how often can you give zofran iv

Precautions

Precautions

• General. ...
• Information for Patients. ...
• Drug Interactions. ...
• Carcinogenesis, Mutagenesis, Impairment of Fertility. ...
• Pregnancy. ...
• Pediatric Use. ...

How much Benadryl can you give IV push?

What happens if you push IV Zofran too fast? This drug is usually started 30 minutes before your chemotherapy treatment begins. Do not give this medication any faster than recommended or take more than the recommended dose because this may increase the chance of serious side effects such as blurred vision or slowed/irregular heartbeat.

What happens if you push IV Zofran too fast?

The general, researched-baked consensus of the past was that Zofran is relatively safe in all trimesters. However, now some people suggest otherwise.

How long is it safe to use Zofran?

Young children are advised to take 4 mg of Zofran ODT three times a day for one to two days after chemotherapy is finished. This is slightly different from adults, who are advised to take 8 mg two times a day for one to two days after completing chemotherapy.

How often can you take Zofran 4mg ODT?

How often can Zofran be given?

Adults—One 8-milligram (mg) film three times a day. Children—Use and dose must be determined by your doctor.Feb 1, 2022

How long should I wait between doses of Zofran?

The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor.

How much Zofran can you give IV?

The recommended adult intravenous dosage of ZOFRAN is three 0.15-mg/kg doses up to a maximum of 16 mg per dose [see CLINICAL PHARMACOLOGY]. The first dose is infused over 15 minutes beginning 30 minutes before the start of emetogenic chemotherapy.

Can Zofran be given IV piggyback?

How to use Ondansetron 8 Mg/50 Ml In 5 % Dextrose Intravenous Piggyback. To prevent nausea from chemotherapy, ondansetron is mixed in a solution and given by injection into a vein as directed by your doctor, usually over 15 minutes. This drug is usually started 30 minutes before your chemotherapy treatment begins.

Can you take two Zofran?

To protect against delayed or prolonged emesis after the first 24 hours, oral or rectal treatment with Zofran may be continued for up to 5 days after a course of treatment. The recommended dose for oral administration is 8 mg to be taken twice daily.

Does Zofran make you sleepy like Phenergan?

Zofran is an antiemetic (anti-nausea and vomiting) and selective 5-HT3 receptor antagonist and Phenergan is an antihistamine. Side effects of Zofran and Phenergan that are similar include dizziness, drowsiness, constipation, and blurred vision.

What happens if you push IV Zofran too fast?

Do not give this medication any faster than recommended or take more than the recommended dose because this may increase the chance of serious side effects such as blurred vision or slowed/irregular heartbeat.

How long does Zofran take to work through IV?

Zofran (ondansetron) begins to work within about 30 minutes. It reaches peak blood concentrations in about 2 hours. Zofran's effects can last 8 to 12 hours.Apr 27, 2020

How long does it take for IV Zofran to kick in?

Ondansetron is an anti-sickness medicine. It will start to work within 1-2 hours.Jan 14, 2020

Do you dilute Zofran IV push?

All intravenous doses should be diluted in 50-100 ml of saline or other compatible infusion fluid (see section 6.6) and infused over 15 minutes. In patients 75 years of age or older, the initial intravenous dose of Ondansetron should not exceed 8 mg.

What is the half life of IV Zofran?

infusion. The mean elimination half-life was 4.1 hours. Systemic exposure to 32 mg of ondansetron was not proportional to dose as measured by comparing dose-normalized AUC values to an 8-mg dose. This is consistent with a small decrease in systemic clearance with increasing plasma concentrations.

How long does it take to dilution Zofran?

Infuse intravenously over 15 minutes beginning 30 minutes before the start of emetogenic chemotherapy and then repeat 4 and 8 hours after the first dose.

How much sodium chloride is in Zofran?

Dilution of Zofran Injection in 50 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection is required before administration to adult and pediatric patients for the prevention of nausea and vomiting associated with emetogenic chemotherapy.

How long before cisplatin is ondansetron given?

Patients received the first dose of ondansetron or metoclopramide 30 minutes before cisplatin. Two additional ondansetron doses were administered 4 and 8 hours later, or five additional metoclopramide doses were administered 2, 4, 7, 10, and 13 hours later. Cisplatin was administered over a period of 3 hours or less.

How long before chemo can you take Ondansetron?

In patients with severe hepatic impairment (Child-Pugh score of 10 or greater), a single maximal daily dose of 8 mg infused over 15 minutes beginning 30 minutes before the start of the emetogenic chemotherapy is recommended. There is no experience beyond first-day administration of ondansetron in these patients [see Use in Specific Populations (8.6)].

What drugs are used to treat serotonin syndrome?

Most reports have been associated with concomitant use of serotonergic drugs ( e.g., selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs ), monoamine oxidase inhibitors, mirtazapine, fentanyl, lithium, tramadol, and intravenous methylene blue). Some of the reported cases were fatal. Serotonin syndrome occurring with overdose of ZOFRAN alone has also been reported. The majority of reports of serotonin syndrome related to 5-HT 3 receptor antagonist use occurred in a post-anesthesia care unit or an infusion center.

Is Zofran more effective than placebo?

In a double-blind trial in 28 patients, Zofran Injection (three 0.15-mg/kg doses) was significantly more effective than placebo in preventing nausea and vomiting induced by cisplatin-based chemotherapy. Therapeutic response was as shown in Table 7.

Is Zofran contraindicated for hypersensitivity?

Zofran Injection is contraindicated for patients known to have hypersensitivity (e.g., ana phylaxis) to this product or any of its components. Anaphylactic reactions have been reported in patients taking ondansetron [see Adverse Reactions (6.2)].

How long before radiotherapy to give 8 mg?

For daily fractionated radiotherapy to the abdomen: 8 mg administered 1 to 2 hours before radiotherapy, with subsequent 8-mg doses every 8 hours after the first dose for each day radiotherapy is given. Postoperative. 16 mg administered 1 hour before induction of anesthesia.

How long before chemo do you give 16 mg?

16 mg administered 1 hour before induction of anesthesia. 12 to 17 years of age: 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 4 and 8 hours after the first dose. Then administer 8 mg three times a day for 1 to 2 days after completion of chemotherapy.

How long before chemo can you take cisplatin?

Cancer Chemotherapy. A single 24-mg dose administered 30 minutes before the start of single-day highly emetogenic chemotherapy, including cisplatin greater than or equal to 50 mg/m 2. Moderately Emetogenic. Cancer Chemotherapy. 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 8 hours after the first dose.

How long does it take to take 8 mg of chemo?

Cancer Chemotherapy. 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 8 hours after the first dose. Then administer 8 mg twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy. Radiotherapy.

Can you push Zofran through foil?

Do not attempt to push ZOFRAN ODT tablets through the foil backing. With dry hands, PEEL BACK the foil backing of 1 blister and GENTLY remove the tablet. IMMEDIATELY place the ZOFRAN ODT tablet on top of the tongue where it will dissolve in seconds, then swallow with saliva. Administration with liquid is not necessary.

How often is Zofran prescribed?

Zofran is often prescribed every 8 hours as needed for a maximum of 24 mg per day.

How long does it take for Zofran to work?

Zofran takes about 75 minutes to reach peak effect via the oral route and has a half-life of about 3-6 hours. Spreading out the dose by at least 8 hours is generally recommended. The orally disintegrating tablet may work faster and is administered by allowing the tablet to dissolve on the tongue. Zofran is also available in an IV formulation.

Does Zofran cause nausea?

Zofran is effective in treating many types of nausea and vomiting including: Zofran may cause headache, drowsiness, diarrhea, and constipation. It has been associated with QT prolongation and arrhythmias in those with heart conditions, electrolyte imbalances, and those taking other medications that prolong QT timing.

How to take Zofran ODT?

To take the orally disintegrating tablet (Zofran ODT): Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet. Use dry hands to remove the tablet and place it in your mouth.

Why is Zofran prescribed?

Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. Zofran may be used for purposes not listed in this medication guide.

What are the side effects of Zofran?

Common Zofran side effects may include: diarrhea or constipation; headache; drowsiness; or. tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Zofran side effects (more detail)

Can Zofran harm a baby?

Zofran is not expected to harm an unborn baby. Tell your doctor if you are pregnant. It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Ondansetron is not approved for use by anyone younger than 4 years old.

Is Zofran safe for you?

you are allergic to ondansetron or similar medicines (dolasetron, granisetron, palonosetron). To make sure Zofran is safe for you, tell your doctor if you have: an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); a blockage in your digestive tract (stomach or intestines).

Can you take Zofran if you are allergic to Ondansetron?

You should not use Zofran if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Zofran orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

What are the symptoms of Zofran?

Get emergency medical help if you have signs of an allergic reaction to Zofran: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe constipation, stomach pain, or bloating;

How long does it take to take Zofran?

The recommended adult intravenous dosage of ZOFRAN is 4 mg undiluted administered intravenously in not less than 30 seconds, preferably over 2 to 5 minutes, immediately before induction of anesthesia, or postoperatively if the patient did not receive prophylactic antiemetics and experiences nausea and/or vomiting.

Is ondansetron oral or oral?

Conclusions: Flavored intravenous ondansetron administered orally is a safe and an effective option and can be considered in the absence of the oral forms of the drug. Click to see full answer. Accordingly, can IV meds be given orally? IV medication is often used because of the control it provides over dosage.

How much cisplatin should I take for chemo?

Oral:#N#Highly Emetogenic Cancer Chemotherapy (HEC):#N#-Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC (including cisplatin doses of 50 mg/m2 or greater )#N#Moderately Emetogenic Cancer Chemotherapy (MEC):#N#-Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy#N#Parenteral:#N#-Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose.#N#-Maximum dose: 16 mg per dose#N#Comments:#N#-Multi-day, single-dose administration of 24 mg orally for HEC has not been studied.#N#-The injection formulation should be diluted prior to IV administration.#N#Uses:#N#-Prevention of nausea and vomiting associated with HEC or MEC#N#-Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy

How much IV nausea is recommended for a 12 year old?

Parenteral:#N#1 month to 12 years:#N#Less than 40 kg:#N#-Recommended dose: 0.1 mg/kg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)#N#40 kg and greater:#N#-Recommended dose: 4 mg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)#N#Use:#N#-Prevention of postoperative nausea and vomiting

How to take Ondansetron?

Take the ondansetron regular tablet with a full glass of water. To take the orally disintegrating tablet (Zofran ODT): Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.

How long does it take to take chemo?

Oral: 4 to 11 years: -Recommended dose: 4 mg orally 3 times a day, with the first dose administered 30 minutes before the start of chemotherapy, and subsequent doses 4 and 8 hours after the first dose; then 4 mg orally 3 times a day (every 8 hours) for 1 to 2 days after the completion of chemotherapy.

What are the side effects of Ondansetron?

Common ondansetron side effects may include: diarrhea or constipation; headache; drowsiness; or. tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What are the symptoms of Ondansetron?

Get emergency medical help if you have signs of an allergic reaction to ondansetron: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe constipation, stomach pain, or bloating;

Can Ondansetron cause heart problems?

Ondansetron can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS.

How long before chemo can you give 0.15 mg?

Parenteral: 6 months to 18 years: -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy, and subsequent doses given 4 and 8 hours after the first dose. -Maximum dose: 16 mg (per dose)

How much cisplatin should I take for chemo?

Oral:#N#Highly Emetogenic Cancer Chemotherapy (HEC):#N#-Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC (including cisplatin doses of 50 mg/m2 or greater )#N#Moderately Emetogenic Cancer Chemotherapy (MEC):#N#-Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy#N#Parenteral:#N#-Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose.#N#-Maximum dose: 16 mg per dose#N#Comments:#N#-Multi-day, single-dose administration of 24 mg orally for HEC has not been studied.#N#-The injection formulation should be diluted prior to IV administration.#N#Uses:#N#-Prevention of nausea and vomiting associated with HEC or MEC#N#-Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy

How much IV nausea is recommended for a 12 year old?

Parenteral:#N#1 month to 12 years:#N#Less than 40 kg:#N#-Recommended dose: 0.1 mg/kg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)#N#40 kg and greater:#N#-Recommended dose: 4 mg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)#N#Use:#N#-Prevention of postoperative nausea and vomiting

How long before chemo do you give emetogenic chemotherapy?

Parenteral: -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose. -Maximum dose: 16 mg per dose. Comments:

How long does it take to take chemo?

4 to 11 years: -Recommended dose: 4 mg orally 3 times a day, with the first dose administered 30 minutes before the start of chemotherapy, and subsequent doses 4 and 8 hours after the first dose; then 4 mg orally 3 times a day (every 8 hours) for 1 to 2 days after the completion of chemotherapy. 12 years and older: ...

Indications and Usage For Zofran Injection

Zofran Injection Dosage and Administration

Dosage Forms and Strengths

Contraindications

Warnings and Precautions

Adverse Reactions

Drug Interactions

Use in Specific Populations

Drug Abuse and Dependence

Overdosage