Bicytopenia is the reduction of any of the two cell lines of blood, i.e., erythrocytes, leukocytes or platelets. Many studies are done on pancytopenia but very few studies exist in the literature evaluating the spectrum of aetiologies of bicytopenia. To date, no study is available on bicytopenia in adults.
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What is the most common aetiology of bicytopenia?
The most common aetiology of bicytopenia was found to be non-malignant (56%) followed by infectious (31.7%), malignant (8.3%) and drug-induced (4%). Megaloblastic anaemia was the predominant aetiology among the non-malignant group, closely followed by immune thrombocytopenic purpura and alcoholic liver disease.
What is pancytopenia?
Pancytopenia happens when all three types of blood cells are at reduced production levels. This can be extremely dangerous for your body, as pancytopenia makes you susceptible to all of the issues that we’ve listed above. Now that you know about the different types of cytopenia, you may be wondering what actually causes cytopenia.
What is cytopenia in medical terms?
Noun. bicytopenia (countable and uncountable, plural bicytopenias) (medicine) A deficiency in two of the three cell lines in the blood, namely erythrocytes, leukocytes and platelets. Click to see full answer. Accordingly, what causes cytopenia?
What causes thrombocytopenia?
Thrombocytopenia Thrombocytopenia is characterized by a lack of platelet production in the bone marrow. Since the platelets play a significant role in clotting and bleeding, thrombocytopenia can cause even a small cut to bleed profusely.
What is meant by Bicytopenia?
Bicytopenia is the reduction of any of the two cell lines of blood, i.e., erythrocytes, leukocytes or platelets. Many studies are done on pancytopenia but very few studies exist in the literature evaluating the spectrum of aetiologies of bicytopenia.
How do you treat Bicytopenia?
However, many patients undergoing treatment for either of these diseases may experience lower blood cell counts as a result of the treatment. Corticosteroids are often the first-line treatment for several types of cytopenia....Treatmentimmunosuppressive therapy.bone marrow transplant.blood transfusion.splenectomy.
What is the difference between pancytopenia and Bicytopenia?
Broadly speaking, pancytopenia refers to a decrease in all three cell lines, while bicytopenia refers to decrease in any two of the three cell lines. Bicytopenia is commonly the result of two pathologies or represents a stage in a developing pancytopenia.
What are 5 causes of pancytopenia?
There are many different conditions that can cause pancytopenia....Some possible causes of pancytopenia include:Cancer.Lupus.Bone marrow disorders.Infections.Side effects of medicine.Exposure to toxins such as radiation, arsenic, or benzine.Chemotherapy treatments.Radiation treatments.More items...•
What are two conditions that cause polycythemia?
The most common causes of secondary polycythemia include obstructive sleep apnea, obesity hypoventilation syndrome, and chronic obstructive pulmonary disease (COPD). Other causes include testosterone replacement therapy and heavy cigarette smoking.
What are the symptoms of thrombocytopenia?
SymptomsEasy or excessive bruising (purpura)Superficial bleeding into the skin that appears as a rash of pinpoint-sized reddish-purple spots (petechiae), usually on the lower legs.Prolonged bleeding from cuts.Bleeding from your gums or nose.Blood in urine or stools.Unusually heavy menstrual flows.Fatigue.More items...•
Can the Covid vaccine cause pancytopenia?
We report a 74-year-old male who developed bone marrow suppression and pancytopenia recorded seven days after receiving the Pfizer SARS-CoV-2 vaccine. During his hospital stay, the patient's hemoglobin, white blood cell, and platelet levels continued to trend downwards.
Can Vitamin B12 deficiency cause pancytopenia?
Deficiency of vitamin B12 is a well known cause of megaloblastic anemia and pancytopenia. Splenomegaly and leukoerythroblastosis are much less well known manifestations of B12 deficiency.
What is the most common drug that causes pancytopenia?
Chemotherapeutic agents, chloramphenicol, sulfa drugs, gold, nonsteroidal antiinflammatory drugs, certain antiepileptic drugs, ionizing radiation, benzene, and various other drugs have been associated with aplastic anemia. iii. Infections. Parvovirus B19 is the most frequently documented viral cause of aplastic anemia.
Is pancytopenia serious?
Pancytopenia is serious and should not be ignored. Without treatment, it can lead to life-threatening symptoms that affect the entire body such as oxygen shortage and immune system problems.
Who is at risk for pancytopenia?
A family history of pancytopenia, cancer, or immunodeficiencies may also increase the risk of developing this issue. A 2021 article states that pancytopenia is more common in children and adults in their 30s or 40s. It is also more common in males than females.
Is pancytopenia a form of leukemia?
Pancytopenia is the reduction in the number of all 3 major cellular elements of blood and leads to anemia, leukopenia, and thrombocytopenia. A wide variety of etiologies result in pancytopenia including leukemia, aplastic anemia, and megaloblastic anemia.