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uniprot kb

by Xavier Williamson Published 3 years ago Updated 2 years ago

What is UniProt KnowledgeBase?

Getting started Text search Our basic text search allows you to search all the resources available. BLAST Find regions of similarity between your sequences. Sequence alignments Align two or more protein sequences using the Clustal Omega program. Retrieve/ID mapping Batch search with UniProt IDs or convert them to another type of database ID (or vice versa). Peptide search …

What is UniProtKB/SWISS-PROT?

It consists of: UniProtKB/Swiss-Prot (expert-curated records) and UniProtKB/TrEMBL (computationally annotated records). UniProtKB is produced by the UniProt consortium. Developed by the Swiss-Prot group and UniProt partners at EMBL-EBI and PIR, and supported by the SIB Swiss Institute of Bioinformatics. UniProt is an ELIXIR Core Data Resource.

What does UniProtKB stand for?

UniProtKB/Swiss-Prot is the expertly curated component of UniProtKB (produced by the UniProt consortium). It contains hundreds of thousands of protein descriptions, including function, domain structure, subcellular location, post-translational modifications and functionally characterized variants. 💡 UniProt is one of the most widely used ...

Where are the protein sequences provided by UniProtKB derived?

UniProtKB. x; UniProtKB. Protein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. Proteomes. Protein sets from fully sequenced genomes. Annotation systems. Systems used to automatically annotate proteins with high accuracy: UniRule ...

What is UniProtKB used for?

UniProtKB/Swiss-Prot is a manually annotated, non-redundant protein sequence database. It combines information extracted from scientific literature and biocurator-evaluated computational analysis. The aim of UniProtKB/Swiss-Prot is to provide all known relevant information about a particular protein.

What is UniProtKB in bioinformatics?

The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data.02-Feb-2021

What is UniProt KB?

The UniProt Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation.28-Jan-2021

What is UniProtKB Swiss-Prot database?

UniProtKB/Swiss-Prot is the manually annotated and reviewed section of the UniProt Knowledgebase (UniProtKB). It is a high quality annotated and non-redundant protein sequence database, which brings together experimental results, computed features and scientific conclusions.

What are the components of UniProtKB?

UniProt is comprised of four major components, each optimized for different uses: the UniProt Knowledgebase, the UniProt Reference Clusters, the UniProt Archive and the UniProt Metagenomic and Environmental Sequences database.

How do I use UniProtKB?

10:0127:56A guide to UniProt for students - YouTubeYouTubeStart of suggested clipEnd of suggested clipSimply input your sequence of interest into it or any uniprot identified into the search box thenMoreSimply input your sequence of interest into it or any uniprot identified into the search box then click blast.

What is TrEMBL?

Introduction TrEMBL is a computer-annotated protein sequence database supplementing the SWISS-PROT Protein Sequence Data Bank. TrEMBL contains the translations of all coding sequences (CDS) present in the EMBL Nucleotide Sequence Database not yet integrated in SWISS-PROT.01-Jan-1999

What is uniref50?

The UniProt Reference Clusters (UniRef) provide clustered sets of sequences from the UniProt Knowledgebase (including isoforms) and selected UniParc records in order to obtain complete coverage of the sequence space at several resolutions while hiding redundant sequences (but not their descriptions) from view.30-Jun-2020

What are the differences between UniProtKB Swiss-Prot and UniProtKB TrEMBL?

UniProtKB/Swiss-Prot is manually curated which means that the information in each entry is annotated and reviewed by a curator, while the records in UniProtKB/TrEMBL are automatically generated and are enriched with automatic annotation and classification.29-Mar-2011

Is Swiss-Prot a primary database?

Hint: A primary database is one that makes information available to the public. The secondary databases take this information on sequences to then add layers to the existing DNA sequence and protein sequence data. Complete answer: SWISS PROT is a protein sequence database.

How do I access Swiss-Prot?

There are multiple sites on the Web that can access the Swiss-Prot/TrEMBL and retrieve the database. Its main sites are the ExPASy Molecular Biology website (http://www.expasy.org/) and the European Institute of Bioinformatics (EBI) website (http://www.ebi.ac.uk/swissprot/).

What is the difference between Swiss-Prot and TrEMBL?

TrEMBL is a computer-annotated supplement of SWISS-PROT that contains all the translations of EMBL nucleotide sequence entries, which are not yet integrated in SWISS-PROT. Currently, SWISS-PROT and TrEMBL have 0.5 and 7.6 million sequences, respectively.

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