fluconazole contraindications

Precautions

More serious (but less common) side effects include:

• QT prolongation
• Anaphylactic reactions
• Cholestasis
• Liver failure/liver issues
• Jaundice

What do I do if I take too much fluconazole?

There is no interaction between alcohol and fluconazole (Diflucan), but drinking alcohol might raise your risk of or worsen some side effects, such as nausea, stomach pain, and diarrhea, if you drink alcohol. It is possible to develop liver damage if you drink a lot of alcohol while taking fluconazole (Diflucan).

Should I avoid alcohol while taking fluconazole?

Yes: That should be fine. Avoid carbs: Assuming you are taking Diflucan (fluconazole) for a yeast infection, it would be best to avoid foods and drinks that turn to sugar in your body, incl... Read More Can i drink alcohol while taking difucan? It is always prudent: Not to drink while you are on medication.

Is it safe to drink on fluconazole?

It’s also important to note that Diflucan has a long half-life, which means that you should make sure it’s completely eliminated from your system before drinking. Speak with your physician for more specific recommendations regarding alcohol and Diflucan.

How long after taking Diflucan can you drink alcohol again?

What drugs can you not take with fluconazole?

Drugs that should not be used with fluconazoleTerfenadine. When used with fluconazole at doses of 400 mg or higher, this drug can cause a life-threatening heart rhythm condition called torsades de pointes.Pimozide, clarithromycin, erythromycin, ranolazine, lomitapide, donepezil, voriconazole, and quinidine.

Does fluconazole interact with anything?

Products that may interact with this drug include: clopidogrel. Many drugs besides fluconazole may affect the heart rhythm (QT prolongation), including pimozide, quinidine, macrolide antibiotics (such as erythromycin), among others.

What are the adverse effects of fluconazole?

Side EffectsChest tightness.clay-colored stools.difficulty with swallowing.fast heartbeat.hives, itching, or skin rash.large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals.light-colored stools.stomach pain, continuing.More items...•

Why is fluconazole contraindicated in pregnancy?

“Specifically, use of high-dose fluconazole during pregnancy has been linked to a pattern of major congenital malformations resembling the Antley-Bixler syndrome, a genetic disorder associated with reduced activity of [the fungal cytochrome P451 enzyme] owing to genetic mutations.

Can you take vitamins with fluconazole?

No interactions were found between fluconazole and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can I take fluconazole with omeprazole?

Fluconazole can increase the blood levels of omeprazole. This may increase side effects such as diarrhea, abdominal pain, nausea, vomiting, and flatulence.

How safe is fluconazole?

A prescription-event monitoring (PEM) study has confirmed that fluconazole, a bis-triazole oral antifungal drug, is a safe and effective treatment for vaginal candidiasis.

Can fluconazole cause heart palpitations?

Fluconazole may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

What happens if you take fluconazole without yeast infection?

If you don't really have a yeast infection, antifungals won't help you get better. They can actually prolong the real problem, because while you'll think you're treating the issue, the real cause will continue to develop. There are several reasons you might have symptoms that are like a yeast infection.

Can a pregnant person take fluconazole?

Fluconazole treats the unpleasant symptoms associated with vaginal thrush, which is a common pregnancy problem. While fluconazole is generally not recommended in pregnancy, it is sometimes prescribed to treat severe thrush that has not responded to other medicines.

Is fluconazole safe during early pregnancy?

In summary, it is unlikely that the use of a single low dose of oral fluconazole during early pregnancy would greatly increase the chance of birth defects. However, the use of high dose fluconazole for many weeks might be associated with an increase in the chance of birth defects in the exposed baby.

Can you take fluconazole when pregnant?

Treating thrush during pregnancy Normally, thrush can also be treated with antifungal tablets called fluconazole. But, if you're pregnant, trying to get pregnant or breastfeeding, you should not take anti-thrush tablets.

Before Taking This Medicine

You should not use fluconazole if you are allergic to it.Some medicines can cause unwanted or dangerous effects when used with fluconazole. Your do...

How Should I Take Fluconazole?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.Your do...

What Happens If I Miss A Dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What Happens If I Overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include confusion or unusual thoughts or beh...

What Should I Avoid While Taking Fluconazole?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.Avoid driving or hazardous activity until you know how thi...

What Other Drugs Will Affect Fluconazole?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may in...

How many patients were treated with fluconazole?

Sixteen percent of over 4000 patients treated with Fluconazole in clinical trials of 7 days or more experienced adverse events. Treatment was discontinued in 1.5% of patients due to adverse clinical events and in 1.3% of patients due to laboratory test abnormalities.

What is fluconazole used for?

Fluconazole is a highly selective inhibitor of fungal cytochrome P450 dependent enzyme lanosterol 14-α-demethylase. This enzyme functions to convert lanosterol to ergosterol. The subsequent loss of normal sterols correlates with the accumulation of 14-α-methyl sterols in fungi and may be responsible for the fungistatic activity of Fluconazole. Mammalian cell demethylation is much less sensitive to Fluconazole inhibition.

How is fluconazole cleared?

In normal volunteers, Fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug. About 11% of the dose is excreted in the urine as metabolites. The pharmacokinetics of Fluconazole are markedly affected by reduction in renal function.

How long does fluconazole stay in your system?

Following either single- or multiple-oral doses for up to 14 days, Fluconazole penetrates into all body fluids studied (see table below). In normal volunteers, saliva concentrations of Fluconazole were equal to or slightly greater than plasma concentrations regardless of dose, route, or duration of dosing.

How much azithromycin is in a crossover study?

Azithromycin: An open-label, randomized, three-way crossover study in 18 healthy subjects assessed the effect of a single 1200 mg oral dose of azithromycin on the pharmacokinetics of a single 800 mg oral dose of Fluconazole as well as the effects of Fluconazole on the pharmacokinetics of azithromycin.

Does fluconazole increase terfenadine levels?

Another study at a 400 mg and 800 mg daily dose of Flucon azole demonstrated that Fluconazole taken in doses of 400 mg/day or greater significantly increases plasma levels of terfenadine when taken concomitantly. The combined use of Fluconazole at doses of 400 mg or greater with terfenadine is contraindicated.

Is fluconazole a CYP3A4 inhibitor?

(See CONTRAINDICATIONS .) Fluconazole is a moderate CYP2C9 and CYP3A4 inhibitor. Flucona zole is also a strong inhibitor of CYP2C19. Patients treated with Fluconazole, who are also concomitantly treated with drugs with a narrow therapeutic window metabolized through CYP2C9 and CYP3A4, should be monitored for adverse reactions associated with the concomitantly administered drugs. In addition to the observed/documented interactions mentioned below, there is a risk of increased plasma concentration of other compounds metabolized by CYP2C9, CYP2C19, and CYP3A4 co-administered with Fluconazole. Therefore, caution should be exercised when using these combinations and the patients should be carefully monitored. The enzyme inhibiting effect of Fluconazole persists 4 to 5 days after discontinuation of Fluconazole treatment due to the long half-life of Fluconazole. Clinically or potentially significant drug interactions between Fluconazole and the following agents/classes have been observed and are described in greater detail below:

How to take fluconazole?

Fluconazole oral is taken by mouth. Fluconazole injection is given as an infusion into a vein. You may take fluconazole oral with or without food. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

What is fluconazole used for?

Fluconazole is an antifungal medicine that is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, bladder, genital area, and the blood. Fluconazole is also used to prevent fungal infection in people who have a weak immune system caused by cancer treatment, ...

Why is fluconazole used for meningitis?

Fluconazole is also used to prevent fungal infection in people who have a weak immune system caused by cancer treatment, bone marrow transplant, or diseases such as AIDS. Fluconazole is also used to treat a certain type of meningitis in people with HIV or AIDS.

Can fluconazole harm a baby?

Talk to your doctor before using this form of fluconazole if you have a problem digesting sugars or milk. Fluconazole may harm an unborn baby. Use effective birth control to prevent pregnancy while taking fluconazole and for at least 1 week after your last dose.

Can you take fluconazole and other medications at the same time?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Fluconazole can cause a serious heart problem.

Does fluconazole cause hives?

Fluconazole side effects. Get emergency medical help if you have signs of an allergic reaction ( hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Can you take fluconazole if it looks cloudy?

Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine. Use fluconazole for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication.

How to avoid fluconazole?

Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine (fluconazole tablets) affects you. Do not use longer than you have been told. A second infection may happen. Have blood work checked as you have been told by the doctor. Talk with the doctor.

What is fluconazole used for?

Uses of Fluconazole Tablets: It is used to treat fungal infections. It is used to prevent fungal infections. This medicine is used to treat vaginal yeast infections. It may be given to you for other reasons. Talk with the doctor.

Can you take fluconazole with all your medications?

You must check to make sure that it is safe for you to take this medicine (fluconazole tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Can fluconazole cause a fast heartbeat?

Sometimes, this has led to another type of unsafe abnormal heartbeat (torsades de pointes). Call your doctor right away if you have a fast or abnormal heartbeat, or if you pass out.

Can you share fluconazole with others?

Do not share your drugs with others and do not take anyone else's drugs. Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine (fluconazole tablets), please talk with your doctor, nurse, pharmacist, or other health care provider.

Can fluconazole harm a baby?

This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking this medicine (fluconazole tablets), call your doctor right away. Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Can you take fluconazole if you are 65?

If you have questions, talk with the doctor. If you are 65 or older, use this medicine (fluconazole tablets) with care. You could have more side effects.

Is Candida krusei resistant to fluconazole?

Candida krusei is inherently resistant. Convenience and efficacy of single dose oral tablet of fluconazole regimen for the treatment of vaginal yeast infections should be weighed against acceptability of higher incidence of drug related adverse events with fluconazole (26%) versus intravaginal agents (16%)

Can fluconazole be used during pregnancy?

Use in pregnancy should be avoided except in patients with severe or potentially life-threatening fungal infections in whom fluconazole may be used if the anticipated benefit outweighs the possible risk to the fetus

How many drugs interact with fluconazole?

Fluconazole has serious interactions with at least 84 different drugs. Fluconazole has moderate interactions with at least 186 different drugs. Fluconazole has mild interactions with at least 96 different drugs. This information does not contain all possible interactions or adverse effects.

What is fluconazole used for?

Fluconazole is used to treat vaginal yeast infections. It works by stopping the growth of common types of vaginal yeast ( fungus ). This medication belongs to a class of drugs called azole antifungals. Fluconazole is available under the following different brand names: Diflucan. Dosages of Fluconazole: Adult and Pediatric Dosage Forms and Strengths.

Is Candida krusei resistant to fluconazole?

Candida krusei is inherently resistant. Convenience and efficacy of single dose oral tablet of fluconazole regimen for the treatment of vaginal yeast infections should be weighed against acceptability of higher incidence of drug related adverse events with fluconazole (26%) versus intravaginal agents (16%)

How long to treat fluconazole?

12 mg/kg/dose PO once daily for fluconazole-susceptible isolates. In general, doses exceeding 600 mg are not recommended. Treat for at least 4 to 6 weeks with final duration depending on resolution of lesions.

How long after a valve replacement can you take fluconazole?

12 mg/kg/dose IV once daily as step-down therapy after lipid amphotericin B or echinocandin therapy in stable patients with negative blood cultures. In general, doses exceeding 600 mg are not recommended. For endocarditis, treat for at least 6 weeks after valve replacement. For infected cardiac hardware, treat for at least 4 to 6 weeks after hardware removal. When valve replacement or hardware removal is not possible, chronic suppressive therapy with fluconazole is recommended after initial treatment. Treat suppurative thrombophlebitis for at least 2 weeks after candidemia (if present) has cleared.

How long does fluconazole stay in your system?

400 mg (6 mg/kg) IV once daily for at least 8 weeks after initial at least 2-week course of amphotericin B deoxycholate plus flucytosine is recommended by guidelines. Cryptococcosis guidelines suggest alternatives for primary therapy including fluconazole 800 mg IV once daily plus amphotericin B deoxycholate for 2 weeks, followed by fluconazole 800 mg IV once daily for at least 8 weeks; fluconazole 1,200 mg IV once daily plus flucytosine for 6 weeks; or fluconazole 1,200 to 2,000 mg IV once daily for 10 to 12 weeks. Opportunistic infections guidelines in HIV-infected patients suggest alternatives for primary therapy including fluconazole 800 mg IV once daily plus amphotericin B deoxycholate or liposomal amphotericin B for at least 2 weeks; fluconazole 400 or 800 mg IV once daily plus flucytosine for 2 weeks; or fluconazole 1,200 mg IV once daily for 2 weeks with all initial 2-week courses followed by fluconazole 400 mg IV once daily for at least 8 weeks. Follow with fluconazole 200 mg IV once daily for at least 12 months. Suppressive therapy discontinuation may be considered in patients receiving HAART therapy with a CD4 count more than 100 cells/mm3 and an undetectable or very low HIV RNA concentration for at least 3 months (after at least 12 months of antifungal therapy). The FDA-approved dosage is 12 mg/kg/dose IV on day 1, followed by 6 to 12 mg/kg/dose IV once daily for 10 to 12 weeks after cerebrospinal fluid culture becomes negative. Follow with 6 mg/kg/dose IV once daily for suppressive therapy.

Is fluconazole safe for children?

Fluconazole is approved for all pediatric populations. The safety of fluconazole has been studied in children ages 1 day to 17 years; however, experience with fluconazole in neonates is limited to pharmacokinetic studies in premature newborns. Several studies have shown fluconazole to be effective in treating oropharyngeal candidiasis in children 6 months to 13 years. Fluconazole has also been shown effective in treating serious systemic fungal infections and for suppression of cryptococcal meningitis; there is no information regarding the efficacy of fluconazole for primary treatment of cryptococcal meningitis in children. Pharmacokinetic studies in children have established dose proportionality between children and adults.

Can you take fluconazole while breast feeding?

Use caution when fluconazole is administered to a breast-feed ing woman. [28674] Previous American Academy of Pediatrics (AAP) recommendations considered fluconazole as usually compatible with breast-feeding. [27500] Fluconazole is distributed in human breast milk at concentrations similar to those in the plasma. A case report found breast milk to plasma ratios of 0.46, 0.85, 0.85, and 0.83 at 2, 5, 24, and 48 hours after a single 150 mg dose of fluconazole. [46093] Experts have estimated, based on limited data of concentrations in breast milk, that an exclusively breast-fed infant whose mother was receiving fluconazole 200 mg daily would receive a maximum dose of 0.6 mg/kg/day. This is equivalent to 60% of the recommended dose for thrush in newborns younger than 2 weeks of age and 20% of the recommended dose for older newborns and infants. [46094] Another study determined the daily infant fluconazole dose from breast milk (assuming mean milk consumption of 150 mL/kg/day) based on the mean peak milk concentration (2.61 mcg/mL [range: 1.57 to 3.65 mcg/mL] at 5.2 hours post-dose) to be 0.39 mg/kg/day, which is approximately 13% of the recommended pediatric dose for oropharyngeal candidiasis. [28674] Fluconazole has been used successfully to treat mastitis due to yeast resistant to other therapies in breast-feeding mothers. [46095] [46096]

Is fluconazole hepatotoxic?

Fluconazole can be hepatotoxic and should be used with caution in patients with pre existing hepatic disease . The related azole, ketoconazole, also has been associated with hepatotoxicity. Liver-function tests should be monitored. If signs and symptoms of hepatotoxicity develop, fluconazole therapy should be stopped.

Can fluconazole cause QT prolongation?

During post-marketing surveillance, rare cases of QT prolongation and torsade de pointes have been reported with fluconazole use. These reports have included seriously ill patients with multiple confounding risk factors that may have been contributory, such as structural cardiac disease, electrolyte imbalance, and concomitant medications that could be associated with proarrhythmic conditions. Fluconazole is not likely to cause QT prolongation or torsade de pointes when administered at usual therapeutic dosages. Use fluconazole with caution in patients with conditions that may increase the risk of QT prolongation including congenital long QT syndrome, bradycardia, AV block, heart failure, stress-related cardiomyopathy, myocardial infarction, stroke, hypomagnesemia, hypokalemia, hypocalcemia, or in patients receiving medications known to prolong the QT interval or cause electrolyte imbalances. Females, people 65 years and older, patients with sleep deprivation, pheochromocytoma, sickle cell disease, hypothyroidism, hyperparathyroidism, hypothermia, systemic inflammation (e.g., human immunodeficiency virus (HIV) infection, fever, and some autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus (SLE), and celiac disease) and patients undergoing apheresis procedures (e.g., plasmapheresis [plasma exchange], cytapheresis) may also be at increased risk for QT prolongation.

Conditions

This survey is being conducted by the WebMD marketing sciences department.

Are you currently using fluconazole-ibuprofen-itraconazole-terbinafine topical?

This survey is being conducted by the WebMD marketing sciences department.

Availability

Chemistry

Description

Pharmacology

Contraindications

Toxicity

Side effects

Epidemiology

Example

• The Cmax and AUC data from a food-effect study involving administration of Fluconazole tablets to healthy volunteers under fasting conditions and with a high-fat meal indicated that exposure to the drug is not affected by food. Therefore, Fluconazole may be taken without regard to meals. (See DOSAGE AND ADMINISTRATION)

See more on drugs.com

Administration

Interactions

Safety

Results

Effects

Mechanism of action

Research

Mechanism