UniProtKB/Swiss-Prot
- Protein and gene names
- Function
- Enzyme -specific information such as catalytic activity, cofactors and catalytic residues
- Subcellular location
- Protein-protein interactions
- Pattern of expression
- Locations and roles of significant domains and sites
- Ion -, substrate - and cofactor-binding sites
Full Answer
What is UniProtKB Swiss-Prot database?
UniProtKB/Swiss-Prot is the manually annotated and reviewed section of the UniProt Knowledgebase (UniProtKB). It is a high quality annotated and non-redundant protein sequence database, which brings together experimental results, computed features and scientific conclusions.
What are the differences between UniProtKB Swiss-Prot and UniProtKB TrEMBL?
UniProtKB/Swiss-Prot is manually curated which means that the information in each entry is annotated and reviewed by a curator, while the records in UniProtKB/TrEMBL are automatically generated and are enriched with automatic annotation and classification.29-Mar-2011
Why is UniProtKB composed of 2 sections UniProtKB Swiss-Prot and UniProtKB TrEMBL?
These UniProtKB/TrEMBL unreviewed entries are kept separated from the UniProtKB/Swiss-Prot manually reviewed entries so that the high quality data of the latter is not diluted in any way. Automatic processing of the data enables the records to be made available to the public quickly.10-Apr-2018
What are the components of UniProtKB?
UniProt is comprised of four major components, each optimized for different uses: the UniProt Knowledgebase, the UniProt Reference Clusters, the UniProt Archive and the UniProt Metagenomic and Environmental Sequences database.
What is the difference between Swiss-Prot and TrEMBL?
TrEMBL consists of entries in a SWISS-PROT format that are derived from the translation of all coding sequences in the EMBL nucleotide sequence database, that are not in SWISS-PROT. Unlike SWISS-PROT entries those in TrEMBL are awaiting manual annotation.
How do I use UniProtKB?
10:0127:56A guide to UniProt for students - YouTubeYouTubeStart of suggested clipEnd of suggested clipSimply input your sequence of interest into it or any uniprot identified into the search box thenMoreSimply input your sequence of interest into it or any uniprot identified into the search box then click blast.
What is Swiss-Prot in bioinformatics?
SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases.
What is different between reviewed and unreviewed entries?
Reviewed (Swiss-Prot) – contains manually annotated records. Unreviewed (TrEMBL) – contains computationally analysed records.
Is Swiss-Prot manually annotated?
The Swiss-Prot section of the UniProt KnowledgeBase (UniProtKB/Swiss-Prot) contains publicly available expertly manually annotated protein sequences obtained from a broad spectrum of organisms.
How reliable is UniProt?
UniProtKB encompasses several individual protein sequence resources that are depicted on this page. If you are talking about a sequence that is from SwissProt (manually reviewed/curated sequences) or UniRef100 clusters then that sequence is likely perfectly accurate.26-Oct-2018
Why do we use UniProt?
UniProt helps with this in the following ways: It provides an up-to-date, comprehensive body of protein information at a single site. It aids scientific discovery by collecting, interpreting and organising this information so that it is easy to access and use. ... It provides tools to help with protein sequence analysis.
How do you cite Pdbsum?
PDBsum is a database that provides an overview of the contents of each 3D macromolecular structure deposited in the Protein Data Bank....PDBsum.ContentAuthorsRoman Laskowski & al. (1997)Primary citationPMID 9433130AccessWebsitewww.ebi.ac.uk/pdbsum/8 more rows
Focus on the group's mission
The Swiss-Prot team excels in the art of generating machine-readable knowledge of biology from the ever growing body of scientific publications. It is harnessing the power of deep learning to accelerate literature triage and information extraction, thus delivering the most accurate and informative evidence to users in a timely manner.
Biocuration and software development
We organize, clean & control the quality of your datasets for subsequent analysis. In addition, we can process, transform and align your datasets to existing standards and make them available as a database. We can propose different data storage solutions depending on project needs (e.g. federated versus integrated).
Supporting AI with machine-readable biological knowledge
Knowledgebases like UniProtKB are an essential part of the AI ecosystem; the collective biological knowledge they contain, in the form of pathways, ontologies and networks, can be used to create generalizable and interpretable models that reveal actionable biological mechanisms.
Publications
Parit Bansal, Anne Morgat, Kristian B Axelsen, Venkatesh Muthukrishnan, Elisabeth Coudert, Lucila Aimo, Nevila Hyka-Nouspikel, Elisabeth Gasteiger, Arnaud Kerhornou, Teresa Batista Neto, Monica Pozzato, Marie-Claude Blatter, Alex Ignatchenko, Nicole Redaschi, Alan Bridge. Rhea, the reaction knowledgebase in 2022.