Is gentian violet a carcinogen?
On November 1, 2018, the CIC is scheduled to deliberate on the carcinogenicity of gentian violet. OEHHA developed this document with information on the evidence of carcinogenicity of gentian violet to assist the CIC in its deliberations.
Why is gentian violet incubated with banked blood?
As an antitrypanosomal agent, gentian violet has been incubated with banked blood prior to transfusion to prevent transmission of Chagas disease in endemic areas such as Latin America (Ramirez et al. 1995; Vilaseca et al. 1966).
Does gentian violet bind to DNA?
The data show that gentian violet binds to DNA, and this, together with the cellular toxicity of gentian violet, complicates both the testing of gentian violet in vitro and the interpretation of the results. The results are somewhat varied in Salmonella typhimurium
What is gentian violet (gentian violet)?
Gentian violet is a direct-acting electrophile that reacts with DNA and other nucleophiles ( Muller and Gautier 1975; NCTR 1983). Gentian violet also forms electrophilic metabolites.
What kind of cancer does gentian violet cause?
Carcinogenicity of gentian violet Tumours were observed in various organs (e.g. liver, thyroid, reproductive organs) following two years of oral exposure to mid to high doses (up to 600ppm) of GV in rats and mice.
How toxic is gentian violet?
Surprisingly, no acute toxic side effects were reported after administration of large amounts of gentian violet-treated blood. No studies have been done on long-term effects (chronic toxicity, carcinogenicity) of gentian violet-treated blood either in humans or in laboratory animals.
Is gentian violet safe to use?
High concentrations of gentian violet have been associated with skin irritation, especially of the lining of the eyes, gastrointestinal tract, and genital tract. Always use low-concentration doses. Toxicity. Gentian violet has been linked to nausea, vomiting, diarrhea, and abdominal pain.
Is gentian violet FDA approved?
--Gentian violet is generally recognized as safe and effective by FDA as an over-the-counter (nonprescription) drug for human use, primarily for the treatment of pinworms.
Is gentian violet carcinogenic?
Gentian violet, leucomalachite green, and CI Direct Blue 218 were classified as “possibly carcinogenic to humans” (Group 2B) on the basis of “sufficient” evidence of carcinogenicity in experimental animals.
What is gentian violet 1% used for?
Gentian violet belongs to the group of medicines called antifungals. Topical gentian violet is used to treat some types of fungus infections inside the mouth (thrush) and of the skin. Gentian violet is available without a prescription.
Can I put gentian violet on my nipples?
We believe that gentian violet is the best treatment of nipple soreness due to Candida albicans for the breastfeeding mother. This is because it works almost always, and relief is rapid. It is messy, and will stain clothing, but not skin.
What can I use instead of gentian violet?
During Orientation Week 2019, student leaders in the Faculty of Engineering and Applied Science used ProAiir Hybrid Face and Body FX Paint, left, as a safe alternative to gentian violet, right, used in previous years.
Is gentian violet safe for oral thrush?
Although gentian violet is a safe and effective thrush treatment, there are some drawbacks with its use. For example, it can stain the mouth, skin, and clothing very easily.
Does gentian violet cure toenail fungus?
Plus: gentian violet can help improve toenail fungus, but it's a strong blue dye that can stain skin and nails.
Does Walmart carry gentian violet?
Sanvall Gentian Violet 1 % Solution, 1 oz - Walmart.com.
What is the active ingredient in gentian violet?
Uses - Topical antiseptic as first aid to help - prevent infection in minor cuts, scrapes - and burns. and burns....Drug Label Information.Active Ingredient/Active MoietyIngredient NameBasis of StrengthStrengthGENTIAN VIOLET (UNII: J4Z741D6O5) (GENTIAN VIOLET CATION - UNII:3GVJ31T6YY)GENTIAN VIOLET1 g in 100 mL
Is gentian violet safe for oral thrush?
Although gentian violet is a safe and effective thrush treatment, there are some drawbacks with its use. For example, it can stain the mouth, skin, and clothing very easily.
Can I put gentian violet on my nipples?
We believe that gentian violet is the best treatment of nipple soreness due to Candida albicans for the breastfeeding mother. This is because it works almost always, and relief is rapid. It is messy, and will stain clothing, but not skin.
How long can you use gentian violet for thrush?
For topical solution dosage form: For fungus infections: Adults and children—Apply to the affected area(s) of the skin two or three times a day for three days.
How do I get gentian violet off my baby's lips?
Apparently rubbing alcohol or vodka on a cotton swab will remove some of the staining. You can prevent or at least reduce the staining by using some vaseline or olive oil on your babies lips before using the Gentian Violet.
Issue
OTTAWA - Health Canada has completed a safety review of human health products and veterinary drugs containing gentian violet and has found that exposure to these products may increase the risk of cancer.
What you should do
Stop using all drug products that contain gentian violet, including on animals. Products for humans should be returned to a pharmacy for proper disposal. Animal owners can discuss options for the safe disposal of their products with their veterinarians or local pharmacies.
What Health Canada is doing
Health Canada worked with all manufacturers with licensed drug products containing gentian violet to remove them from the market.
