspirin?

Drugs derived from the prototype drug aspirin include acetaminophen and ibuprofen. These are both aspirin-like drugs, although the specific benefits may differ. For example, acetaminophen has fewer side effects than aspirin, but it does not produce the same anti-inflammatory effects.

Is aspirin an anti-inflammatory?

According to Weber State University, aspirin is a prototype drug that acts as an anti-inflammatory and analgesic or pain ki ller. This class of drugs provides relief from pain, but does not address the cause of the pain.

image

What Are Nonsteroidal Anti-Inflammatory Agents Used for?

Ibuprofen is used to help relieve mild to moderate pain. When used with an opioid (such as morphine), it may be used to relieve moderate to severe pain. It is also used to reduce fever.

May Treat: Dysmenorrhea · Fever · Headache disorder · Juvenile idiopathic arthritis · Osteoarthritis and more

Brand Names: Caldolor · Advil · Advil Liqui-Gel · Children's Ibuprofen · IBU-200 and more

Drug Class: NSAID Analgesics (COX Non-Specific) - Propionic Acid Derivatives

Availability: Prescription sometimes needed

Pregnancy: Do not use. This medication may be harmful to an unborn child.

May Treat: Dysmenorrhea · Fever · Headache disorder · Juvenile idiopathic arthritis · Osteoarthritis and more

Brand Names: Caldolor · Advil · Advil Liqui-Gel · Children's Ibuprofen · IBU-200 and more

Drug Class: NSAID Analgesics (COX Non-Specific) - Propionic Acid Derivatives

Availability: Prescription sometimes needed

Pregnancy: Do not use. This medication may be harmful to an unborn child.

Lactation: Does not adversely affect lactation

Alcohol: Limit intake while taking this medication

Driving: May cause drowsiness or dizziness. Use caution

Precautions

  • Watch for bleeding, heart attack or stroke signs.
  • Avoid use in pregnancy from 20 weeks until birth
  • For suspension, drops products : Do not use for more than 10 days unless directed.

  • Watch for bleeding, heart attack or stroke signs.
  • Avoid use in pregnancy from 20 weeks until birth
  • For suspension, drops products : Do not use for more than 10 days unless directed.
  • For suspension, oral products : Shake well & measure with dosing spoon/cup/syringe. Unless MD directs, do not use in kids less than 2. Call Dr if you have black stools or stomach pain.
  • For tablet products : Before use, important to read the Medication Guide. Best to take with food to lessen stomach upset. Take with 8 oz. liquid. Do not lie down for 10min. Do not take more than package label recommends. May make you drowsy or dizzy. Drive with caution. Limit alcohol consumption and stop using tobacco. Low dose daily aspirin ok Ask MD about other NSAIDs.
  • For tablet, chewable products : Chew medicine completely before swallowing.
  • For vial products : Call Dr if heartburn, or swallowing/stomach pain. May make you dizzy. Use caution when driving. Review all drugs you are taking with your doctor. No aspirin-like meds. Ask MD about daily aspirin.

What Are The Differences Between Nonsteroidal Anti-Inflammatory Agents?

List of Common NSAIDs

Are Nonsteroidal Anti-Inflammatory Agents Safe?

What Are The Side Effects of Nonsteroidal Anti-Inflammatory Agents?

  • NSAIDs are used to treat mild-to-moderate pain that arises from a wide range of conditions such as headaches, menstruation, migraines, osteoarthritis or rheumatoid arthritis, sprains and strains, and toothache. Aspirin is a NSAID that is used in small doses to lower the risks of having a heart attack or a strokecaused by a blood clot. It may also b...
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Overview

  • NSAIDs may be grouped according to their preference for COX-1 and COX-2 enzymes. Those that favor COX-1 are more likely to cause gastrointestinal side effects. Those that favor COX-2 have a higher risk of cardiovascular effects but less gastrointestinal effects. Higher dosages of NSAIDs tend to result in more COX-2 enzyme inhibition (and more cardiovascular side effects), even in t…
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Medical uses

  • *Ranked in order from the least COX-2 activity to the highest within that group. Note that selectivity rankings vary depending on resources used. This table is based on a best effort accumulation of data.
See more on drugs.com

Contraindications

  • NSAIDs are one of the most widely prescribed group of medicines; however, they are associated with some serious side effects. NSAIDs can increase your risk of a fatal heart attack or stroke. The risk increases the higher the dosage and the longer the length of time you remain on an NSAID for. People with pre-existing heart disease are more at risk and certain NSAIDs, such as d…
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Adverse effects

  • NSAIDs can potentially cause a range of side effects, especially when used at higher than recommended dosages for long periods of time. Gastrointestinal side effects that may occur include bloating, diarrhea, constipation, irritation of the lining of the stomach, nausea or vomiting. NSAIDs may also affect kidney function and reduce how quickly blood flows through the kidneys…
See more on drugs.com

Mechanism of action

Non-steroidal anti-inflammatory drugs (NSAID) are members of a therapeutic drug class which reduces pain, decreases inflammation, decreases fever, and prevents blood clots. Side effects depend on the specific drug, its dose and duration of use, but largely include an increased risk of gastrointestinal ulcers and bleeds, heart attack, and kidney disease.

Classification

NSAIDs are often suggested for the treatment of acute or chronic conditions where pain and inflammation are present. NSAIDs are generally used for the symptomatic relief of the following conditions:
• Osteoarthritis
• Rheumatoid arthritis

Pharmacokinetics

NSAIDs may be used with caution by people with the following conditions:
• Irritable bowel syndrome (IBS)
• Persons who are over age 50, and who have a family history of gastrointestinal (GI) problems
• Persons who have had previous gastrointestinal problems from NSAID use

History

The widespread use of NSAIDs has meant that the adverse effects of these drugs have become increasingly common. Use of NSAIDs increases risk of a range of gastrointestinal (GI) problems, kidney disease and adverse cardiovascular events. As commonly used for post-operative pain, there is evidence of increased risk of kidney complications. Their use following gastrointestinal surgery remains controversial, given mixed evidence of increased risk of leakage from any bowel

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      Metadata
      Bindings
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      Backtrace
      • 15. /vendor/outl1ne/nova-menu-builder/src/helpers.php:32
      • 17. /vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. /vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:45
      • 19. /vendor/laravel/framework/src/Illuminate/Routing/Route.php:261
      • 20. /vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
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      Metadata
      Bindings
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      Backtrace
      • 19. /vendor/outl1ne/nova-menu-builder/src/Models/Menu.php:35
      • 20. /vendor/outl1ne/nova-menu-builder/src/helpers.php:33
      • 22. /vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 23. /vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:45
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      Metadata
      Backtrace
      • 24. /vendor/outl1ne/nova-menu-builder/src/Models/Menu.php:35
      • 25. /vendor/outl1ne/nova-menu-builder/src/helpers.php:33
      • 27. /vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      Metadata
      Bindings
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      Backtrace
      • 14. /app/View/Composers/SidebarView.php:22
      • 15. /app/View/Composers/SidebarView.php:12
      • 16. /vendor/laravel/framework/src/Illuminate/View/Concerns/ManagesEvents.php:124
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      Metadata
      Bindings
      • 0. 25919
      Backtrace
      • 21. view::2dd102cf0462e89a4d4d8bc77355d767652bf9aa:15
      • 23. /vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:108
      • 24. /vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 25. /vendor/livewire/livewire/src/ComponentConcerns/RendersLivewireComponents.php:69
      • 26. /vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:61
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