The sedative can cause total respiratory failure in humans. Women and asthmatics should avoid Lutalyse, a prostaglandin
Prostaglandin
The prostaglandins are a group of physiologically active lipid compounds called eicosanoids having diverse hormone-like effects in animals. Prostaglandins have been found in almost every tissue in humans and other animals. They are derived enzymatically from the fatty acid arachid…
What will Lutalyse do to humans?
Also, what will Lutalyse do to humans? The sedative can cause total respiratory failure in humans. Women and asthmatics should avoid Lutalyse, a prostaglandin used to induce abortions and calving in cows. It can also cause abortion or spontaneous labour in pregnant women or bronchospasms in asthmatics.
Is Lutalyse safe for pregnant women?
Women and asthmatics should avoid Lutalyse, a prostaglandin used to induce abortions and calving in cows. It can also cause abortion or spontaneous labour in pregnant women or bronchospasms in asthmatics. Furthermore, is Estrumate the same as Lutalyse?
Is Lutalyse legal in the US?
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. LUTALYSE® Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt.
What are the animal safety warnings for Lutalyse?
Animal Safety Warnings: Severe localized clostridial infections associated with injection of LUTALYSE have been reported. In rare instances, such infections have resulted in death. Aggressive antibiotic therapy should be employed at the first sign of infection at the injection site whether localized or diffuse.
What happens if a human takes Lutalyse?
Inhalation may cause difficulty breathing, chest tightness, and respiratory irritation with coughing, wheezing, and sputum generation. May cause eye irritation. Exposure may cause temporary irritation, redness, or discomfort. Prolonged skin contact may cause temporary irritation.
How much Lutalyse do humans need?
Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2 mL LUTALYSE Injection. This luteolytic effect can be utilized to control the timing of estrus in estrous cycling and clinically anestrous mares that have a corpus luteum in the following circumstances: 1.
Where do you inject Lutalyse?
LUTALYSE HighCon Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) intramuscularly or subcutaneously either once or twice at a 10 to 12 day interval.
Is Lutalyse given IM?
LUTALYSE HighCon is the first and only prostaglandin approved by the Food and Drug Administration (FDA) for subcutaneous (SC) administration in addition to intramuscular (IM) administration.
How long does Lutalyse take to work?
An injection of Lutalyse causes the corpus luteum to regress earlier than normal. This elimi- nates the source of progesterone. Usually, in 2 to 5 days after receiving Lutalyse, the female comes into heat and is ready for breeding.
How fast does Lutalyse work?
With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present.
How long does Lutalyse last?
of 2 mL LUTALYSE (10 mg dinoprost) to parturition of approximately 30 hours. This can be employed to control the time of farrowing in sows and gilts in late gestation. specific location, and (2) the breeding and projected farrowing dates for each animal.
How long is Lutalyse good for?
Are there any changes for the care and handling of LUTALYSE HighCon bottles? The bottle contents should be used within 12 weeks of first vial puncture. Note that the stopper may be punctured a maximum of 20 times.
Is Lutalyse a prescription drug?
Please note that this item requires a veterinarian's prescription.
How do you inject Lutalyse?
LUTALYSE Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly either once or twice at a 10 to 12 day interval.
Can Lutalyse cause miscarriage?
Prostaglandins such as Lutalyse, Prostamate and Estrumate can lead to the abortion of a sow's pregnancy if there is an accidental exposure; they can also cause abortion in pregnant women.
How much does Lutalyse cost?
Lutalyse Catalog #DescriptionPricesc-362914Rx5mg/ml, 30 ml$21.55sc-363010Rx5mg/ml, 100 ml$57.81
What is lutalyse used for?
Lutalyse is the brand name for dinoprost tromethamine, a sterile solution used for several cattle, swine and mare birthing & birth-related medical conditions. More specifically, dinoprost is used for: estrus synchronization, as well as the treatment of unobserved (silent) estrus, and pyometra (chronic endometritis) in cattle; abortion of feedlot and other non-lactating cattle; parturition induction (induced birthing labor) in swine and; for controlling the timing of estrus in estrous cycling mares and clinically anestrous mares that have a corpus luteum.
How long does it take for Lutalyse to work?
With a fast-acting response time, Lutalyse is reported to return desired results to in as little as two weeks. However, multiple studies have been run on the human implications for this drug, many of which remain conflictingly inconclusive.
Does Lutalyse cause bronchial pain?
There are a variety of possible bronchi al and gastrointestinal conditions associated with the use of Lutalyse, but the most prominent athlete specific (those taking it for performance and physique enhancing purposes) side effects include: injection site pain; flu-like symptoms; diarrhea; abdominal/stomach pain; false sense of urgency toward enuresis (uncontrollable urination) and encopresis (uncontrollable defecation); malaise and; general bodily discomfort.
Does Lutalyse help with muscle building?
For bodybuilding/athletic purposes Lutalyse holds a dual role in that it: 1) possesses strong protein synthesis which not only greatly accelerates muscle building, but also appears to have spot/localized (specially where injected) muscle enhancing effect on both size & definition and; 2) is clinically proven to incite lipolysis (fat burning and mobilization) within fat cells.
What is a lutealyse?
LUTALYSE® Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection.
When to inject lutealyse in cows?
LUTALYSE Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Inject a dose of 25 mg dinoprost (5 mL) intramuscularly. Cattle that abort will abort within 35 days of injection.
How to treat silent estrus in cows?
2. For Unobserved (Silent) Estrus in Lactating Dairy Cows with a Corpus Luteum. Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly. Breed cows as they are detected in estrus. If estrus has not been observed by 80 hours after injection, breed at 80 hours. If the cow returns to estrus, breed at the usual time relative to estrus.
How long after luteal injection can cattle be bred?
With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present.
Is luteolytic injection effective for cattle?
Cattle - LUTALYSE Injection is indicated as a luteolytic agent. LUTALYSE Injection is effective only in those cattle having a corpus luteum, i.e., those which ovulated at least five days prior to ...
Can lutealyse be used for future reproductive performance?
Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE Injection.
Is Dinoprost safe for humans?
User Safety: Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water.
How effective is lutealyse?
LUTALYSE is effective only in those cattle having a corpus luteum , i.e., those which ovulated at least five days prior to treatment . Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE.
What is lutealyse used for?
LUTALYSE is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum.
How long does it take for a mare to ovulate after a lutealyse injection?
In one study with 122 Standardbred and Thoroughbred mares in clinical anestrus for an average of 58 days and treated during the breeding season, behavioral estrus was detected in 81 percent at an average time of 3.7 days after injection with 5 mg LUTALYSE; ovulation occurred an average of 7.0 days after treatment. Of those mares bred, 59% were pregnant following an average of 1.4 services during that estrus.
How early can you administer lutealyse?
The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). It is important that adequate records be maintained on (1) the average length of gestation period for the animals on a specific location, and (2) the breeding and projected farrowing dates for each animal. This information is essential to determine the appropriate time for administration of LUTALYSE.
When to use luteallyse solution for swine?
LUTALYSE Sterile Solution is indicated for parturition induction in swine when injected within 3 days of normal predicted farrowing.
How many times should you enter a multidose vial?
Adequately clean and disinfect the vial stopper prior to entry with a sterile needle and syringe. No vial closure should be entered more than 20 times.
Is lutealyse safe for animals?
Animal Safety Warnings: Severe localized clostridial infections associated with injection of LUTALYSE have been reported. In rare instances, such infections have resulted in death. Aggressive antibiotic therapy should be employed at the first sign of infection at the injection site whether localized or diffuse.
How to use lutealyse injection?
LUTALYSE Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly either once or twice at a 10 to 12 day interval. With the single injection, cattle should be bred at the usual time relative to estrus. With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days.
When to inject lutealyse in cows?
LUTALYSE Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Inject a dose of 25 mg dinoprost (5 mL) intramuscularly. Cattle that abort will abort within 35 days of injection.
How much luteolytic injection is given to a mare?
Mares: LUTALYSE Injection is indicated for its luteolytic effect in mares. Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2 mL LUTALYSE Injection. This luteolytic effect can be utilized to control the timing of estrus in estrous cycling and clinically anestrous mares that have a corpus luteum in the following circumstances:
How long after luteal injection can cattle be bred?
With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present.
How early can you administer lumalyse injection?
The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). It is important that adequate records be maintained on (1) the average length of gestation period for the animals on a specific location, and (2) the breeding and projected farrowing dates for each animal. This information is essential to determine the appropriate time for administration of LUTALYSE Injection.
How many times can you use a vial stopper?
Use only sterile needles, and use each needle only once. No vial stopper should be entered more than 20 times . For this reason, the 100 mL bottle should only be used for cattle. The 30 mL bottle may be used for cattle, swine, or mares.
Is luteolytic injection effective for cattle?
Cattle: LUTALYSE Injection is indicated as a luteolytic agent. LUTALYSE Injection is effective only in those cattle having a corpus luteum, i.e., those which ovulated at least five days prior to treatment.
How much IM is needed for pyometra?
For postpartum treatment of pyometra, inject a dose of 5 mL IM at signs of pyometra (presence of a corpus luteum on the ovary and uterine horns containing fluid but not a conceptus based on palpation).
What is Zoetis dairy?
Zoetis is the world leader in dairy reproduction research and support and its products are supported by industry-leading sales and technical services.
Is lutealyse safe for pregnant women?
Aseptic technique should be used to reduce the possibility of post-injection clostridial infections. Do not administer LUTALYSE in pregnant cattle unless cessation of pregnancy is desired. See full Prescribing Information.