Can Claritin and Neupogen help with bone pain?
During this last session of chemo, my onco nurse told me to take a Claritin each morning when I get Neupogen to help with bone pain. My pain this time seemed to be less. Have you guys used this combination to minimize bone pain?
Why would Claritin be recommended for chronic pain?
It was probably recommended to you because one of the other meds you were taking was an NSAID (Non-steroidal anti-inflamatory) which can cause gastric upset or even bleeding. The third was likely the antihistamine. Yep, add me to the anecdotal pile of those using Claritin off label for chronic pain. Love the stuff.
Can Claritin be taken with Neulasta?
1 loratadine 10mg tablet daily, in the morning for 5 days, starting on the day Neulasta is given. Bone pain is a very common side effect of Neulasta. Clinical studies on Claritin to reduce bone pain from Neulasta show minimal reduction in pain.
Can you take Claritin after a blood cell stimulator?
If you are taking a Blood Cell Stimulator: Claritin®(loratadine) 10mg, take 1 the day prior to injection, take 1 the day of the injection, and 1 a day for 4 days after the injection (6 days total). Take only if your doctor says it is okay and only as directed.
Does Claritin help with bone pain from Neulasta?
Although Claritin (loratadine) has a minimal effect on pain it is well tolerated, inexpensive and easily administered so may be considered to help reduce bone pain in Neulasta patients.
Why does Claritin help with Neulasta?
Claritin is an antihistamine medication. It works by blocking the action of histamine. By doing so, Claritin may help reduce bone pain in people taking Neulasta, but more research is needed. If you're taking Neulasta and having bone pain, talk with your doctor.
What helps Neulasta bone pain?
If you develop bone pain while using Neulasta, contact your doctor. They may suggest you take a pain reliever, such as ibuprofen (Advil, Motrin) or naproxen (Aleve). Or they may recommend you stop using Neulasta.
How long does bone pain last with Neupogen?
You may be wondering how long this bone pain lasts. For most people, it starts within 2 days of receiving the drug. The duration of bone pain from Neulasta is usually 2 to 4 days.
Can Claritin be used for bone pain?
We sometimes use loratadine (Claritin) to treat bone pain in patients receiving white blood cell growth factors. How does this work? White blood cell growth factors are used in the prevention and treatment of febrile neutropenia in patients receiving myelosuppressive chemotherapy.
Can antihistamines reduce inflammation?
Antihistamines have recently been shown to have anti-inflammatory properties that are more extensive than simply the blocking of histamine receptors. For example, new evidence suggests that the suppression of cell adhesion molecule expression occurs with these drugs.
What helps Neupogen bone pain?
Your doctor may prescribe a non-steroidal anti-inflammatory drug (NSAID) such as ibuprofen or naproxen to treat bone pain caused by Neupogen. Neupogen helps the body make more white blood cells by stimulating the immune system, which also creates histamines.
Does Claritin help with chemo side effects?
Second-generation H1-antihistamines include cetirizine (Zyrtec), loratadine (Claritin), and, more recently, fexofenadine (Allegra). These drugs, which block histamines released by immune cells, are widely used in cancer patients not only to relieve allergy symptoms, but also to prevent nausea and vomiting.
Does Claritin help with swelling?
OTC antihistamines like Zyrtec and Claritin can be used to treat allergic rhinitis (swelling of the nasal lining), allergic conjunctivitis (inflammation around the eyes), and hives (urticaria).
How long do Neupogen side effects last?
There is little information available from reliable sources about how long Neulasta side effects last. Neulasta is a long lasting medicine, with peak levels achieved 24 hours after injection, levels drop considerably over the first 7 days and after 14 days there is only a small amount remaining in the body.
How does loratadine help with bone pain?
Brief Summary: G-CSF causes a release of histamine that may be a cause of chronic bone pain. Loratadine targets histamine, and so may be effective in reducing bone pain. The researchers plan to prospectively assess the effectiveness of loratadine for chronic bone pain in patients with chronic G-CSF use.
Does Zyrtec help bone pain?
Some antihistamines also have anti-inflammatory effects. Antihistamines have been suggested as a second-line treatment for bone pain associated with colony-stimulating factor use in patients who do not benefit from the acetaminophen of NSAIDs.
Why is Claritin used with Pegfilgrastim?
The reason why Claritin (loratadine) is taken with Neulasta (pegfilgrastim) is to reduce bone pain, which is a very common side effect of Neulasta. When patients are undergoing chemotherapy it often causes a decrease in neutrophils levels (which is a type of white blood cell that fights infection) and this increases the risk of infections.
What antihistamines are used for Neulasta?
In this small study they used both famotidine and loratadine which they concluded was an inexpensive, safe and effective way to reduce bone pain.
How long does loratadine last?
The loratadine dose to prevent bone pain from Neulasta in the NOLAN clinical trial was. 1 loratadine 10mg tablet daily, in the morning for 5 days, starting on the day Neulasta is given.
Does Neulasta cause pain?
It is thought that some of the bone pain that is caused by Neulasta is due to the effect Neulasta has on histamine, which induces inflammation and swelling in the bone marrow and results in pain. Claritin is an antihistamine that blocks histamine, so decreases the amount of inflammation and swelling in the bone marrow and therefore reduces the pain.
Does Claritin help with bone pain?
Although Claritin (loratadine) has a minimal effect on pain it is well tolerated, inexpensive and easily administered so may be considered to help reduce bone pain in Neulasta patients.
What is the best treatment for bone pain caused by white blood cells?
Treatment options for bone pain caused by white blood cell growth factors include antihistamines, nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and opioids for severe pain. There is relatively limited clinical data studying the use of loratadine and other antihistamines for bone pain in this setting.
How long does loratadine last after chemo?
In the report on the use of loratadine, a patient with severe bone pain thought to be due to pegfilgrastim took loratadine 10 mg daily starting the day prior to chemotherapy through 5 days following chemotherapy.
What is loratadine used for?
We sometimes use loratadine (Claritin) to treat bone pain in patients receiving white blood cell growth factors. How does this work? White blood cell growth factors are used in the prevention and treatment of febrile neutropenia in patients receiving myelosuppressive chemotherapy. They may also be used for mobilization of stem cells prior ...
What causes bone pain from white blood cells?
Bone pain from white blood cell growth factors involves multiple factors, including inflammation and histamine release. Although the exact mechanism of this pain is not well understood, one potential mechanism is that histamine may cause bone marrow edema and result in pain. Treatment options for bone pain caused by white blood cell growth factors ...
Is loratadine good for bone pain?
Loratadine may be preferred over older antihistamines such as hydroxyzine, as it is associated with less sedation and fewer anticholinergic side effects (eg, dry mouth), although these may still occur in some patients. Patients receiving loratadine for bone pain due to white blood cell growth factors should be educated about potential adverse ...
Does lotaradine help with allergies?
I take lortaradine on a daily basis and have mild chronic pain issues. The lotaradine pills do nothing for the pain. They help out with my allergies like nothing else, but doesn’t do a thing for even the mildest pain.
Is NSAID a placebo?
If it’s helping your inflamation/pain/hives, it’s a placebo effect. It was probably recommended to you because one of the other meds you were taking was an NSAID (Non-steroidal anti-inflamatory) which can cause gastric upset or even bleeding. The third was likely the antihistamine. WhyNot August 25, 2013, 9:16am #11.
How long to take Claritin 10mg?
Claritin®( loratadine) 10mg, take 1 the day prior to injection, take 1 the day of the injection, and 1 a day for 4 days after the injection (6 days total). Take only if your doctor says it is okay and only as directed.
Can chemotherapy cause nail damage?
Chemotherapy may cause changes to your fingernails and toenails. Some changes may be cosmetic. Other changes may lead to more serious problems such as infection. Fingernails are affected more than toenails. Most nail changes are temporary. Nails will usually get back to normal in about 6 months (but can take longer) after finishing treatment. Some of the most common nail changes during chemotherapy are:
Does chemotherapy cause peripheral neuropathy?
Chemotherapy Induced Peripheral Neuropathy is any injury, inflammation, or a loss of function of peripheral nerves (nerves that send messages to and from your brain) caused by chemotherapy. It affects the following nerves: motor nerves (control muscle) and sensory or autonomic nerves (control heart rate, body temperature, and breathing). Peripheral neuropathy can start with mild symptoms and may gradually get worse as treatment continues. It affects 30 to 40 per cent of patients undergoing chemotherapy.