Precautions
The way you have been told to take it will depend upon the reason why you are taking it:
- If you are due to have a chemotherapy or radiotherapy treatment that could cause you to feel sick, your doctor will prescribe you a dose of ondansetron to take an ...
- If you are being prescribed ondansetron because you are due to have surgery, you will be given a dose to take shortly before the operation.
- Ondansetron can also be given by injection. ...
Why would you take ondansetron?
Ultimately, this determination is made by the DEA. The DEA has a drug scheduling and controlled substances list that are the veritable “who’s who” of dangerous (and potentially dangerous) drugs. Promethazine is absent from both of these lists which has allowed this medication to experience signficantly lower levels of restrictions.
Is Phenergan DM a controlled substance?
Promethazine with Codeine Oral Solution contains codeine, a Schedule V controlled substance. As an opioid, Promethazine with Codeine Oral Solution exposes users to the risks of addiction, abuse, and misuse [see Drug Abuse and Dependence ( 9)], which can lead to overdose and death [see Overdosage ( 10)]. Reserve Promethazine with Codeine Oral Solution for use in adult patients for whom the benefits of cough suppression are expected to outweigh the risks, and in whom an adequate assessment of ...
Is Phenergan with codeine a controlled substance?
Risperidone is an antipsychotic medicine that works by changing the effects of chemicals in the brain. Risperidone is used to treat schizophrenia in adults and children who are at least 13 years old. Risperidone is also used to treat symptoms of bipolar disorder (manic depression) in adults and children who are at least 10 years old.
Is resperidol a controlled substance?
Is there a difference between Zofran and ondansetron?
What is Zofran? Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Zofran is available in generic form.
What class of drug is ondansetron?
5-HT3 antagonistOndansetron / ClassificationThe 5-HT₃ antagonists, informally known as "setrons", are a class of drugs that act as receptor antagonists at the 5-HT₃ receptor, a subtype of serotonin receptor found in terminals of the vagus nerve and in certain areas of the brain. Wikipedia
Is Zofran considered a drug?
This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.
Is ondansetron a hazardous drug?
Material Name: Ondansetron Hydrochloride Injection (Hospira, Inc.) Signal Word: Not Classified Hazard Statements: Non-hazardous in accordance with international standards for workplace safety.
Why is ondansetron not over the counter?
Ondansetron is a prescription medication, which means you can't get it over the counter. It must be prescribed by a healthcare professional.
Is ondansetron used for anxiety?
Conclusions: Ondansetron has been shown to be an effective treatment for early-onset alcoholism. Ondansetron's ability to improve symptoms of depression, anxiety, and hostility among EOA may make an additional contribution to its therapeutic effect.
Why was Zofran taken off the market?
FDA Drug Safety Communications & Zofran Recall In 2012, the 32 mg intravenous dose of Zofran was pulled from the market due to concerns that it could trigger QT interval prolongation, a heart rhythm disorder that could lead to an abnormal and potentially fatal heart rhythm called Torsades de Pointes.
What is the strongest anti nausea medication?
One of the most effective anti-nausea medications is Zofran (ondansetron) which was developed to solve this problem. Zofran is available as tablets, dissolvable tablets, strips, or liquid. While it is safe for the general population, it is so effective, that it is also used in patients undergoing chemotherapy.
Does ondansetron make you sleepy?
Ondansetron orally disintegrating tablet may cause drowsiness. It can also cause other side effects.
How much ondansetron is fatal?
16 Overdose is rare and no fatal dose has been established. The largest single dose reported was 145 mg (1.5 mg/kg).
What can you not take with ondansetron?
Some products that may interact with this drug are: apomorphine, tramadol. Many drugs besides ondansetron may affect the heart rhythm (QT prolongation), including dofetilide, pimozide, procainamide, amiodarone, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others.
What is the antidote for ondansetron?
There is no specific antidote for ondansetron overdose. Patients should be managed with appropriate supportive therapy.
What is the drug Zofran (ondansetron) used for?
Zofran (ondansetron) is a medication used to prevent nausea and vomiting caused by cancer medications (chemotherapy), radiation therapy, and surger...
Does Zofran (ondansetron) make you sleepy?
Zofran (ondansetron) may cause sleepiness and/or make you feel tired. Therefore, you should avoid driving or operating heavy machinery until you kn...
Is Zofran (ondansetron) a narcotic?
No, Zofran (ondansetron) is not a narcotic, instead it belongs to a class of medication called 5-HT3 (serotonin) receptor antagonist.
Can you still throw up after taking Zofran (ondansetron)?
Yes, you can still vomit after taking Zofran (ondansetron). Zofran (ondansetron) is used for the prevention of nausea and vomiting. If you're activ...
How quickly does Zofran (ondansetron) work?
Zofran (ondansetron) should work pretty quickly. Many people report relief within about 30 minutes and it reaches maximum blood concentrations in a...
What is Zuplenz and is it still available on the market?
Zuplenz (ondansetron) is a brand of ondansetron that comes as an oral film that dissolves on the tongue in 4 to 20 seconds. Zuplenz (ondansetron) i...
Where is Ondansetron located?
The 5-HT 3 receptors are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema in the medulla.
Why is Ondansetron not easy to detect?
In addition, the authors found the covert duplication of reports on ondansetron was not easy to detect, because of lack of cross-referencing between papers, and reports containing duplicate findings were cited in eight reviews of the drug.
What is the name of the medication that is given to people who are vomiting?
Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It is also effective for treating gastroenteritis. It is ineffective for treating vomiting caused by motion sickness. It can be given by mouth or by injection into a muscle or into a vein.
What is the best medicine for nausea?
Ondansetron. Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It is also effective for treating gastroenteritis. It is ineffective for treating vomiting caused by motion sickness.
When was Zofran developed?
A vial of Zofran 4 mg containing ondansetron for intravenous injection. Ondansetron (marketed under the brand name Zofran) was developed in the mid-1980s by GlaxoSmithKline in London. It was granted US patent protection in September 1987, received a use patent June 1988, and was approved by the US FDA in January 1991.
How many people received Ondansetron?
In 1997, ondansetron was the subject of a meta-analysis case study published in the British Medical Journal. Researchers examined 84 trials, with 11,980 people receiving ondansetron, published between 1991 and September 1996.
When was Ondansetron first used?
Ondansetron was patented in 1984 and approved for medical use in 1990. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2018, it was the 64th most commonly prescribed medication in the United States, with more than 12 million prescriptions.
What is Zofran used for?
Zofran (ondansetron) is used to prevent nausea and vomiting caused by cancer medications (chemotherapy), radiation therapy, or surgery. It's available in different forms which can be helpful if you're unable to swallow or keep things down.
How does Zofran work?
Zofran (ondansetron) is an antiemetic that works by blocking the actions of serotonin in the body that can trigger nausea and vomiting.
How long does Zofran last?
The effects of Zofran (ondansetron) can last anywhere between 8 to 12 hours.
What is the ingredient in Zofran?
Risk factors: People who have phenylketonuria (a disorder that makes people unable to break down and get rid of phenylalanine) The dissolvable tablet of Zofran (ondansetron) contains an ingredient called phenylalanine.
Can Zofran be used for nausea?
Can be used in both adults and children. Unlike some other nausea medications, the side effects for Zofran (ondansetron) are relatively mild. Available as a lower-cost generic.
Is Zofran a narcotic?
No, Zofran (ondansetron) is not a narcotic, instead it belongs to a class of medication called 5-HT3 (serotonin) receptor antagonist.
What to do if someone collapses after taking Ondansetron?
If someone collapses or isn't breathing after taking ondansetron, call 911 immediately .
What is Zofran ODT?
Zofran ODT (ondansetron) is an antiemetic drug that helps prevent nausea and vomiting. This prescription medication dissolves on the top of your tongue and works by preventing a chemical called serotonin from reaching certain cells in the brain.
What to do if you miss Zofran?
In that case, skip your missed dose and take your Zofran ODT at your regularly scheduled time.
How to store Zofran ODT?
Store the Zofran ODT bottle or foil blister pack at room temperature or in the refrigerator. Be sure to keep your medication out of reach of children and pets.
What is the name of the drug that is similar to Zofran?
Two drugs that most closely resemble Zofran ODT are Anzemet (dolasetron) and the generic drug granisetron (the brand-name Kytril has been discontinued in the United States). These drugs also work by blocking the effects of serotonin in the body. 6
How long does it take for Zofran to work?
Zofran begins to work within 30 minutes of taking it and reaches peak blood levels within one to two hours. 2
How to report a drug side effect?
If you experience a serious side effect, you or your provider may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting Program or by phone (1-800-332-1088) .
What is Ondansetron used for?
Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists.
Is Zofran a controlled substance?
Zofran 8 mg is not a controlled substance under the Controlled Substances Act (CSA).
What is a controlled substance analogue?
A controlled substance analogue is a substance which is intended for human consumption, is structurally substantially similar to a schedule I or schedule II substance, is pharmacologically substantially similar to a schedule I or schedule II substance, or is represented as being similar to a schedule I or schedule II substance and is not an approved medication in the United States. See 21 U.S.C. §802 (32) (A) for the definition of a controlled substance analogue and 21 U.S.C. §813 for the schedule.
What are the other Schedule II substances?
Other Schedule II substances include: amobarbital, glutethimide, and pentobarbital.
How many schedules are there for drugs?
Drugs and other substances that are considered controlled substances under the Controlled Substances Act (CSA) are divided into five schedules. An updated and complete list of the schedules is published annually in Title 21 Code of Federal Regulations (C.F.R.) §§1308.11 through 1308.15. Substances are placed in their respective schedules based on whether they have a currently accepted medical use in treatment in the United States, their relative abuse potential, and likelihood of causing dependence when abused. Some examples of the drugs in each schedule are listed below.
Why are controlled substances considered controlled substances?
Controlled substances are drugs that are subject to strict government control because they may cause addiction or be misused.
What is the purpose of the Controlled Substances Act?
The purpose of the controlled substances act is to enhance controlled substance regulation. To this end, distributors, manufacturers, ...
How many categories of controlled substances are there?
Controlled substances are grouped into five categories (also known as schedules) depending on their medical uses and ability to lead to abuse or dependency. 3
What are some examples of Schedule 1 drugs?
Some examples of schedule 1 drugs include LSD, heroin, peyote, marijuana, and methaqualone.
Overview
This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery.
May Treat: Cancer chemotherapy-induced nausea and vomiting · Chemotherapy-induced nausea and vomiting · Post-operative nausea and vomiting · Radiation-induced nausea and vomiting
Brand Names: Zofran ODT · Zuplenz
Drug Class: Antiemetic - Selective Serotonin 5-HT3 Antagonists
Availability: Prescription Required
Pregnancy: Consult a doctor before using
May Treat: Cancer chemotherapy-induced nausea and vomiting · Chemotherapy-induced nausea and vomiting · Post-operative nausea and vomiting · Radiation-induced nausea and vomiting
Brand Names: Zofran ODT · Zuplenz
Drug Class: Antiemetic - Selective Serotonin 5-HT3 Antagonists
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
Driving: May cause drowsiness or dizziness. Use caution
- Call Dr before increasing dose or frequency.
- May make you drowsy or dizzy. Drive with caution
- Tell doctor if fainting or faintness occurs.
- Call Dr before increasing dose or frequency.
- May make you drowsy or dizzy. Drive with caution
- Tell doctor if fainting or faintness occurs.
- Call doctor if you are not getting better
- Be careful not to stand up too quickly
- For film, medicated products : If available, read the patient package insert. Dry hands before using. Dissolve on tongue. Do not chew or swallow whole.
- For tablet, disintegrating products : Before using tell Dr. if you have phenylketonuria. Open with dry hands and place tablet on tongue. Caution. Follow directions on best place to keep drug supply.
Research
Medical uses
Special populations
Adverse effects
Pharmacodynamics
A 2006 double-blind, randomized controlled trial indicated ondansetron may have value in the treatment of schizophrenia, as an adjunct to haloperidol. The study found the combination to significantly improve negative schizophrenia symptoms, and people taking both drugs experienced fewer of the adverse effects commonly associated with haloperidol. An earlier, smaller, open-label trial had found ondansetron to be useful in treating antipsychotic-induced tardive dyskinesia in pe…
History
Although an effective antiemetic agent, the high cost of brand-name ondansetron initially limited its use to controlling postoperative nausea and vomiting and chemotherapy-induced nausea and vomiting.
The 5-HT3 receptor antagonists are the primary medications used to treat and prevent chemotherapy-induced nausea and vomiting and radiotherapy-induced nausea and vomiting.
Society and culture
Ondansetron has rarely been studied in people under 4 years of age. As such, little data is available to guide dosage recommendations.
It is not necessary to adjust the dosage for people under 75 years of age. The use of ondansetron has not been studied in people older than 75 years of age, and it is not known if dosage should be adjusted for this group.