what is sodium acetylsalicylate

What is sodium salicylate?

Jan 21, 2020 · Sodium acetylsalicylate, also known as sodium aspirinate, is the sodium salt of acetylsalicylic acid. It is an easy-to-make compound used in the production of other acetylsalicylate salts.

What is the generic name for acetylsalicylic acid?

Aspirin sodium. Sodium acetylsalicylate. Sodium O-acetylsalicylate. 493-53-8. UNII-E62HT5S2E9. sodium;2-acetyloxybenzoate. Sodium aspirin. E62HT5S2E9. Aspirin-natrium. Aspirin-natrium [German] Sodium acetylsalicylic acid. Acetylsalicylic acid sodium salt. O-Acetylsalicylic acid, sodium salt. EINECS 207-777-7. Salicylic acid, acetate, sodium salt

What is the EMA code for acetylsalicylat?

Mar 08, 2011 · Sodium acetylsalicylic acid is more soluble in water than acetylsalicylic acid because it dissociates into ions (Na+ and the acetylsalicylate anion) which then attract water molecules to form ...

What is aspirin (acetylsalicylic acid)?

1. a monosodium salt of phosphoric acid; used in buffer solutions, as a urinary acidifier, as a laxative, and as a source of phosphorus in hypophosphatemia, often in combination with potassium phosphate. 2. a monosodium salt of phosphoric acid; used in buffer solutions.

Is sodium salicylate the same as aspirin?

Is sodium salicylate harmful?

Is Acetylsalicylate a salt?

Is sodium Acetylsalicylate aspirin?

Can you take sodium salicylate and Tylenol together?

Is sodium salicylate good for skin?

What happens when you add HCl to sodium Acetylsalicylate?

Is sodium Acetylsalicylate soluble?

Does aspirin react with Naoh?

In which schedule aspirin sodium comes under?

Why is aspirin sold in its sodium salt?

What is salicylic acid chemistry?

Is aspirin a non-steroidal anti-inflammatory?

A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate.

What are anti-inflammatory agents?

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibi tion of prostaglandin synthes is accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal .)

What is a FCN?

According to Section 409 (h) (1) (C) of the Federal Food, Drug, and Cosmetic Act, food contact substance notifications (FCNs) are effective only for the listed manufacturer and its customers. Other manufacturers must submit their own FCN for the same food contact substance and intended use.

What is sodium salicylate?

Chemical compound. Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by refluxing methyl salicylate ( wintergreen oil) with an excess of sodium hydroxide.

Is sodium salicylate a NSAID?

It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It is also a potential replacement for aspirin for people sensitive to it.

Can you give sodium salicylate to children?

Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19.

How much sodium salicylate is in a vial?

Sodium salicylate (SS; Saliject, Omega Laboratories, Montreal, Canada) is provided in a 10-mL multiuse vial. Each milliliter contains 570 mg of SS, with benzyl alcohol 1% and sodium metabisulfite 0.1% added as preservatives. Because SS is painful on injection, especially if it diffuses or is injected extravascularly, it is recommended to be diluted with lidocaine 1% without epinephrine. The manufacturer recommends a maximum daily total quantity of 8 to 10 mL. It may also be added to other sclerosing solutions such as glycerin to achieve a final concentration between 6% and 30%. In this concentration, it can be used for telangiectasias less than 1 mm in diameter.

What is the difference between aspirin and sodium salicylate?

As such, it does not have a two-compartment half-life as does aspirin. That is, although aspirin has a “first” half-life as acetylsalicylic acid that is approximately 15 minutes followed by an active metabolite, salicylate, half-life of 3 to 5 hours, sodium salicylate has a single compartment active drug half-life of 3 to 5 hours, but can be prolonged up to 19 hours. 13 The second major difference between aspirin and sodium salicylate is that aspirin acetylates and irreversibly blocks cyclooxgenase. Therefore, platelet aggregation is effectively inhibited for the life of the platelet with aspirin, whereas the antiplatelet adhesion effect is only temporary with the nonacetylated salicylates.

How does salicylate transport?

Salicylate is actively transported by a low-capacity, saturable system out of the cerebrospinal fluid across the choroid plexus.

Does sodium salicylate increase urea nitrogen?

Sodium salicylate causes increases in blood urea nitrogen concentration and excretion of glucose, protein, blood, and tubular epithelial cells in urine of humans as well as experimental animals (Arnold et al. 1973;

Does aspirin inhibit cyclooxygenases?

At least two different types of cyclooxygenases, COX-1 and COX-2, are acted on by aspirin. Aspirin irreversibly inhibits COX-1 and modifies the enzymatic activity of COX-2. COX-2 normally produces prostanoids, most of which are proinflammatory. Aspirin-modified PTGS2 ( Prostaglandin-endoperoxide synthase 2) produces lipoxins, most of which are anti-inflammatory. Newer NSAID drugs, COX-2 inhibitors (coxibs), have been developed to inhibit only PTGS2, with the intent to reduce the incidence of gastrointestinal side effects.

What is the melting point of aspirin?

Physical properties. Aspirin, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, with a melting point of 136 °C (277 °F), and a boiling point of 140 °C (284 °F). Its acid dissociation constant ( p Ka) is 3.5 at 25 °C (77 °F).

How many milligrams of aspirin are in a tablet?

Smaller doses are based on these standards, e.g., 75 mg and 81 mg tablets. The 81-milligram ( 1. +.

Does aspirin cause bleeding?

Gastrointestinal. Enteric-coated 325 mg aspirin pills. Aspirin use has been shown to increase the risk of gastrointestinal bleeding. Although some enteric-coated formulations of aspirin are advertised as being "gentle to the stomach", in one study, enteric coating did not seem to reduce this risk.

What is the purpose of aspirin?

Aspirin, also known as acetylsalicylic acid ( ASA ), is a medication used to reduce pain, fever , or inflammation. Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin given shortly after a heart attack decreases the risk of death.

Is aspirin a generic?

Today, aspirin is a generic trademark in many countries. Aspirin, with a capital "A", remains a registered trademark of Bayer in Germany, Canada, Mexico, and in over 80 other countries, for acetylsalicylic acid in all markets, but using different packaging and physical aspects for each.

Does aspirin break down?

Aspirin is readily broken down in the body to salicylic acid, which itself has anti-inflammatory, antipyretic, and analgesic effects. In 2012, salicylic acid was found to activate AMP-activated protein kinase, which has been suggested as a possible explanation for some of the effects of both salicylic acid and aspirin.

What acid is used to synthesize aspirin?

Synthesis of Aspirin (acetylsalicylic acid) Salicylic acid will rapidly react with acetic anhydride in the presence of an acid catalyst to produce aspirin (acetylsalicylic acid) and acetic acid (ethanoic acid). Sulfuric acid or phosphoric acid are often used to catalyse the reaction. salicylic acid. +.

Is aspirin a carboxylic acid?

Aspirin (acetylsalicylic acid) is an aromatic compound containing both a carboxylic acid functional group and an ester functional group. Aspirin is a weak acid that is only slightly soluble in water. Aspirin can be prepared by reacting salicylic acid and acetic anhydride in the presence of an acid catalyst.

Is aspirin an analgesic?

Key Concepts. Aspirin is widely used as an analgesic (pain reliever) and an antipyretic (for reducing fever). It is also used to help prevent heart attacks, strokes, and blood clot formation in people at risk of developing blood clots. Aspirin (acetylsalicylic acid) is an aromatic compound containing both a carboxylic acid functional group ...

What is the purpose of aspirin?

It is also used to help prevent heart attacks, strokes, and blood clot formation in people at risk of developing blood clots. Aspirin (acetylsalicylic acid) is an aromatic compound containing both a carboxylic acid functional group and an ester functional group.

Is aspirin a weak acid?

Aspirin (acetylsalicylic acid) is an aromatic compound containing both a carboxylic acid functional group and an ester functional group. Aspirin is a weak acid that is only slightly soluble in water.

Is aspirin soluble in water?

Aspirin is more soluble in basic (alkaline) solutions, so it readily dissolves in the duo denum which is the first part of the intestine. Ionic salts of aspirin, such as sodium acetylsalicylate, are more soluble in water since they form stronger ion-dipole interactions with water .

What is the reaction of aspirin?

Reactions of Aspirin (acetylsalicylic acid) The neutralization reaction can be used to determine the amount of aspirin (acetylsalicylic acid) present in commercially available aspirin tablets using a back (indirect) titration method.