What is UniProt?
What does UNIPROT abbreviation stand for? List of 2 best UNIPROT meaning forms based on popularity. Most common UNIPROT abbreviation full forms updated in February 2022
What does UniProtKB stand for?
The UniProt (Universal Protein Resource) Consortium is comprised of the European Bioinformatics Institute, the Swiss Institute of Bioinformatics and the Protein Information Resource. The UniProt consortium aims to support biological research by maintaining a high quality database that serves as a stable, fully
What is the'basket'in the UniProt KnowledgeBase?
have united to form the Universal Protein Knowledgebase (UniProt) consor tium. Our mission is to provide a comprehensive, fully classi®ed, richly and accurately annotated protein sequence...
What are the UniProt reference clusters?
The Universal Protein Resource (UniProt) provides a stable, comprehensive, freely accessible, central resource on protein sequences and functional annotation. The UniProt Consortium is a collabora-...
What type of database is UniProt?
The UniProt Knowledgebase (UniProtKB) is an expertly curated database, a central access point for integrated protein information with cross-references to multiple sources. The UniProt Archive (UniParc) is a comprehensive sequence repository, reflecting the history of all protein sequences (1).
What is the UniProt code?
UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived from the research literature.
What is UniProt KB?
The UniProt Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation.28-Jan-2021
How big is UniProt database?
The UniProt knowledgebase is a large resource of protein sequences and associated detailed annotation. The database contains over 60 million sequences, of which over half a million sequences have been curated by experts who critically review experimental and predicted data for each protein.28-Nov-2016
How do you read UniProt?
1:2527:56A guide to UniProt for students - YouTubeYouTubeStart of suggested clipEnd of suggested clipWe provide primary sequences. And sequences of ice forms disease variants and sequence specificMoreWe provide primary sequences. And sequences of ice forms disease variants and sequence specific modifications. So providing accurate protein sequence data and information is a primary objective.
How reliable is UniProt?
UniProtKB encompasses several individual protein sequence resources that are depicted on this page. If you are talking about a sequence that is from SwissProt (manually reviewed/curated sequences) or UniRef100 clusters then that sequence is likely perfectly accurate.26-Oct-2018
Why is UniProt used?
The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. EMBL-EBI and SIB together used to produce Swiss-Prot and TrEMBL, while PIR produced the Protein Sequence Database (PIR-PSD). ...02-Feb-2021
Why do we use UniProt?
UniProt helps with this in the following ways: It provides an up-to-date, comprehensive body of protein information at a single site. It aids scientific discovery by collecting, interpreting and organising this information so that it is easy to access and use. ... It provides tools to help with protein sequence analysis.
How many protein sequences are in UniProt?
UniProtKB/Swiss-Prot has curated over 81 000 variants in 13,000 human protein sequence records from peer-reviewed literature, annotated with information on the functional impact and clinical significance, when known.25-Nov-2020
How many sequences are in UniProt?
INTRODUCTION Release 2021_04 of 29-Sep-2021 of UniProtKB/TrEMBL contains 225013025 sequence entries, comprising 78379501201 amino acids.
Is UniProt primary or secondary database?
Many data resources have both primary and secondary characteristics. For example, UniProt accepts primary sequences derived from peptide sequencing experiments.
Is UniProt and Swiss-Prot same?
UniProt provides a comprehensive, high-quality and freely accessible resource of protein sequence and functional information. ... UniProtKB/TrEMBL is a computer-annotated (unreviewed) supplement to Swiss-Prot, which strives to gather all protein sequences that are not yet represented in Swiss-Prot.
What is UniProt database?
UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived from the research literature.
Who is Uniprot funded by?
UniProt is funded by grants from the National Human Genome Research Institute, the National Institutes of Health (NIH), the European Commission, the Swiss Federal Government through the Federal Office of Education and Science, NCI-caBIG, and the US Department of Defense.
What is UniProt consortium?
The UniProt consortium comprises the European Bioinformatics Institute (EBI), the Swiss Institute of Bioinformatics (SIB), and the Protein Information Resource (PIR). EBI, located at the Wellcome Trust Genome Campus in Hinxton, UK, hosts a large resource of bioinformatics databases and services.
Why does Uniparc only store one sequence?
In order to avoid redundancy, UniParc stores each unique sequence only once. Identical sequences are merged, regardless of whether they are from the same or different species. Each sequence is given a stable and unique identifier (UPI), making it possible to identify the same protein from different source databases.
What is a sequence from the same gene and the same species?
Sequences from the same gene and the same species are merged into the same database entry. Differences between sequences are identified, and their cause documented (for example alternative splicing, natural variation, incorrect initiation sites, incorrect exon boundaries, frameshifts, unidentified conflicts).
Where is PIR located?
PIR, hosted by the National Biomedical Research Foundation (NBRF) at the Georgetown University Medical Center in Washington, DC, US, is heir to the oldest protein sequence database, Margaret Dayhoff 's Atlas of Protein Sequence and Structure, first published in 1965.
Does Uniparc contain annotations?
UniParc contains only protein sequences, with no annotation. Database cross-references in UniParc entries allow further information about the protein to be retrieved from the source databases. When sequences in the source databases change, these changes are tracked by UniParc and history of all changes is archived.
Overview
UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived from the research literature. It is maintained by the UniProt consortium, which consists of several European bioinformaticsorganisations and a foundat…
The UniProt consortium
The roots of UniProt databases
Each consortium member is heavily involved in protein database maintenance and annotation. Until recently, EBI and SIB together produced the Swiss-Prot and TrEMBL databases, while PIR produced the Protein Sequence Database (PIR-PSD). These databases coexisted with differing protein sequence coverage and annotation priorities.
Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Insti…
Organization of UniProt databases
UniProt provides four core databases: UniProtKB (with sub-parts Swiss-Prot and TrEMBL), UniParc, UniRef.
UniProt Knowledgebase (UniProtKB) is a protein database partially curated by experts, consisting of two sections: UniProtKB/Swiss-Prot (containing reviewed, manually annotated entries) and UniProtKB/TrEMBL (containing unreviewed, automatically annotated entries). As of 19 March 20…
Funding
External links
• UniProt