Sterile Water for Injection is indicated for use only as a solvent or diluent vehicle for parenterally administered drugs or solutions and as a source of water for parenteral fluid replenishment after suitable additives are introduced.
Can you inject sterile water?
Sterile water for injection is not used directly in a person or animal. It is used to reconstitute some powdered medications (antibiotics, sedatives, vaccines) so they can be injected into the patient. Some medications will be altered and made ineffective if sterile saline, lactated ringers solution, or dextrose are used to reconstitute them.
Where to buy sterile water?
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How to make sterile water and sterile saline #861?
What is Sterile Irrigation Water?
- Clinical Pharmacology. Sterile irrigation water performs cleansing actions of the body cavities, tissues, surgical drainage tubes, and indwelling urethral catheters.
- Indication and Usage. Sterile irrigation water is used for general irrigation, rinsing, washing, and dilution purposes.
- Contraindication. ...
Can you drink water for injection?
Drinking Water for Injection or Other Pharmaceutical Grade Water. Is water for injection (WFI) water is drinkable? Yes you can drink WFI but it is a very huge waste of money to do so unless there is a specific need for it. Under normal conditions you would not drink it because of the expense to produce it.
What is sterile water for injection used for?
Sterile water for injection vials are primarily used to reconstitute medications available as lyophilized powders. While the prescribing information for some medications may indicate alternative sterile liquids for reconstitution, most specify that SW for injection must be used.
What happens if you inject sterile water?
Sterile water is hypotonic (0 mOsm/L). Serious patient harm, including hemolysis, can result when it is administered by direct IV infusion. PA-PSRS and other medication error reporting programs have received reports of IV administration of sterile water to patients, some of which have resulted in patient deaths.
What is sterile water used for in pharmacy?
Sterile Water for injections: Packaged and rendered sterile used for reconstitution of dry powder injections.
Can you inject someone with sterile water?
Sterile water for injection is 0 mOsm/L, which can be fatal. It should never be given intravenously to patients.
Does sterile water expire?
Sterile Water for Injection is given an expiration date by the FDA based on how long the product is expected to maintain sterility (“shelf life”). After the expiration date, the vacuum may no longer be working, and bacteria may get in to contaminate the water.
How long is sterile water good for?
A container label that states “single dose container” on any bottle of sterile irrigation fluids indicates that once opened, any unused fluid must be immediately discarded.
What is the difference between sterile water for injection and water for injection?
Water for injection is water of extra high quality without significant contamination. A sterile version is used for making solutions that will be given by injection. Before such use other substances generally must be added to make the solution more or less isotonic.
What is the difference between sterile water and distilled water?
Sterile water is water free from organic materials but is still not free from inorganic chemicals. Distilled water has some sterilization process but removes both organic and inorganic contaminants in the water. Thus, distilled water gives a pure form of water.
Is sterile water the same as saline?
Conclusion: Sterile water is an inexpensive alternative to isotonic saline for irrigation during PCNL. We did not find any difference between the two irrigation solutions regarding the safety; however, this should be confirmed further, especially for larger calculi.
How much sterile water should you inject?
Sterile Water for Injection - Clinical Pharmacology Average normal adult daily requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production).
Can you inject water into your bloodstream?
False. Use a sterile liquid: water or saline. Both tap and toilet water are not safe to inject into your blood.
Do sterile water injections hurt?
The injections cause a brief but intense stinging sensation, like a wasp sting, that lasts for about 30 seconds and then wears off completely. As the stinging sensation eases, relief from the back pain is felt.
What would happen if you were given pure water in an IV?
So, pure water injected into an IV would diffuse via osmosis into the more concentrated environment inside red blood cells, make them swell up because of the excess water and eventually make them burst. To avoid this, IV solutions are almost always saline solutions, essentially solutions of salt and water.
What is the difference between water for injection and sterile water for injection?
Water for injection is water of extra high quality without significant contamination. A sterile version is used for making solutions that will be given by injection. Before such use other substances generally must be added to make the solution more or less isotonic.
What happens if you drink sterile water?
Due to the hypotonicity, absorption of Sterile Water for Irrigation can result in serious adverse reactions of hyponatremia, hypoosmolality and fluid overload, resulting in fatality or permanent morbidity. Complications include cerebral edema , encephalopathy, pulmonary edema, massive hemolysis, rhabdomyolysis, renal failure, and hyperkalemia [see ADVERSE REACTIONS ]. In addition, excessive volume or pressure of the irrigation fluid may also cause undue distension of body cavities and may cause tissue disruption (e.g., tears or perforation). These complications can manifest after irrigation has ended and immediate intervention may be required.
What is the pH of sterile water for irrigation?
No antimicrobial agent or other substance has been added. The pH is 5.5 (5.0 to 7.0). Sterile Water for Irrigation is hypotonic with an osmolarity of zero mOsmol/L.
What to check before adding a substance?
Before adding a substance or medication, verify that it is soluble and/or stable in water and that the pH range of Sterile Water for Irrigation is appropriate.
What are the adverse reactions of water for irrigation?
Other Adverse reactions which may occur in association with absorption of water for irrigation include: Blood and Lymphatic System Disorders: Hemolysis (hemoglobinemia, hemoglobinuria) Metabolism and Nutrition Disorders: Hypervolemia, hypoosmolality, hyperkalemia, acid/base balance disorder.
Is sterile water safe for irrigation?
Appropriate administration of Sterile Water for Irrigation is not expected to cause adverse developmental outcomes. There are no available data on Sterile Water for Irrigation use in pregnant women to determine a drug-associated risk of adverse developmental outcomes. Animal reproduction studies have not been conducted with Sterile Water for Irrigation.
Is sterile water hypotonic?
Sterile Water for Irrigation is hypotonic with an osmolarity of zero mOsmol/L. It is intended for use as irrigation fluid and not for intravenous administration or administration by other, usual parenteral routes, such as intravascular administration in general, subcutaneous administration, or intramuscular administration.
Is sterile water conductive?
In contrast to other irrigation fluids containing electrolytes, Sterile Water for Irrigation is non-conductive. Therefore, when choosing the distension solution/fluid used with electrosurgery or cautery, ensure compatibility with the equipment.
What is sterile water used for?
Sterile Water for Injection is indicated for use only as a solvent or diluent vehicle for parenterally administered drugs or solutions and as a source of water for parenteral fluid replenishment after suitable additives are introduced.
What is the osmolarity of sterile water for injection?
When administered intravenously as a vehicle for drugs, sterile Water for Injection provides a source of water for parenteral fluid replenishment after sufficient solute is introduced to achieve an osmolarity of 112 mOsmol or more per liter.
What is USP sterile water?
Sterile Water for Injection, USP is a sterile, nonpyrogenic, solute-free preparation of distilled Water for Injection. It is for use only as a sterile solvent or diluent vehicle for drugs or solutions suitable for parenteral administration. The pH is 5.5 (5.0 to 7.0).
How is water balance maintained?
Water balance is maintained by various regulatory mechanisms. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na +) plays a major role in maintaining physiologic equilibrium.
How much water is needed to maintain a healthy body?
Average normal adult daily requirement ranges from two to three liters ( 1.0 to 1.5 liters each for insensible water loss by perspiration and urine production). Water balance is maintained by various regulatory mechanisms.
Can sterile water cause fetal harm?
Pregnancy Category C. Animal reproduction studies have not been conducted with sterile Water for Injection. It is also not known whether sterile water containing additives can cause fetal harm when administer ed to a pregnant woman or can affect reproduction capacity.
Is sterile water a buffer?
Sterile Water for Injection contains no bacteriostat, antimicrobial agent or added. buffer and is intended only for single dose injection after admixture with an appropriate solute or solution. When smaller amounts are required, the unused portion should be discarded. Sterile Water for Injection is a pharmaceutic aid (vehicle) ...
INDICATIONS AND USAGE
This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered.
sterile water for injection, USP Quick Finder
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INDICATIONS AND USAGE
This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be...
DOSAGE AND ADMINISTRATION
The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the...
CONTRAINDICATIONS
Sterile Water for Injection, USP must be made approximately isotonic prior to use.
WARNINGS
Intravenous administration of Sterile Water for Injection without a solute may result in hemolysis.
ADVERSE REACTIONS
Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the...
What is sterile water?
Sterile water simply put is purified, distilled water with no preservatives or added and no microbial growth. It is also nonpyrogenic, meaning that it won’t cause fevers when in use. The pH or acidity level of sterile water is between 5.0 to 7.0. Now that you have a clear cut definition of sterile water, let’s look at the medical uses first ...
How does a neti pot work?
The neti pot is a system in which water is inserted in one nostril via a specialized pot or bottle and flushed throughout the sinuses and out the other nostril. This method is in close proximity to the brain and major blood vessels which can pose as a huge contamination and infection point. Many patients mix the neti pot saline packets ...
Can sterile water be used in everyday life?
What can’t it be? Sterile water has a myriad of uses in medical and everyday applications. Let’s first discuss what it isn’t. Many people confuse sterile water for other potable water preparations such as bacteriostatic water, dextrose water, bottled water, and saline water. Despite sharing a few similarities, these water sources are not equivalent ...
Can sterile water be stored?
Lastly since sterile water is microbial free in nature, exposure to body, surroundings, and other factors can easily contaminate the sample. Sterile water is meant as a one time use and bottles should not be stored away once opened.
Can you drink sterile water?
In short, you can drink sterile water although it is not preferred. Not only is it costly and bland to taste, but it also has no electrolytes to truly quench your thirst. Drinking excess amounts can cause pH changes and electrolyte imbalances which lead to more serious bodily dangers.
Can you use sterile water for a solo injection?
Irrigation use of sterile water includes washing, rinsing, and dilu tion.
Can you inject sterile water alone?
Injection use includes the various degrees of penetration such as intramuscular (in the muscle), intravenous (in the veins), and subcutaneous (under the skin).It is important to note that sterile water must be mixed with another medicine and never injected alone. Solo injection use will cause hemolysis, or the breaking up of red blood cells.
What is USP sterile water?
Sterile Water for Injection, USP is sterile, nonpyrogenic, distilled water in a Pharmacy Bulk Package. A Pharmacy Bulk Package is a container of a sterile preparation for parenteral use that contains many single doses. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion. No antimicrobial or other substance has been added. pH 5.5 (5.0 to 7.0). Osmolarity O mOsmol/L (calc.).
What is USP water?
Sterile Water for Injection, USP, is sterile, nonpyrogenic, distilled water in a single dose container for intravenous administration after addition of a suitable solute. It may also be used as a dispensing container for diluent use. No antimicrobial or other substance has been added. The pH is 5.5 (5.0 to 7.0). The osmolarity is 0.
Can you use plastic containers in series?
Warning: Do not use plastic containers in series connections. Such use could result in air embolism due to residual air being drawn from the primary container before administration of the fluid from the secondary container is completed.
DESCRIPTION
This preparation is designed solely for parenteral use only after addition of drugs that require dilution or must be dissolved in an aqueous vehicle prior to injection.
INDICATIONS AND USAGE
This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be...
DOSAGE AND ADMINISTRATION
The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the...
CONTRAINDICATIONS
Sterile Water for Injection, USP must be made approximately isotonic prior to use.
WARNINGS
Intravenous administration of Sterile Water for Injection without a solute may result in hemolysis.
ADVERSE REACTIONS
Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the...
OVERDOSAGE
Use only as a diluent or solvent. This parenteral preparation is unlikely to pose a threat of fluid overload except possibly in neonates or very small infants. In the event these should occur, re-evaluate the...
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Where is potable water obtained?
USP WFI may be made only by distillation or reverse osmosis. Potable water is obtained primarily from municipal water systems but may also be drawn from wells, rivers, or ponds.
How much chlorine is needed for potable water?
Chlorination of potable water is an effective treatment if minimum levels of 0.2mg/liter of free chlorine are attained. Be aware however, that any carbon or charcoal filters in the system will remove this protective chlorine and thus eliminate any inhibitory effect on microbial growth after this point.
How long does WFI need to be kept at ambient temperature?
If WFI is held at ambient temperature rather than recirculation at elevated temperature, it must be dumped or diverted to non-WFI use 24 hours after being produced.
What is point of use sampling?
Because of this possibility, point-of-use sampling is indicated, that is, drawing the water sample after it has passed through the piping system. Microbial contamination of oral liquid and topical drug products continues to be a significant problem, and is usually rooted in the use of contaminated water.
Is acceptance testing required for potable water?
According to the preamble to the Current Good Manufacturing Practice regulations (CGMPs), no acceptance testing is required for potable water unless it is obtained from sources that do not control water quality to Environmental Protection Agency (EPA) standards.
Is filtration acceptable in water?
However, filtration could be acceptable, for example, when used for reducing microbial/particulate loads in potable water used as an ingredient in chemical manufacturing where water need not be sterile. Chlorination of potable water is an effective treatment if minimum levels of 0.2mg/liter of free chlorine are attained.