What are the benefits of taking tamsulosin?
Response and effectiveness
- Peak concentrations of tamsulosin are reached within four to five hours when a tamsulosin capsule is taken on an empty stomach, or within six to seven hours when tamsulosin is ...
- For most people, the 0.4mg dose of tamsulosin is sufficient. ...
- It may take up to five days of regular dosing before the full effects of tamsulosin on urine flow are achieved.
How long does it take for tamsulosin to work?
How long does it take for tamsulosin to work for kidney stones? The effects of the drug can usually be felt within the first 48 hours. Complete urinary relief may take up to two to six weeks. If a 0.4-mg dose is unable to provide relief, your healthcare provider may recommend that you double the dose to 0.8 mg once daily.
Does tamsulosin work like Viagra?
What is Tamsulosin? Tamsulosin has active ingredients of tamsulosin. It is often used in prostate examination abnormal. eHealthMe is studying from 52,506 Tamsulosin users for its effectiveness, alternative drugs and more. What is Viagra? Viagra has active ingredients of sildenafil citrate. It is often used in erection problems.
What is tamsulosin and what are the long term effects?
- Decreased interest in sexual intercourse
- decreased sexual drive or performance
- drowsiness
- inability to have or keep an erection
- increased cough
- loss in sexual ability, desire, drive, or performance
- nausea
- pain or tenderness around the eyes and cheekbones
- sleepiness or unusual drowsiness
- tooth disorder
What is the function of tamsulosin?
Key facts. Tamsulosin helps reduce the symptoms of an enlarged prostate gland by relaxing the muscles in the bladder and prostate so you can pee more easily. When you first take tamsulosin, it may make you feel dizzy or lightheaded.
How does tamsulosin work for BPH?
It does not shrink the prostate, but it works by relaxing the muscles in the prostate and the bladder. This helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate often or urgently (including during the middle of the night).
Why is tamsulosin given at night?
Dosage for Flomax Take the first dose at bedtime to minimize the chances of getting dizzy or fainting. After the first dose, take your regularly scheduled dose 30 minutes after the same meal each day.
What are the long term effects of tamsulosin?
Tamsulosin side effects long term The researchers found that some of the most common adverse effects included infection, accidental injury, runny nose, pain, and sore throat; other reported side effects included abnormal ejaculation, syncope, and orthostatic hypotension (Narayan, 2005).
Does tamsulosin shrink an enlarged prostate?
Tamsulosin helps relax the muscles in the prostate and the opening of the bladder. This may help increase the flow of urine or decrease the symptoms. However, tamsulosin will not shrink the prostate. The prostate may continue to get larger.
Can an enlarged prostate ever shrink?
Over several months, the body's immune system reabsorbs the dead prostate tissue and replaces it with scar tissue. The scar tissue slowly contracts, resulting in shrinkage of the prostate. Over six months, the prostate will shrink by 20 to 40 percent, resulting in improved and less frequent urination.
Does tamsulosin make you pee more at night?
Tamsulosin reduces nighttime urine production in benign prostatic hyperplasia patients with nocturnal polyuria: a prospective open-label long-term study using frequency-volume chart. Neurourol Urodyn.
Why is tamsulosin taken 30 minutes after a meal?
You should take tamsulosin (Flomax) 30 minutes after the same meal every day. Taking tamsulosin (Flomax) on an empty stomach can cause too much medication to be absorbed, leading to high medication levels in your body.
Does tamsulosin affect sleep?
Djavan et alreported that tamsulosin improves nocturia and sleep disturbances (by increasing the number of hours of undisturbed sleep) in LUTS/BPH [13]. Thus, the results of the present study suggest that the improvement of nocturia by monotherapy with tamsulosin may improve sleep disturbances.
How long should a man take tamsulosin?
The low incidence of acute urinary retention in patients treated with tamsulosin for up to 6 years suggests that tamsulosin may reduce the risk of AUR in patients with BPH.
What happens when you stop taking tamsulosin?
If you stop taking the drug suddenly or don't take it at all: Your BPH symptoms won't improve. If you stop taking this drug for several days, talk to your doctor before starting again. If you miss doses or don't take the drug on schedule: Your medication may not work as well or may stop working completely.
Does tamsulosin affect the kidneys?
Conclusions: The results of the 2 studies indicate that the pharmacokinetics and safety profile of tamsulosin are not significantly influenced by renal or hepatic function. This suggests that no dose adjustment of tamsulosin is necessary in patients with renal or hepatic insufficiency.
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Pharmacology
Tamsulosin is an antagonist of alpha 1A -adrenoreceptors in the prostate. Smooth muscle tone in the prostate is mediated by alpha 1A -adrenoreceptors; blocking them leads to relaxation of smooth muscle in the bladder neck and prostate causing an improvement of urine flow and decreased symptoms of BPH.
Use in Specific Populations
AUC is 40% higher in subjects 55 to 75 years of age compared with subjects 20 to 32 years of age.
Use: Labeled Indications
Benign prostatic hyperplasia: Treatment of signs and symptoms of benign prostatic hyperplasia (BPH)
Contraindications
Hypersensitivity (eg, angioedema, rash, urticaria, pruritus, respiratory symptoms) to tamsulosin or any component of the formulation
Dosage and Administration
Note: Tamsulosin capsules should be administered ~30 minutes following the same meal each day. The controlled-release (oral controlled absorption system [OCAS]) tablet formulation [Canadian product] should be administered at the same time each day with or without food.
Drug Interactions
Alpha-/Beta-Agonists: Alpha1-Blockers may diminish the vasoconstricting effect of Alpha-/Beta-Agonists. Similarly, Alpha-/Beta-Agonists may antagonize Alpha1-Blocker vasodilation. Monitor therapy
What is a tamsulosin?
Tamsulosin, sold under the brand name Flomax among others, is a medication used to treat symptomatic benign prostatic hyperplasia (BPH) and chronic prostatitis and to help with the passage of kidney stones. The evidence for benefit with a kidney stone is better when ...
What receptor is tamsulosin?
Tamsulosin is a selective α 1 receptor antagonist that has preferential selectivity for the α 1A receptor in the prostate versus the α 1B receptor in the blood vessels. When alpha 1 receptors in the bladder neck, the prostate, the ureter, and the urethra are blocked, a relaxation in smooth muscle tissue results.
How long does it take for a 5-alpha-reductase inhibitor to work?
It was approved by the FDA on 14 June 2010. This combination can be useful because it may take up to six months for symptomatic relief to be found when using 5-alpha-reductase inhibitors such as dutasteride compared to alpha-1 receptor blockers, which can provide relief in some cases within 48 hours.
When was tamsulosin approved?
Tamsulosin was approved for medical use in the United States in 1997. It is available as a generic medication. In 2018, it was the 32nd most commonly prescribed medication in the United States, with more than 23 million prescriptions.
When was flomax first marketed?
Tamsulosin was first marketed in 1996 under the trade name Flomax. The U.S. patent expired in October 2009. The U.S. Food and Drug Administration (FDA) approved generics in March 2010. In 2010, tamsulosin was available as OTC medication in UK.
Does tamsulosin cause lightheadedness?
It is taken by mouth. Common side effects include dizziness, headache, sleeplessness, nausea, blurry vision, and sexual problems. Other side effects may include feeling lightheaded with standing and angioedema. Tamsulosin is an alpha blocker and works by relaxing muscles in the prostate.
Does tamsulosin relax the urethral sphincter?
This is because tamsulosin relaxes the muscles of the urethral sphincters, which are normally closed during ejaculation. This side effect can be mitigated by regular pelvic floor (Kegel) exercise and contracting the pelvic floor during ejaculation.
What is tamsulosin metabolized by?
Tamsulosin is extensively metabolized, mainly by CYP3A4 and CYP2D6. Tamsulosin hydrochloride capsules 0.4 mg should not be used in combination with strong inhibitors of CYP3A4 (e.g., ketoconazole) [ see Drug Interactions (7.1) and Clinical Pharmacology (12.3) ]. Tamsulosin hydrochloride capsules should be used with caution in combination with moderate inhibitors of CYP3A4 (e.g., erythromycin), in combination with strong (e.g., paroxetine) or moderate (e.g., terbinafine) inhibitors of CYP2D6, in patients known to be CYP2D6 poor metabolizers particularly at a dose higher than 0.4 mg (e.g., 0.8 mg) [ see Drug Interactions (7.1) and Clinical Pharmacology (12.3) ].
What is the maximum dose of tamsulosin hydrochloride?
Tamsulosin hydrochloride capsules should be used with caution in combination with cimetidine, particularly at a dose higher than 0.4 mg (e.g., 0.8 mg) [ see Drug Interactions (7.1) and Clinical Pharmacology (12.3) ].
What is TS 0.4 mg?
Tamsulosin hydrochloride capsules USP 0.4 mg are supplied in high density polyethylene bottles containing 100 or 500 hard gelatin capsules with white opaque cap and white opaque body, printed with "A02" in black ink on the cap and "TS 0.4mg" in black ink on the body.
How much tamsulosin hydrochloride is used for BPH?
The pharmacokinetics of Tamsulosin hydrochloride have been evaluated in adult healthy volunteers and patients with BPH after single and/or multiple administration with doses ranging from 0.1 mg to 1 mg.
Can you use tamsulosin hydrochloride with other alpha adrene
Tamsulosin hydrochloride capsules should not be used in combination with other alpha adrenergic blocking agents [ see Drug Interactions (7.2) and Clinical Pharmacology (12.3) ]. Caution is advised when alpha adrenergic blocking agents including Tamsulosin hydrochloride are co-administered with PDE5 inhibitors.
Is tamsulosin hydrochloride contraindicated?
Tamsulosin hydrochloride capsules are contraindicated in patients known to be hypersensitive to Tamsulosin hydrochloride or any component of Tamsulosin hydrochloride capsules. Reactions have included skin rash, urticaria, pruritus, angioedema, and respiratory symptoms [ see Adverse Reactions (6.2) ].
Can you chew tamsulosin?
Tamsulosin hydrochloride capsules should not be crushed, chewed or opened. For those patients who fail to respond to the 0.4 mg dose after 2 to 4 weeks of dosing, the dose of Tamsulosin hydrochloride capsules can be increased to 0.8 mg once daily.
How long does tamsulosin last?
No need to adjust the dosage of other antihypertensive drugs when coadministered. Half life of 9-15 hours.
What is the alpha receptor antagonist for prostate smooth muscle?
Tamsulosin. Competitive alpha receptor antagonist that is selective for the α1a & α1d subtypes that are highly expressed in prostate smooth muscle. Has less effect on vascular smooth muscle compared to other alpha-1 blockers. Improves urinary flow rates & symptoms in patients with BPH.
Does tamsulosin affect PSA?
Tamsulosin does not affect PSA levels & must be taken indefinitely to maintain its therapeutic effect. Off-label: Randomized trials indicate that tamsulosin can increase the rate of passage of kidney stones by 49% more than placebo (76% passage on tamsulosin, 48% passage on placebo) (Hollingsworth et al 2016).
Is titration necessary for tamsulosin?
Dosage titration at the start of treatment is not necessary. Tamsulo sin has a rapid onset of action and is effective in patients with moderate or severe symptoms. The drug is therefore a valuable therapeutic option, with both demonstrated and potential advantages over older nonselective agents, in the management of patients with LUTS associated ...
Is tamsulosin an alpha receptor?
Abstract. Tamsulosin is a subtype-selective alpha (1A)- and alpha (1D )-adrenoceptor antagonist. alpha (1)-Receptors predominate in the prostate gland, prostatic capsule, prostatic urethra and bladder, and the relaxation of prostate and bladder smooth muscles is associated with improved maximal urine flow (Q ...
Does tamsulosin affect blood pressure?
Tamsulosin has not been associated with clinically significant changes in blood pressure in clinical trials. Conclusion: The alpha (1A)- and alpha (1D)-adrenoceptor antagonist tamsulosin, given at a dosage of 0.4 mg once daily in a modified-release formulation, is effective and well tolerated in the treatment of LUTS associated with BPH.
Does tamsulosin interfere with antihypertensive therapy?
Tamsulosin is effective in patients with mild to severe LUTS associated with BPH, in patients with diabetes mellitus and in the elderly, and does not interfere with concomitant antihypertensive therapy.
What are the side effects of tamsulosin?
Common tamsulosin side effects may include: low blood pressure;
What is flomax used for?
Tamsulosin (Flomax) is an alpha-blocker that relaxes the muscles in the prostate and bladder neck, making it easier to urinate. Tamsulosin is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate). Tamsulosin is not FDA approved for use in women or children.
Can tamsulosin cause hives?
Tamsulosin side effects. Get emergency medical help if you have signs of an allergic reaction to tamsulosin: hives, rash, itching; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: a light-headed feeling, like you might pass out;
Is tamsulosin safe for eyes?
To make sure tamsulosin is safe for you, tell your doctor if you have: liver or kidney disease; a history of prostate cancer; low blood pressure; or. an allergy to sulfa drugs. Tamsulosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medicine.
Can tamsulosin be used before cataract surgery?
Tamsulosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using tamsulosin before surgery unless your surgeon tells you to. There are many other drugs that can interact with this medicine.
Can you stop tamsulosin before surgery?
Do not stop using tamsulosin before surgery unless your surgeon tells you to. Although this medicine is not for use in women, tamsulosin is not expected to harm an unborn baby. If you are a woman using this medication, tell your doctor if you are pregnant or breast-feeding.
Can alcohol cause tamsulosin to be overheated?
To prevent dizziness, avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Drinking alcohol can increase certain side effects of tamsulosin.
How to take missed Tamsulosin?
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. If treatment with Tamsulosin is missed for several days, contact doctor before restarting the medication and a lower dose may be necessary to restart the drug.
How long after a meal should I take 400mg of a sulfate supplement?
Adult: 400mg / day drug to be taken 30 minutes after the same meal each day and if sufficient response does not obtained then increase the dose to 800mg / day after 2 or 4 weeks.#N#Children: Not recommended
Does 4-azasteroid inhibit 5alpha reductase?
This synthetic 4-azasteroid derivative competitively inhibits steroid 5alpha reductase, which is an enzyme responsible for active androgen dehydrotestosterone (this enzyme influences the development of prostate gland, so decreasing level of this hormone relieve the symptoms associated with benign prostatic hyperplasia)from testosterone.
What is the mechanism of action of tamsulosin?
Mechanism of Action: Tamsulosin is a selective antagonist at alpha-1-receptors. Alpha-1-receptors are involved in contraction of smooth muscle and are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck. Three subtypes of alpha-1-receptors have been identified: Alpha-1a, alpha-1b, and alpha-1d. Alpha-1a receptors mediate human prostatic smooth muscle contraction whereas alpha-1b and alpha-1d-receptors are involved in vascular smooth muscle contraction. Both alpha-1a and alpha-1b-receptors exist in the prostate, however, approximately 70% of the alpha-receptors in the human prostate are of the alpha-1a subtype. Tamsulosin has 7—38-fold greater affinity for alpha-1a-receptors than for alpha-1b-receptors. Blockade of these receptors by tamsulosin can cause smooth muscles in the bladder neck and prostate to relax, thereby improving urine flow rate and reducing symptoms of BPH.
How long does tamsulosin stay in your system?
Adults with radiopaque lower ureteral stones of 10 mm or smaller have received tamsulosin 0.4 mg PO at bedtime for 28 days or until definite stone passage (i.e., evidence of stone on urine straining) in addition to standard analgesia (e.g., NSAID, etc.) in clinical studies. Data suggest that patients receiving tamsulosin for medical expulsive therapy (MET) with stones of 5 to 10 mm pass the stones earlier and with less pain than if no tamsulosin is received; thus, MET may be considered in these patients. Tamsulosin may offer little benefit over placebo for patients with stones of less than 5 mm.
Can tamsulosin cause floppy iris?
Patients receiving or who have previously received treatment with tamsulosin or other alpha-1 blockers may be at risk for intraoperative floppy iris syndrome (IFIS) during surgery for cataracts (ocular surgery). Intraoperative floppy iris syndrome is a small pupil syndrome variant that is characterized by a flaccid iris that billows in response to intraoperative irrigation currents, progressive intraoperative miosis despite preoperative dilation with standard mydriatic drugs, and potential prolapse of the iris toward the phacoemulsification incisions. IFIS may increase the risk of eye complications during and after surgery. Ophthalmologists should be prepared for possible modifications to their surgical technique such as the use of iris hooks, iris dilator rings, or viscoelastic substances. The benefit of stopping alpha-1 blocker therapy prior to cataract surgery has not been established. However, it is recommended to avoid initiation of new therapy with tamsulosin in patients scheduled for cataract surgery.
Is tamsulosin FDA approved?
Tamsulosin is only FDA-approved to treat benign prostatic hyperplasia in men; the drug is not FDA-approved for use in children. There are limited clinical data regarding use in pediatric patients for off-label purposes; use with caution. There are no data describing tamsulosin use in infants.
Is tamsulosin safe for breast feeding?
Tamsulosin is not indicated in women, and there are no data on the use of tamsulosin in breast-feeding women. There are no data regarding the presence or absence of tamsulosin in human milk, the effects of tamsulosin on the breastfed infant, or the effects on milk production. [29677]
Is tamsulosin safe for hepatic impairment?
Tamsulosin has not been studied in patients with severe hepatic impairment. Since tamsulosin is extensively metabolized, cautious dosage initiation at a lower dosage is prudent in patients with severe hepatic disease.
Can tamsulosin cause syncope?
Tamsulosin should be used cautiously in patients with orthostatic hypotension, vertigo, or syncope. The signs and symptoms of orthostasis (postural hypotension, dizziness, and vertigo) were more frequently reported in tamsulosin-treated patients than those receiving placebo. As with other alpha-adrenergic blocking agents, there is a potential risk of syncope and patients should be cautioned to avoid situations where injury could result should syncope occur. Elderly patients and patients with renal impairment or renal failure should be monitored carefully for exaggerated hypotensive effects (e.g., first dose effect).
Overview
Mechanism
Tamsulosin is a selective α1 receptor antagonist that has preferential selectivity for the α1A receptor in the prostate versus the α1B receptor in the blood vessels.
When alpha 1 receptors in the bladder neck, the prostate, the ureter, and the urethra are blocked, a relaxation in smooth muscle tissue results. This mechanism decreases resistance to urinary flow, reduces discomfort associated with BPH, and facilitates passage of kidney stones.
Medical uses
Tamsulosin is primarily used for benign prostatic hyperplasia and to help with the passage of kidney stones. Tamsulosin, however, appears to be effective only for stones over 4 mm and less than 10 mm in size.
Tamsulosin is also used as an add-on treatment for acute urinary retention. People may void more successfully after catheter removal if they are taking ta…
Adverse effects
• Eyes: People taking tamsulosin are prone to a complication known as floppy iris syndrome during cataract surgery. Adverse outcomes of the surgery are greatly reduced by the surgeon's prior knowledge of the person's history with this drug, and thus having the option of alternative techniques.
• Severe hypotension.
Brand names
Tamsulosin was first marketed in 1996 under the trade name Flomax. The U.S. patent expired in October 2009. The U.S. Food and Drug Administration (FDA) approved generics in March 2010. In 2010, tamsulosin was available as OTC medication in UK.
It is marketed by various companies under licence, including Boehringer Ingelheim and CSL. Tamsulosin hydrochloride extended-release capsules are marketed under the trade names Urim…
External links
• "Tamsulosin". Drug Information Portal. U.S. National Library of Medicine.
• "Tamsulosin hydrochloride". Drug Information Portal. U.S. National Library of Medicine.