What is UniProt KnowledgeBase?
UniProt Knowledgebase (UniProtKB) is the central access point for extensive curated protein information, including function, classification, and cross- reference. The database is divided into two section UniProtKB/Swiss-Prot which is manually curated and UniProtKB/TrEMBL which is automatically maintained.
What's new at UniProt?
The new UniProt website is here! Take me to UniProt BETA When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. More... The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome.
What is the'basket'in the UniProtKB?
When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. More... The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome.
What is UniProt database?
The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. The UniProt databases are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), and the UniProt Archive (UniParc).
What are the components of UniProt database?
UniProt is comprised of four major components, each optimized for different uses: the UniProt Knowledgebase, the UniProt Reference Clusters, the UniProt Archive and the UniProt Metagenomic and Environmental Sequences database.
What is UniProt in bioinformatics Slideshare?
• UniProt is the universal protein resource • A central repository (storage area) of protein data • UniProt is a comprehensive (large scope) • high-quality • freely accessible database • www.uniprot.org 3.
Is UniProt protein database?
UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived from the research literature.
How many sequences are in UniProt?
UniProt release 2020_04 contains over 189 million sequence records (Figure 1), with >292 000 proteomes, the complete set of proteins believed to be expressed by an organism, originating from completely sequenced viral, bacterial, archaeal and eukaryotic genomes available through the UniProtKB Proteomes portal (https:// ...
Is UniProt a secondary database?
Hybrid databases and families of databases Many data resources have both primary and secondary characteristics. For example, UniProt accepts primary sequences derived from peptide sequencing experiments.
What is the difference between UniProt and Swiss-Prot?
Protein families and groups of proteins are continuously reviewed to keep up with current scientific findings. UniProtKB/TrEMBL is a computer-annotated (unreviewed) supplement to Swiss-Prot, which strives to gather all protein sequences that are not yet represented in Swiss-Prot.
Is UniProt a NCBI?
Apart from the UniProtKB-RefSeq mappings that the UniProt Consortium provides to NCBI, and that are reported in 'NCBI Reference Sequences (RefSeq)' section of RefSeq entry reports, NCBI also computes additional 'Related sequences', which can include UniProtKB proteins and are displayed in a separate section.
What is a UniProt number?
Last modified April 10, 2018. The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the proteome. It consists of the characters 'UP' followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.
What is PDB used for?
The PDB distributes coordinate data, structure factor files and NMR constraint files. In addition it provides documentation and derived data. The coordinate data are distributed in PDB and mmCIF formats.
What is UniRef in UniProt?
Results: The UniRef (UniProt Reference Clusters) provide clustered sets of sequences from the UniProt Knowledgebase (UniProtKB) and selected UniProt Archive records to obtain complete coverage of sequence space at several resolutions while hiding redundant sequences.
Who established SWISS-PROT?
SWISS-PROT (1) is an annotated protein sequence database, which was created at the Department of Medical Biochemistry of the University of Geneva and has been a collaborative effort of the Department and the European Molecular Biology Laboratory (EMBL), since 1987.
The uni prot knowledgebase
1. [email protected] Swiss-Prot group, Geneva SIB Swiss Institute of Bioinformatics The UniProt knowledgebase www.uniprot.org a hub of integrated protein data http://education.expasy.org/cours/Prague2011/
Editor's Notes
This Science cover clearly shows the well known discepancy between the amount of data and the amount of knowledge which are available.This is a first challenge …but there is a second one: how is to link the 2 together ?