ondansetron odt 4 mg tablet

by Sim Nolan Published 3 years ago Updated 3 years ago

Precautions

Ondansetron may be taken up to 3 times a day for 1 to 2 days after your chemotherapy or radiation treatment is finished. If you are taking this medication on a prescribed schedule, take it regularly in order to get the most benefit from it. To help you remember, take it at the same times each day.

How often can you take ondansetron ODT?

What is Ondansetron ODT?

prevention of post-operative nausea and vomiting
prevention of radiation-induced nausea and vomiting
cancer chemotherapy-induced nausea and vomiting
prevention of cancer chemotherapy-induced nausea and vomiting
excessive vomiting in pregnancy
acute gastroenteritis-related vomiting in pediatrics

What conditions does ondansetron ODT treat?

The way you have been told to take it will depend upon the reason why you are taking it:

If you are due to have a chemotherapy or radiotherapy treatment that could cause you to feel sick, your doctor will prescribe you a dose of ondansetron to take an ...
If you are being prescribed ondansetron because you are due to have surgery, you will be given a dose to take shortly before the operation.
Ondansetron can also be given by injection. ...

Why would you take ondansetron?

Zofran ODT (ondansetron) is an antiemetic drug that helps prevent nausea and vomiting. This prescription medication dissolves on the top of your tongue and works by preventing a chemical called serotonin from reaching certain cells in the brain. Zofran ODT is available as an orally disintegrating tablet.

What is ondansetron ODT prescribed for?

What is the USP for Ondansetron?

What is Ondansetron used for?

What are the side effects of Ondansetron?

What is the primary pathway of ondansetron?

Is Ondansetron 8 mg twice daily?

Is Ondansetron a dopamine receptor antagonist?

Is Ondansetron safe for pregnancy?

See more

About this website

What is ondansetron ODT 4 mg used for?

Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

When should you take ondansetron?

Adults and children 12 years of age and older—At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days.

What is a common side effect of ondansetron?

Zofran (ondansetron) is used to relieve nausea and vomiting commonly associated with cancer treatments like chemotherapy and radiation. It can also be used to prevent and treat post-surgical nausea and vomiting. Common side effects associated with Zofran include headache, drowsiness, constipation and the chills.

Is ondansetron 4 mg a narcotic?

Is Zofran (ondansetron) a narcotic? No, Zofran (ondansetron) is not a narcotic, instead it belongs to a class of medication called 5-HT3 (serotonin) receptor antagonist.

Does ondansetron make you sleepy?

Ondansetron orally disintegrating tablet may cause drowsiness. It can also cause other side effects.

How long does it take for ondansetron to kick in?

You can take ondansetron with or without food. Ondansetron should start to work within 30 minutes to an hour. Ondansetron tablets are available in two different forms – tablets or oral disintegrating tablets (also called ODT). Tablets: swallow the tablets with a glass of water.

Can you take ondansetron on an empty stomach?

To prevent nausea after surgery, take ondansetron by mouth 1 hour before the start of surgery. This medication may be taken with or without food. However, your doctor may tell you not to eat before chemotherapy, radiation, or surgery.

What can you not take with ondansetron?

Most frequently checked interactionsAspirin Low Strength (aspirin)Benadryl (diphenhydramine)Cymbalta (duloxetine)Fish Oil (omega-3 polyunsaturated fatty acids)Flonase (fluticasone nasal)Lyrica (pregabalin)Metoprolol Succinate ER (metoprolol)Metoprolol Tartrate (metoprolol)More items...

Is ondansetron used for anxiety?

Conclusions: Ondansetron has been shown to be an effective treatment for early-onset alcoholism. Ondansetron's ability to improve symptoms of depression, anxiety, and hostility among EOA may make an additional contribution to its therapeutic effect.

Is ondansetron a pain killer?

This suggests that ondansetron can have an analgesic effect in neuropathic pain. Side effects were minor and infrequent. Implications: The selective 5HT3 receptor antagonist ondansetron, currently used as an antiemetic, may also have analgesic properties.

What is the strongest anti nausea medication?

One of the most effective anti-nausea medications is Zofran (ondansetron) which was developed to solve this problem. Zofran is available as tablets, dissolvable tablets, strips, or liquid. While it is safe for the general population, it is so effective, that it is also used in patients undergoing chemotherapy.

What else can ondansetron be used for?

This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery.

Before Taking Ondansetron

You should not use ondansetron if: 1. you are also using apomorphine (Apokyn); or 2. you are allergic to ondansetron or similar medicines (dolasetr...

How Should I Take Ondansetron?

Take ondansetron exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or sma...

What Happens If I Miss A Dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...

What Happens If I Overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include sudden loss of vision, severe constip...

What Should I Avoid While Taking Ondansetron?

Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Ondansetron Dosing Information

Usual Adult Dose of Ondansetron for Nausea/Vomiting -- Chemotherapy Induced:Oral:Highly Emetogenic Cancer Chemotherapy (HEC):-Recommended dose: 24...

What Other Drugs Will Affect Ondansetron?

Ondansetron can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, he...

Zofran ODT (Ondansetron) Oral: Uses, Side Effects, Dosages

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine.

Ondansetron (Oral Route, Oromucosal Route) Proper Use - Mayo Clinic

Proper Use. Drug information provided by: IBM Micromedex Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

What is the USP for Ondansetron?

Ondansetron Orally Disintegrating Tablets USP, 4 mg are white to off-white, round tablets debossed with ‘5’ on one side and ‘E’ on the other side with an embossed circular edge.

What is Ondansetron used for?

Ondansetron orally disintegrating tablets are indicated for the prevention of nausea and vomiting associated with: highly emetogenic cancer chemotherapy, including cisplatin greater than or equal to 50 mg/m 2. initial and repeat courses of moderately emetogenic cancer chemotherapy. radiotherapy in patients receiving either total body irradiation, ...

What are the side effects of Ondansetron?

Hypotension (and faintness) occurred in a patient that took 48 mg of ondansetron tablets. Following infusion of 32 mg over only a 4-minute period, a vasovagal episode with transient second-degree heart block was observed. In all instances, the adverse reactions resolved completely.#N#Pediatric cases consistent with serotonin syndrome have been reported after inadvertent oral overdoses of ondansetron (exceeding estimated ingestion of 5 mg per kg) in young children. Reported symptoms included somnolence, agitation, tachycardia, tachypnea, hypertension, flushing, mydriasis, diaphoresis, myoclonic movements, horizontal nystagmus, hyperreflexia, and seizure. Patients required supportive care, including intubation in some cases, with complete recovery without sequelae within 1 to 2 days.

What is the primary pathway of ondansetron?

The primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation. In vitro metabolism studies have shown that ondansetron is a substrate for human hepatic cytochrome P-450 enzymes, including CYP1A2, CYP2D6, and CYP3A4.

Is Ondansetron 8 mg twice daily?

Dosage regimens of ondansetron 8 mg twice daily and 32 mg once daily are not recommended for the prevention of nausea and vomiting associated with highly emetogenic chemotherapy [see Dosage and Administration (2.1)].

Is Ondansetron a dopamine receptor antagonist?

While its mechanism of action has not been fully characterized, ondansetron is not a dopamine-receptor antagonist. Serotonin receptors of the 5-HT 3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. It is not certain whether ondansetron’s antiemetic action is mediated centrally, peripherally, or in both sites. However, cytotoxic chemotherapy appears to be associated with release of serotonin from the enterochromaffin cells of the small intestine. In humans, urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion increases after cisplatin administration in parallel with the onset of emesis. The released serotonin may stimulate the vagal afferents through the 5-HT 3 receptors and initiate the vomiting reflex.

Is Ondansetron safe for pregnancy?

Published epidemiological studies on the association between ondansetron use and major birth defects have reported inconsistent findings and have important methodological limitations that preclude conclusions about the safety of ondansetron use in pregnancy (see Data). Available postmarketing data have not identified a drug-associated risk of miscarriage or adverse maternal outcomes. Reproductive studies in rats and rabbits did not show evidence of harm to the fetus when ondansetron was administered during organogenesis at approximately 6 and 24 times the maximum recommended human oral dose of 24 mg/day, based on body surface area, respectively (see Data).

How it works

Ondansetron belongs to a class of drugs called antiemetics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Antiemetics are drugs that reduce nausea and vomiting.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

Drugs you should not use with ondansetron

Do not take these drugs with ondansetron. Doing so can cause dangerous effects in your body. Examples of these drugs include:

Interactions that increase your risk of side effects from ondansetron

Taking ondansetron with certain medications raises your risk of side effects from ondansetron. This is because the amount of ondansetron in your body may be increased. Examples of these drugs include:

Interactions that can make ondansetron less effective

Taking these drugs with ondansetron can make ondansetron less effective. This is because the amount of ondansetron in your body may be decreased. Examples of these drugs include:

Allergy warning

Ondansetron can cause a severe allergic reaction. Symptoms can include:

Warnings for people with certain health conditions

For people with risk factors for heart arrhythmias: If you have conditions such as heart failure or congenital long QT syndrome, this drug may increase your risk of arrhythmias. Ask your doctor if you have risk factors for arrhythmias.

How to take Ondansetron?

Take the ondansetron regular tablet with a full glass of water. To take the orally disintegrating tablet (Zofran ODT): Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.

What are the symptoms of Ondansetron?

Get emergency medical help if you have signs of an allergic reaction to ondansetron: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe constipation, stomach pain, or bloating;

How much IV nausea is recommended for a 12 year old?

Parenteral:#N#1 month to 12 years:#N#Less than 40 kg:#N#-Recommended dose: 0.1 mg/kg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)#N#40 kg and greater:#N#-Recommended dose: 4 mg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)#N#Use:#N#-Prevention of postoperative nausea and vomiting

What are the side effects of Ondansetron?

Common ondansetron side effects may include: diarrhea or constipation; headache; drowsiness; or. tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Can Ondansetron cause heart problems?

Ondansetron can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS.

Can Ondansetron harm a baby?

Ondansetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant. It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Ondansetron is not approved for use by anyone younger than 4 years old.

Is Ondansetron safe for you?

you are allergic to ondansetron or similar medicines (dolasetron, granisetron, palonosetron). To make sure ondansetron is safe for you, tell your doctor if you have: an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); a blockage in your digestive tract (stomach or intestines).

HIGHLIGHTS OF PRESCRIBING INFORMATION

These highlights do not include all the information needed to use ONDANSETRON ORALLY DISINTEGRATING TABLETS, safely and effectively. See full prescribing information for ONDANSETRON ORALLY DISINTEGRATING TABLETS. ONDANSETRON orally disintegrating tablets Initial U.S. Approval: 1991

1 INDICATIONS & USAGE

Ondansetron orally disintegrating tablets are indicated for the prevention of nausea and vomiting associated with:

3 DOSAGE FORMS & STRENGTHS

Ondansetron Orally Disintegrating Tablets USP, 4 mg are white to off-white, round tablets debossed with ‘5’ on one side and ‘E’ on the other side with an embossed circular edge.

4 CONTRAINDICATIONS

Ondansetron orally disintegrating tablets are contraindicated in patients:

8 USE IN SPECIFIC POPULATIONS

Risk Summary Available data do not reliably inform the association of ondansetron and adverse fetal outcomes. Published epidemiological studies on the association between ondansetron and fetal outcomes have reported inconsistent findings and have important methodological limitations hindering interpretation (see Data).

9 DRUG ABUSE AND DEPENDENCE

Animal studies have shown that ondansetron is not discriminated as a benzodiazepine nor does it substitute for benzodiazepines in direct addiction studies.

10 OVERDOSAGE

There is no specific antidote for ondansetron overdose. Patients should be managed with appropriate supportive therapy.

1. Indications and Usage Section

Ondansetron orally disintegrating tablets are indicated for the prevention of nausea and vomiting associated with:

2. Dosage and Administration Section

The recommended dosage regimens for adult and pediatric patients are described in Table 1 and Table 2, respectively. Corresponding doses of ondansetron tablets, ondansetron orally disintegrating tablets and ondansetron oral solution may be used interchangeably.

3. Dosage Forms and Strengths

Ondansetron Orally Disintegrating Tablets USP, 4 mg are white to off-white, round tablets debossed with ‘5’ on one side and ‘E’ on the other side with an embossed circular edge.

4. Contraindications

Ondansetron orally disintegrating tablets are contraindicated in patients:

6. Adverse Reactions

The following clinically significant adverse reactions are described elsewhere in the labeling:

7. Drug Interactions

Serotonin syndrome (including altered mental status, autonomic instability, and neuromuscular symptoms) has been described following the concomitant use of 5-HT3 receptor antagonists and other serotonergic drugs, including SSRIs and SNRIs. Monitor for the emergence of serotonin syndrome.

8. Use in Specific Populations

What to know before taking Ondansetron?

Before using ondansetron, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems ( heart failure, slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems ( QT prolongation in the EKG, sudden cardiac death).

Can Ondansetron cause allergic reactions?

Precautions. Before taking ondansetron, tell your doctor or pharmacist if you are allergic to it; or to other anti- nausea serotonin blockers (e.g., granisetron ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

Can Ondansetron make you dizzy?

Talk to your doctor about using ondansetron safely. This drug may make you dizzy or drowsy. Alcohol or marijuana ( cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages.

Can Ondansetron cause heart problems?

Ondansetron may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

What is Ondansetron dissolved in?

Ondansetron belongs to a class of medications called 5-HT3 blockers. HOW TO USE: This medication is dissolved on top of the tongue. It is not meant to be chewed or swallowed like other tablet forms. Dry your hands before using this medication. This medication may come in a bottle or a blister pack.

What to know before taking Ondansetron?

Before using ondansetron, tell your doctor or pharmacist if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

How long before radiation can you take Ondansetron?

To prevent nausea from radiation treatment, take this medication 1 to 2 hours before the start of your treatment. To prevent nausea after surgery, take ondansetron 1 hour before the start of surgery.

What is the generic name for Zofran?

COMMON BRAND NAME (S): Zofran ODT. USES: This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery.

Can you take Ondansetron if you are allergic to it?

PRECAUTIONS: Before taking ondansetron, tell your doctor or pharmacist if you are allergic to it; or to other 5-HT3 blockers (e.g., granisetron); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

What Is Zofran ODT?

What Is Zofran ODT Used For?

The Food and Drug Administration (FDA) has approved Zofran ODT to prevent: 1

What Are the Side Effects of Zofran ODT?

This is not a complete list of side effects, and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Dosage: How Much Zofran ODT Should I Take?

Overdose: What Happens If I Take Too Much Zofran ODT?

Cases of accidental Zofran overdose in children have been reported. Their symptoms were consistent with serotonin syndrome.

Precautions

Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.

What Other Medications Interact With Zofran ODT?

When taken with Zofran ODT, several medications may increase your risk of developing serotonin syndrome. Along with Zofran ODT, if you are taking a medicine that increases serotonin levels in the body, your doctor may need to choose a different treatment or monitor you more closely.

What is the USP for Ondansetron?

Ondansetron Orally Disintegrating Tablets USP, 4 mg are white to off-white, round tablets debossed with ‘5’ on one side and ‘E’ on the other side with an embossed circular edge.