What is SWISS-MODEL used for?
SWISS-MODEL (http://swissmodel.expasy.org) is a server for automated comparative modeling of three-dimensional (3D) protein structures. It pioneered the field of automated modeling starting in 1993 and is the most widely-used free web-based automated modeling facility today.
How accurate is SWISS-MODEL?
SWISS-MODEL is a structural bioinformatics web-server dedicated to homology modeling of 3D protein structures. Homology modeling is currently the most accurate method to generate reliable three-dimensional protein structure models and is routinely used in many practical applications.
What is Qmean SWISS-MODEL?
QMEAN is a composite scoring function which is able to derive both global (i.e. for the entire structure) and local (i.e. per residue) absolute quality estimates on the basis of one single model. There are two global score values, QMEAN4 and QMEAN6. QMEAN4 is a linear combination of four statistical potential terms.
How do you make a model for a SWISS-MODEL?
How build a model using the DeepView Project ModeGet the template in the correct quaternary state. First, check the correct biological assembly of your template protein. ... Remove all non-amino acid residues. ... Ensure unique chain IDs. ... Target sequence. ... Adjust target–template alignment in DeepView. ... SWISS-MODEL submission.
What is Z score in SWISS-MODEL?
In SWISS-MODEL the QMEAN z-score represents an estimate of how comparable the model is to experimentally derived structures of similar size. QMEAN z-scores around zero indicate good agreement between the model structure and experimental structures of similar size.
What is QSQE in SWISS-MODEL?
The QSQE score is a number between 0 and 1, reflecting the expected accuracy of the interchain contacts for a model built based a given alignment and template. In general a higher QSQE is "better", while a value above 0.7 can be considered reliable to follow the predicted quaternary structure in the modelling process.
How does homology Modelling work?
Homology modeling relies on the identification of one or more known protein structures likely to resemble the structure of the query sequence, and on the production of an alignment that maps residues in the query sequence to residues in the template sequence.
What is Rmsd in protein structures?
Root mean square deviation (RMSD) is used for measuring the difference between the backbones of a protein from its initial structural conformation to its final position. The stability of the protein relative to its conformation can be determined by the deviations produced during the course of its simulation.
How do you use Swiss Prot?
SWISS-PROT provides detailed annotation information on protein sequences. Annotation include information on protein function, post-translational modification of proteins, domains and binding sites, secondary structures, quaternary structures, and diseases associated with protein deficiency.
Why is the Swiss cheese model useful?
Kamoun and Nicho found the Swiss cheese model to be a useful theoretical model to explain the multifaceted (human, organizational and technological) aspects of healthcare data breaches.
What is the Swiss cheese model of accident causation?
The Swiss cheese model of accident causation is a model used in risk analysis and risk management, including aviation safety, engineering, ...
Who proposed the lapses and weaknesses model?
The model was originally formally propounded by James T. Reason of the University of Manchester, and has since gained widespread acceptance.
SWISS-MODEL
is a fully automated protein structure homology-modelling server, accessible via the Expasy web server, or from the program DeepView (Swiss Pdb-Viewer).
Repository
Every week we model all the sequences for thirteen core species based on the latest UniProtKB proteome. Is your protein already modelled and up to date in SWISS-MODEL Repository ?
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2, is a positive-sense, single-stranded RNA coronavirus. It is a contagious virus that causes coronavirus disease 2019 (COVID-19).
History
Production of the show was officially announced in September 2017. Host and judges were announced in April 2018.
Format
Coming from the same production company, both in general look and concept the show takes a lot of inspiration from Germany's Next Top Model.
What is Swiss system?
The Swiss system is used for competitions in which there are too many entrants for a full round-robin (all-play-all) to be feasible, and eliminating any competitors before the end of the tournament is undesirable.
When was the Swiss system invented?
The system was first employed at a chess tournament in Zurich in 1895 , hence the name "Swiss system", and is now used in many games including chess, go, bridge and Scrabble .
What is the Swiss ladder system in badminton?
International Student Badminton Tournaments depend on the Swiss ladder system to ensure its players get as many challenging matches as possible over the course of the badminton tournament. The tournaments are meant to promote both the sport and the social aspect of the game, hence its results are not connected to external rankings. Beforehand, players can enroll in three or four categories designed to separate national, regional and recreational players. Players of different clubs are coupled to form doubles and mixed doubles. The starting positions on each ladder (singles, doubles and mixed doubles) are random. Unlike in official matches a 1–1 draw is possible and games are usually not extended after 21 is reached in order to maximise the number of played matches.
What is the advantage of Swiss system?
Compared to a knockout tournament, a Swiss system has the advantage of not eliminating anyone ; a player who enters the tournament knows that they can play in all the rounds, regardless of results. The only exception is that one player is left over when there is an odd number of players.
What is Swiss system tournament?
A Swiss-system tournament is a non-eliminating tournament format that features a fixed number of rounds of competition, but considerably fewer than for a round-robin tournament; thus each competitor (team or individual) does not play all the other competitors. Competitors meet one-on-one in each round ...
Do you need to record the waves in a Swiss tournament?
In a Swiss tournament, all the results of a particular round need to be recorded before the next round may begin .
Do all teams play in a Swiss curling tournament?
In a true Swiss tournament all teams play in one group. However, in a curling arena there are a limited number of curling sheets available at any one time. Therefore, the teams are usually divided into groups, and the groups are rearranged after a round or two. The criteria used for ranking are, in order:
What was the economy of Switzerland in the 1990s?
Switzerland's economy was marred by slow growth in the 1990s, having the weakest economic growth in Western Europe. The economy was affected by a three-year recession from 1991 to 1993, when the economy contracted by 2%. The contraction also became apparent in Switzerland's energy consumption and export growth rates.
What was the energy consumption of Switzerland in 1950?
In the 1950s, annual GDP growth averaged 5% and Switzerland's energy consumption nearly doubled. Coal lost its rank as Switzerland's primary energy source, as other imported fossil fuels, such as crude and refined oil and natural and refined gas, increased.
What is Switzerland's largest trading partner?
Switzerland's largest trading partner is Germany. In 2017, 17% of Switzerland's exports and 20% of its imports came from Germany. The United States was the second largest destination of exports (10% of total exports) and the second largest source of imports (7.8%).
What are the major industries in Switzerland?
Most noticeably, food processing like Nestlé, machines and robot manufacturers such as ABB, Bobst SA and Stadler Rail, chemicals for industrial and construction use like Sika AG, or military equipment such as Ruag .
What was the unemployment rate in Switzerland in 1997?
After enjoying unemployment rates lower than 1% before 1990, the three-year recession also caused the unemployment rate to rise to its all-time peak of 5.3% in 1997.
How much did Switzerland export in 2011?
The CIA World Factbook estimates Switzerland's 2011 exports at $308.3 billion and the 2010 exports at $258.5 billion. Imports are estimated to be $299.6 billion in 2011 and $246.2 billion in 2010. According to the World Factbook numbers, Switzerland is the 20th largest exporter and the 18th largest importer.
What were the economic factors of Switzerland?
Both tourism and banking began to develop as economic factors at about the same time. While Switzerland was primarily rural, the cities experienced an industrial revolution in the late 19th century, focused especially on textiles. In Basel, for example, textiles, including silk, were the leading industry.
When was Swiss Reinsurance founded?
The Swiss Reinsurance Company of Zurich was founded on 19 December 1863 by the Helvetia General Insurance Company (now known as Helvetia Versicherungen) in St. Gallen, the Schweizerische Kreditanstalt ( Credit Suisse) in Zurich and the Basler Handelsbank (predecessor of UBS AG) in Basel. The company's articles of association were approved by ...
When did Swiss Re buy Life Assurance?
The UK Admin Re business of Swiss Re began with the acquisition on 1 July 2004 of Life Assurance Holding Corporation.
How much did Warren Buffett invest in Swiss Re?
In 2009, Warren Buffett invested $2.6 billion as a part of Swiss Re's raising equity capital Berkshire Hathaway already owns a 3% stake, with rights to own more than 20%.
Where are Swiss Re offices?
In Europe, the Middle East and Africa ( EMEA ), Swiss Re has offices in Denmark, France, Germany, Italy, Luxembourg, Netherlands, Slovakia, Spain, Switzerland, Israel, South Africa, United Arab Emirates and the United Kingdom. In Asia and Australasia, the group has offices in the following countries: Australia, China, Hong Kong, India, Japan, Malaysia, Singapore, South Korea. There are also offices in the Americas: in Barbados, Brazil, Canada, Mexico and the United States.
Who was the first secretary of the Canton of Zurich?
The official foundation document bore the signature of the poet Gottfried Keller, who at the time was first secretary of the Canton of Zurich. Swiss Re was the lead insurer of the World Trade Center during the September 11 attacks which led to an insurance dispute with the owner, Silverstein Properties.
Overview
The Swiss cheese model of accident causation is a model used in risk analysis and risk management, including aviation safety, engineering, healthcare, emergency service organizations, and as the principle behind layered security, as used in computer security and defense in depth. It likens human systems to multiple slices of Swiss cheese, stacked side by side, in which the risk of a thre…
Holes and slices
In the Swiss cheese model, an organisation's defenses against failure are modeled as a series of imperfect barriers, represented as slices of cheese, specifically Swiss cheese with holes known as "eyes", such as Emmental cheese. The holes in the slices represent weaknesses in individual parts of the system and are continually varying in size and position across the slices. The system …
Active and latent failures
The model includes active and Passive failures. Active failures encompass the unsafe acts that can be directly linked to an accident, such as (in the case of aircraft accidents) a navigation error. Latent failures include contributory factors that may lie dormant for days, weeks, or months until they contribute to the accident. Latent failures span the first three domains of failure in Reason's model.
Applications
The same framework can be applicable in some areas of healthcare. For example, a latent failure could be the similar packaging of two drugs that are then stored close to each other in a pharmacy. Such a failure would be a contributory factor in the administration of the wrong drug to a patient. Such research led to the realization that medical error can be the result of "system flaws, not character flaws", and that greed, ignorance, malice or laziness are not the only causes of error.
See also
• Chain of events (accident analysis)
• Healthcare error proliferation model
• Iteration
• Latent human error