What is the Rf value for aspirin and ibuprofen?
The Rf value for the Ibuprofen was ~0.56, ~0.47 for acetaminophen, ~0.16 for caffeine, and ~2.7 for aspirin. Click to see full answer. Likewise, people ask, what is the RF value for aspirin? The hardiness of the method is evidenced by the Rf values, which vary by no more than 3% over a four-month period.
What is the coefficient of variation for ibuprofen?
The standard deviation and coefficient of variation were 1.82 and 0.252, respectively for ethambutol and 1.61 and 0.432, respectively for ibuprofen. The direct isocratic method requires no separation of drug from other active ingredients, and does not require any derivatization.
How accurate is the recovery rate of ibuprofen?
Recoveries of ibuprofen from a new pilot prepn spiked to contain 4, 5, and 6% of the drug were 100.4, 100.3, and 99.7%, resp. The precision at each concn was <0.8%. The analysis of ibuprofen degradation products showed that the method also provides an indication of the stability of the drug.
What is the volume of distribution of ibuprofen?
The apparent volume of distribution of ibuprofen is of 0.1 L/kg. The clearance rate ranges between 3-13 L/h depending on the route of administration, enantiomer type and dosage. Ibuprofen is rapidly absorbed after oral admin, & peak concns in plasma are observed after 15-30 min.
What is the Rf value for acetaminophen?
The Rf values of the isolated acetaminophen, pure acetaminophen and Excedrin were all within 0.06. This is most likely due to the contamination of the TLC plate with Excedrin.
What is the Rf value of caffeine?
The Rf value of caffeine standard was 0.63, and every sample showed similar value with caffeine standard, indicating that all samples contain caffeine.
How do you calculate Rf values?
1:146:36Calculating Rf Values - YouTubeYouTubeStart of suggested clipEnd of suggested clipSo if we wanted to calculate the RF of a. You would take the distance traveled by a over theMoreSo if we wanted to calculate the RF of a. You would take the distance traveled by a over the distance traveled by the solvent call that s and here that's equal to two over four.
What is the Rf value of Salicylamide?
Acetaminophen: Rf = 0.61 Acetylsalicylic: Rf = 0.77 Caffeine: Rf = 0.17 Phenacetin: Rf = 0.69 Salicylamide: Rf = 0.62 Based on the Rf values, which analgesic is the most polar?
What is the Rf of aspirin?
The Rf values are 0.70 for salicylic acid and diflunisal, 0.67 for aspirin and methyl salicylate, 0.60 for gentisic acid, 0.57 for p-aminosalicyclic acid, and 0.40 for salicyluric acid.
Is aspirin more polar than acetaminophen?
Acetaminophen has a phenol and amide function group, but caffeine has multiple amide functional groups; therefore, acetaminophen is more polar than aspirin and less polar than caffeine.
Can Rf value be greater than 1?
By definition, Rf values are always less than 1. An Rf value of 1 or too close to it means that the spot and the solvent front travel close together and is therefore unreliable.
What is a good Rf value?
The best Rf (retention or retardation factor) lies between 0.3 and 0.7. If you want the Rf of your TLC spot to be smaller, i.e., the spot to be lower down on the plate, you must decrease the eluent polarity.
What do Rf values mean?
retardation valuesRf values are the retardation values in a specific environment for a particular analyte (solute). These values aren't good or bad. These are just a ratio of two migration distances occurring simultaneously, the analyte and the solvent front.
Is aspirin more polar than ibuprofen?
(Acetaminophen; Aspirin; Caffeine, and Ibuprofen) D cafteine > Acetaminophen > phenacetin > Aspirin> ibuprofen Aspirin is more polar than ibuprofen more H bond acceptors and donators acetamingghen phenacetin it has a OH that can H bond .
What is the Rf value of 4 aminophenol?
The Rf values were 0.18, 0.34, 0.69 and 0.76 for PAR, 4-AP, LOR and PSH, respectively.
What is the polarity of aspirin?
Aspirin is a polar molecule with dipole-dipole attraction bonds and an -OH (hydroxyl) segment as part of a carboxylic acid group. This makes it easily dissoluble in other polar liquids, such as water (H2O) and blood plasma.
What is the Rf value?
In thin-layer chromatography, the retention factor (Rf) is used to compare and help identify compounds. The Rf value of a compound is equal to the distance traveled by the compound divided by the distance traveled by the solvent front (both measured from the origin).
What is the lambda max of caffeine?
273 nmIn this study first method involved the simultaneous equation method and absorption of caffeine was recorded at 273 nm (λ max), while the other method involves the formation of Q-absorbance equation at isosbestic point at 259.5 nm. From both methods linearity concentration range was 2–2.3 μg/mL for caffeine.
What does a high Rf value mean?
The fastest moving spot has the highest Rf value. Therefore Rf values and polarity are inversely related. The spot with the highest Rf value is the least. polar (fastest moving), and the spot with the lowest Rf value is the most polar (slowest moving).
Why might it be very difficult to visualize the separation?
Why might it be very difficult to visualize the separation of Cis and Trans 2-Butene by TLC? The butenes are very volatile and will evaporate before they can be detected.
How does ibuprofen release to the atmosphere?
Ibuprofen's production and use as anti-inflammatory, analgesic, and antipyretic may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 4.7X10-5 Hg at 25 °C indicates ibuprofen will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase ibuprofen will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 32 hrs. Particulate-phase ibuprofen will be removed from the atmosphere by wet and dry deposition. If released to soil, ibuprofen is expected to have slight mobility based upon an estimated Koc of 3,400. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 1.5X10-7 atm-cu m/mole. The pKa of ibuprofen is 4.91, indicating that this compound will primarily exist in the dissociated form in the environment and anions generally do not adsorb to organic carbon and clay more strongly than their neutral counterparts. If released into water, ibuprofen is expected to adsorb to suspended solids and sediment based upon the estimated Koc. A half-life of 20 days using water samples from lake Greifensee, Switzerland indicates that biodegradation may be an important environmental fate process. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. Volatilization from water surfaces is not expected to be an important fate process since ibuprofen will be mostly found in the anionic form at pH values of 5 to 9. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected be an important environmental fate process as carboxylic acids are generally resistant to hydrolysis. Occupational exposure to ibuprofen may occur through inhalation and dermal contact with this compound at workplaces where ibuprofen is produced or used. Monitoring data indicate that the general population may be exposed to ibuprofen via intentional oral ingestion for medicinal purposes, ingestion of drinking water, and dermal contact with this compound and other consumer products containing ibuprofen. (SRC)
What is the name of the drug that is used to treat groundwater?
GROUNDWATER: Ibuprofen is one of the drugs earmarked by the US Geological Survey for inclusion in a survey of 80 groundwater sources (1).
How long does ibuprofen last?
The serum half-life of ibuprofen is 1.2-2 hours. In patients with a compromised liver function , the half-life can be prolonged to 3.1-3.4 hours.
What is the BCF of ibuprofen?
An estimated BCF of 3 was calculated for ibuprofen (SRC), using a log Kow of 3.97 (1) and a regression-derived equation (2). According to a classification scheme (3), this BCF suggests the potential for bioconcentration in aquatic organisms is low (SRC).
How is ibuprofen metabolized?
Ibuprofen is rapidly metabolized and biotransformed in the liver to the formation of major metabolites which are the hydroxylated and carboxylated derivatives. As soon as it is absorbed, the R-enantiomer undergoes extensive enantiomeric conversion (53-65%) to the more active S-enantiomer _in vivo_ by the activity of alpha-methylacyl-CoA racemase. Ibuprofen metabolism can be divided in phase I which is represented by the hydroxylation of the isobutyl chains for the formation of 2 or 3-hydroxy derivatives followed by oxidation to 2-carboxy-ibuprofen and p-carboxy-2-propionate. These oxidative reactions are performed by the activity of the cytochrome P450 isoforms CYP 2C9, CYP 2C19 and CYP 2C8. Therefore, these enzymes participate in the oxidation of the alkyl side chain to hydroxyl and carboxyl derivatives. From this enzymes, the major catalyst in the formation of oxidative metabolites is the isoform CYP 2C9. The metabolic phase I is followed by a phase II in which the oxidative metabolites may be conjugated to glucuronide prior to excretion. This activity forms phenolic and acyl glucuronides.
How long does it take for ibuprofen to be eliminated?
It is completely eliminated in 24 hours after the last dose and almost all the administered dose goes through metabolism, representing about 99% of the eliminated dose.
What is ibuprofen indicated for?
Ibuprofen ... /is/ indicated for reduction of fever. /Included in US product labeling/
What is the Rf value of gentisic acid?
The Rf values are 0.70 for salicylic acid and diflunisal, 0.67 for aspirin and methyl salicylate, 0.60 for gentisic acid, 0.57 for p-aminosalicyclic acid, and 0.40 for salicyluric acid.
What is the RF value of paracetamol?
Also Know, what is the RF value of paracetamol? The solvent system was found to give compact spot for chlorzoxazone (Rf values of 0.23 ± 0.021), diclofenac sodium (Rf values of 0.51 ± 0.035) and paracetamol (Rf values of 0.64 ± 0.028) .
What is the Rf value of pure caffeine?
While the Rf value from the analysis of pure caffeine is 0.70; 0.71; 0.72. The Rf values which indicate the results of the qualitative analysis of pure caffeine.
