What is the Max dose of Zofran?
Max: 16 mg/dose. The American Society of Clinical Oncology (ASCO) recommends 0.15 mg/kg/dose (Max: 8 mg) twice daily during chemotherapy and for 2 days after completion, or give 1 to 2 hours before each fraction of radiation and for 1 day after completion for highly emetogenic therapy.
How much Zofran is too much?
The total daily dose should not be more than 8 mg. Zofran tablets should start to work within one or two hours of taking a dose. - otherwise, do not take more Zofran tablets than the label says. - do not take a double dose to make up for a forgotten dose.
Is Zofran actually dangerous?
Zofran (ondansetron), a prescription medication for nausea, can be dangerous for some people. That includes anyone who is allergic to the active ingredient, ondansetron. It may affect your heart rate, and can be dangerous for people with a family history of “Long QT” syndrome, a heart condition. It may also pose risks for people with liver disease and a genetic condition called PKU.
What does Zofran do to a normal person?
Zofran ODT (ondansetron) is an antiemetic drug that helps prevent nausea and vomiting. This prescription medication dissolves on the top of your tongue and works by preventing a chemical called serotonin from reaching certain cells in the brain. Zofran ODT is available as an orally disintegrating tablet.
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Before Taking This Medicine
You should not use Zofran if: 1. you are also using apomorphine (Apokyn); or 2. you are allergic to ondansetron or similar medicines (dolasetron, g...
How Should I Take Zofran?
Take Zofran exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include sudden loss of vision, severe constip...
What Should I Avoid While Taking Zofran?
Zofran may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
What Other Drugs Will Affect Zofran?
Zofran can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart r...
How to take Zofran ODT?
To take the orally disintegrating tablet (Zofran ODT): Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet. Use dry hands to remove the tablet and place it in your mouth.
What are the side effects of Zofran?
Common Zofran side effects may include: diarrhea or constipation; headache; drowsiness; or. tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Zofran side effects (more detail)
Why is Zofran prescribed?
Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. Zofran may be used for purposes not listed in this medication guide.
What is Ondansetron narcotic?
a narcotic (opioid) medication; or. medicine to prevent nausea and vomiting. This list is not complete and many other drugs can interact with ondansetron. This includes prescription and over-the-counter medicines, vitamins, and herbal products.
Can Zofran harm a baby?
Zofran is not expected to harm an unborn baby. Tell your doctor if you are pregnant. It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Ondansetron is not approved for use by anyone younger than 4 years old.
Is Zofran safe for you?
you are allergic to ondansetron or similar medicines (dolasetron, granisetron, palonosetron). To make sure Zofran is safe for you, tell your doctor if you have: an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); a blockage in your digestive tract (stomach or intestines).
Can you take Zofran if you are allergic to Ondansetron?
You should not use Zofran if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Zofran orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
What are the indications for cisplatin50 mg/m2?
INDICATIONS & USAGE. 1. Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including cisplatin50 mg/m2. 2. Prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy. 3. Prevention of nausea and vomiting associated with radiotherapy in patients ...
Can you push Zofran through foil?
Do not attempt to push ZOFRAN ODT Tablets through the foil backing. With dry hands, PEEL BACK the foil backing of 1 blister and GENTLY remove the tablet. IMMEDIATELY place the ZOFRAN ODT Tablet on top of the tongue where it will dissolve in seconds, then swallow with saliva. Administration with liquid is not necessary.
How long after radiotherapy should I take 8 mg of a sulfate?
For single high-dose fraction radiotherapy to the abdomen: 8 mg administered 1 to 2 hours before radiotherapy, with subsequent 8-mg doses every 8 hours after the first dose for 1 to 2 days after completion of radiotherapy.
How long before radiotherapy to give 8 mg?
For daily fractionated radiotherapy to the abdomen: 8 mg administered 1 to 2 hours before radiotherapy, with subsequent 8-mg doses every 8 hours after the first dose for each day radiotherapy is given. Postoperative. 16 mg administered 1 hour before induction of anesthesia.
How long does it take to take 8 mg of chemo?
Cancer Chemotherapy. 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 8 hours after the first dose. Then administer 8 mg twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy. Radiotherapy.
How long before chemo do you give 16 mg?
16 mg administered 1 hour before induction of anesthesia. 12 to 17 years of age: 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 8 hours after the first dose. Then administer 8 mg twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy.
How long before chemo can you take cisplatin?
Cancer Chemotherapy. A single 24-mg dose administered 30 minutes before the start of single-day highly emetogenic chemotherapy, including cisplatin greater than or equal to 50 mg/m 2. Moderately Emetogenic. Cancer Chemotherapy. 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 8 hours after the first dose.
What is 4 mg of Zofran?
4 mg (ondansetron hydrochloride dihydrate equivalent to 4 mg of ondansetron), are white, oval, film-coated tablets engraved with “Zofran” on one side and “4” on the other in bottles of 30 tablets (NDC 0078-0675-15).
What is the Zofran tablet?
ZOFRAN tablets are oval, film-coated tablets engraved with “Zofran” on one side and are available in the following strengths: 4 mg - white tablet with “4” engraved on the other side. 8 mg - yellow tablet with “8” engraved on the other side.
What is the active ingredient in Zofran?
The active ingredient in ZOFRAN tablets and ZOFRAN oral solution is ondansetron hydrochloride as the dihydrate, the racemic form of ondansetron and a selective blocking agent of the serotonin 5-HT 3 receptor type.
How long does it take to take 8 mg of chemo?
Dosage Regimen. Moderately Emetogenic Cancer Chemotherapy. 12 to 17 years of age: 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 8 hours after the first dose. Then administer 8 mg twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy.
What are the adverse reactions to Zofran?
The most common adverse reactions (greater than or equal to 2%) reported in patients receiving ZOFRAN and concurrent radiotherapy were similar to those reported in patients receiving ZOFRAN and concurrent chemotherapy and were headache, constipation, and diarrhea.
Does Ondansetron inhibit P450?
Ondansetron does not itself appear to induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liver [see CLINICAL PHARMACOLOGY ]. Because ondansetron is metabolized by hepatic cytochrome P450 drug-metabolizing enzymes (CYP3A4, CYP2D6, CYP1A2), inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron. In patients treated with potent inducers of CYP3A4 (i.e., phenytoin, carbamazepine, and rifampin), the clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreased. However, on the basis of available data, no dosage adjustment for ZOFRAN is recommended for patients on these drugs [see CLINICAL PHARMACOLOGY ].
How much hepatic pugh is recommended for a 10 year old?
In patients with severe hepatic impairment (Child-Pugh score of 10 or greater), do not exceed a total daily dose of 8 mg [see Use In Specific Populations, CLINICAL PHARMACOLOGY ].
What is the strength of Zofran?
Zofran tablets are oval, film-coated tablets engraved with “Zofran” on one side and are available in the following strengths: 4 mg – white tablet with “4” engraved on the other side. 8 mg – yellow tablet with “8” engraved on the other side.
What are the adverse reactions to Zofran?
The most common adverse reactions (greater than or equal to 2%) reported in patients receiving Zofran and concurrent radiotherapy were similar to those reported in patients receiving Zofran and concurrent chemotherapy and were headache, constipation, and diarrhea.
How much ondansetron should pregnant rats take?
At doses of 15 mg/kg/day in rats and 30 mg/kg/day in rabbits, the maternal exposure margin was approximately 6 and 24 times the maximum recommended human oral dose of 24 mg/day, respectively, based on body surface area.
How long after chemo do you give 4 mg?
Then administer 4 mg three times a day for 1 to 2 days after completion of chemotherapy.
Is Zofran a placebo?
In two randomized, double-blind, monotherapy trials, a single 24-mg oral dose of Zofran was superior to a relevant historical placebo control in the pre vention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including cisplatin greater than or equal to 50 mg/m 2. Steroid administration was excluded from these clinical trials. More than 90% of patients receiving a cisplatin dose greater than or equal to 50 mg/m 2 in the historical placebo comparator experienced vomiting in the absence of antiemetic therapy.
Does Ondansetron affect gastric motility?
In healthy subjects, single intravenous doses of 0.15 mg/kg of ondansetron had no effect on esophageal motility, gastric motility, lower esophageal sphincter pressure, or small intestinal transit time. Multiday administration of ondansetron has been shown to slow colonic transit in healthy subjects. Ondansetron has no effect on plasma prolactin concentrations.
Is Ondansetron a dopamine receptor antagonist?
Ondansetron is a selective 5‑HT 3 receptor antagonist. While its mechanism of action has not been fully characterized, ondansetron is not a dopamine‑receptor antagonist. Serotonin receptors of the 5‑HT 3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. It is not certain whether ondansetron’s antiemetic action is mediated centrally, peripherally, or in both sites. However, cytotoxic chemotherapy appears to be associated with release of serotonin from the enterochromaffin cells of the small intestine. In humans, urinary 5‑hydroxyindoleacetic acid (5‑HIAA) excretion increases after cisplatin administration in parallel with the onset of emesis. The released serotonin may stimulate the vagal afferents through the 5‑HT 3 receptors and initiate the vomiting reflex.
What Is Zofran ODT?
Zofran ODT (ondansetron) is an antiemetic drug that helps prevent nausea and vomiting. This prescription medication dissolves on the top of your tongue and works by preventing a chemical called serotonin from reaching certain cells in the brain.
What Is Zofran ODT Used For?
The Food and Drug Administration (FDA) has approved Zofran ODT to prevent: 1
What Are the Side Effects of Zofran ODT?
This is not a complete list of side effects, and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
Dosage: How Much Zofran ODT Should I Take?
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
Overdose: What Happens If I Take Too Much Zofran ODT?
Cases of accidental Zofran overdose in children have been reported. Their symptoms were consistent with serotonin syndrome.
Precautions
Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.
What Other Medications Interact With Zofran ODT?
When taken with Zofran ODT, several medications may increase your risk of developing serotonin syndrome. Along with Zofran ODT, if you are taking a medicine that increases serotonin levels in the body, your doctor may need to choose a different treatment or monitor you more closely.
How much cisplatin should I take for chemo?
Oral:#N#Highly Emetogenic Cancer Chemotherapy (HEC):#N#-Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC (including cisplatin doses of 50 mg/m2 or greater )#N#Moderately Emetogenic Cancer Chemotherapy (MEC):#N#-Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy#N#Parenteral:#N#-Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose.#N#-Maximum dose: 16 mg per dose#N#Comments:#N#-Multi-day, single-dose administration of 24 mg orally for HEC has not been studied.#N#-The injection formulation should be diluted prior to IV administration.#N#Uses:#N#-Prevention of nausea and vomiting associated with HEC or MEC#N#-Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy
How long before chemo can you give 0.15 mg?
Parenteral: 6 months to 18 years: -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy, and subsequent doses given 4 and 8 hours after the first dose. -Maximum dose: 16 mg (per dose)
How much IV nausea is recommended for a 12 year old?
Parenteral:#N#1 month to 12 years:#N#Less than 40 kg:#N#-Recommended dose: 0.1 mg/kg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)#N#40 kg and greater:#N#-Recommended dose: 4 mg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)#N#Use:#N#-Prevention of postoperative nausea and vomiting
How long does it take to take chemo?
4 to 11 years: -Recommended dose: 4 mg orally 3 times a day, with the first dose administered 30 minutes before the start of chemotherapy, and subsequent doses 4 and 8 hours after the first dose; then 4 mg orally 3 times a day (every 8 hours) for 1 to 2 days after the completion of chemotherapy. 12 years and older: ...
How long before chemo do you give emetogenic chemotherapy?
Parenteral: -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose. -Maximum dose: 16 mg per dose. Comments: