Receiving Helpdesk

is lurasidone a controlled substance

by Ronny Hagenes II Published 2 years ago Updated 2 years ago

No, Latuda (generic name: lurasidone) is not classified as a controlled substance by the U.S. Drug Enforcement Agency (DEA). Latuda is an atypical antipsychotic approved for patients with schizophrenia or bipolar depression. None of the atypical antipsychotics in the U.S. are classified as a controlled substance.Jul 20, 2020

Precautions

Last updated on July 20, 2020. No, Latuda (generic name: lurasidone) is not classified as a controlled substance by the U.S. Drug Enforcement Agency (DEA). Latuda is an atypical antipsychotic approved for patients with schizophrenia or bipolar depression.

Is Latuda (lurasidone) a controlled substance?

Lurasidone is used to treat symptoms of psychotic (mental) disorders, such as schizophrenia. Lurasidone should not be used to treat behavioral problems in elderly patients who have dementia. It may be used alone or with other medicines (eg, lithium, valproate) to treat depression caused by bipolar disorder.

What is the drug lurasidone used to treat?

Lurasidone. Common side effects include sleepiness, movement disorders, nausea, and diarrhea. Serious side effects may include the potentially permanent movement disorder tardive dyskinesia, as well as neuroleptic malignant syndrome, an increased risk of suicide, angioedema, and high blood sugar levels.

What are the side effects of lurasidone?

In 2019 generic versions were approved in the United States but will not be available until 2023. [10] [11] In 2019, it was the 220th most commonly prescribed medication in the United States, with more than 2 million prescriptions. [12] [13] Lurasidone is used for the treatment of schizophrenia and bipolar disorder. [2]

Is there a generic version of lurasidone in the US?

What type of drug is lurasidone?

Lurasidone is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.

What category is Latuda in?

Lurasidone HCl (Latuda, Sunovion), an atypical antipsychotic tablet, belongs to the chemical class of benzoisothiazol derivatives and is indicated for the treatment of patients with schizophrenia.

Is Latuda addictive?

LATUDA belongs to a group of medicines called atypical antipsychotics. It helps to correct chemical imbalances in the brain, which may cause mental illness. There is no evidence that LATUDA is addictive or habit forming. This medicine is available only with a doctor's prescription.

Is antipsychotic a controlled drug?

Since antipsychotics are not classified as controlled substances, the majority of clinicians may not consider the diversion of antipsychotics for recreational purposes, but evidence of this is increasing, particularly in incarcerated individuals.

Is lurasidone a sedating?

Somnolence/sedation is associated with many antipsychotic treatments, and lurasidone is less sedating than other atypical antipsychotics, such as quetiapine, olanzapine and risperidone [7], even at a high dose level.

Does Latuda give you energy?

Overview. Latuda (lurasidone) is an antipsychotic medication used to treat schizophrenia in adults. It may help promote clear thinking, reduce nervousness, decrease hallucinations, as well as improve mood, sleep, appetite, and energy level.

Which is better Seroquel or Latuda?

Many evaluate different parameter types. A twelve-month, double-blind study compared Latuda and Seroquel for their efficacy in preventing relapse in schizophrenia. At the twelve-month mark, Latuda was associated with higher rates of maintained remission of schizophrenia symptoms and a reduced risk of hospitalization.

Does Latuda make you happy?

I started with 20mg and went as high as 60 mg. I am now stable with Latuda 40mg and 10mg of Prozac. I feel myself again. I know have the energy to do anything, my anxiety is gone, I can sleep, and I genuinely feel happy.

Is Latuda a mood stabilizer or antipsychotic?

Latuda (generic name: lurasidone) is an atypical antipsychotic approved for treatment of patients with either schizophrenia and bipolar depression. Medicines classified as atypical antipsychotics and mood stabilizers are standard treatments for patients with schizophrenia or bipolar disorder.

What is considered a controlled substance?

A drug or other substance that is tightly controlled by the government because it may be abused or cause addiction. The control applies to the way the substance is made, used, handled, stored, and distributed. Controlled substances include opioids, stimulants, depressants, hallucinogens, and anabolic steroids.

Does latuda help with depression?

Latuda® (lurasidone HCl) is a once-a-day prescription medicine FDA-approved to treat bipolar depression in adults and children (10 to 17 years). And, in clinical studies, LATUDA was effective for people struggling with bipolar depression.

Why is Seroquel not a controlled substance?

Seroquel is not a controlled substance, as it's believed not to cause addiction. But studies from recent years report widespread off-label use of the drug.

Does Latuda make you sleepy?

Yes, Latuda (generic name: lurasidone) can cause drowsiness and make you feel sleepy. Drowsiness (somnolence) is one of the most common side effect...

Can you stop taking Latuda immediately?

Talk to your doctor before stopping Latuda (lurasidone) or adjusting your dose, even if you feel better after starting treatment. If you stop takin...

Is Latuda a mood stabilizer or an antipsychotic?

Latuda (lurasidone) is classified as an atypical antipsychotic and is approved for treatment of patients with either schizophrenia and bipolar depr...

How fast does Latuda work?

Latuda works in most patients within 6 weeks or sooner at an appropriate dose, although results can vary between patients. Some patients may respon...

Does Latuda cause weight gain?

Latuda has a low risk for weight gain in adults and children with schizophrenia or bipolar depression, but this can vary in individual patients. In...

Can Latuda be cut in half or split?

Latuda should NOT be cut in half or split, according to the manufacturer. It comes in various strengths to allow your doctor to prescribe the corre...

Is Latuda a controlled substance?

No, Latuda (an atypical antipsychotic) is not classified as a controlled substance by the U.S. Drug Enforcement Agency (DEA). None of the atypical...

How quickly does Latuda (lurasidone) work?

Latuda (lurasidone) can take up to 6 weeks to work. Be patient with the medication, and continue to take it exactly as prescribed by your healthcar...

Is Latuda (lurasidone) safe to take while pregnant?

Taking Latuda (lurasidone) in the third trimester of pregnancy can be harmful to your baby. Babies may be born with movement disorders or withdrawa...

What happens if you take Latuda (lurasidone) without food?

Latuda (lurasidone) may not work as well if you take it without food. Taking it with food helps the medication get absorbed into the body better.

Who should not take Latuda (lurasidone)?

You should not take Latuda (lurasidone) if you have any allergies to the components in the formulation of the medication or if you are taking Latud...

What does Latuda (lurasidone) do for bipolar disorder?

Latuda (lurasidone) helps rebalance and adjust the serotonin and dopamine chemicals in your brain. By adjusting the levels of these natural chemica...

Does latuda help with neurotransmitter levels?

Lurasidone, the active ingredient in Latuda, may help to adjust neurotransmitter levels or their action to ease symptoms. However, the exact way that Latuda works in these conditions is not fully known.

Is Latuda a monotherapy?

Latuda is also approved for the treatment of bipolar depression (major depressive episode associated with bipolar I disorder) as a single treatment (monotherapy) in adults and children 10 to 17 years of age.

Is Latuda an antidepressant?

Latuda is not classified as an antidepressant. It is part of a group of medicines called atypical antipsychotics. Atypical antipsychotics are thought to work by adjusting levels of various chemical messengers in the brain called neurotransmitters. Neurotransmitters allow communication between nerve cells in the brain.

Does Latuda cause drug seeking?

However, clinical studies conducted by the manufacturer for Latuda approval did not reveal any tendency for Latuda to cause drug- seeking behavior in patients. Some treatments that work in the brain may be linked with abuse after FDA approval in certain patients, and it is difficult to always predict these effects.

Is Latuda a controlled substance?

Bottom Line. Latuda is not classified as a controlled substance. It is an atypical antipsychotic used in the treatment of bipolar disorder and schizophrenia. Some drugs can be linked with drug abuse after FDA-approval, even though they are not predicted to be abused or do not have properties that lends themselves to drug abuse.

When was Lurasidone approved?

Regulatory approval. Lurasidone was approved in the United States for the treatment of schizophrenia in October 2010 and for the treatment of depressive episodes associated with bipolar I disorder in June 2013. It received regulatory approval in the United Kingdom in September 2014.

What is lurasidone used for?

Lurasidone, sold under the trade name Latuda among others, is an antipsychotic medication used to treat schizophrenia and bipolar disorder. In bipolar it may be used together with a mood stabilizer such as lithium or valproate. It is taken by mouth.

How many metabolites does lurasidone have?

Several dozen metabolites have been identified altogether. :59–61.

What receptors does Lurasidone bind to?

The smaller the value, the more strongly the drug binds to the site. Lurasidone acts as an antagonist of the dopamine D 2 and D 3 receptors, the serotonin 5-HT 2A and 5-HT 7 receptors, and the α 2C -adrenergic receptor, and as a partial agonist of the serotonin 5-HT 1A receptor.

How much does lurasidone absorb?

Lurasidone is taken by mouth and has an estimated absorption rate of 9 to 19%. Studies have shown that when lurasidone is taken with food, absorption increases about twofold. Peak blood plasma concentrations are reached after one to three hours. About 99% of the circulating substance are bound to plasma proteins.

Is Lurasidone effective for schizophrenia?

A 2013 review of 15 antipsychotic medications in schizophrenia found lurasidone demonstrated mild effectiveness. It is considered to be as effective as iloperidone , and 13 to 15% less effective than ziprasidone, chlorpromazine, and asenapine. In July 2013, lurasidone received approval for bipolar I depression.

Is ziprasidone a structural analogue?

Lurasidone is a structural analogue of ziprasidone. Lurasidone shows a very close pharmacological profile and has been synthesized similarly to ziprasidone. Lurasidone is chemically similar to perospirone (also a chemical analogue of ziprasidone), as well as risperidone, paliperidone and iloperidone.

What receptors does Lurasidone bind to?

Lurasidone is an antagonist with high affinity binding at the dopamine D 2 receptors (Ki of 1 nM) and the serotonin 5-HT 2A (Ki of 0.5 nM) and 5-HT 7 (Ki of 0.5 nM) receptors . It also binds with moderate affinity to the human α 2C adrenergic receptors (Ki of 11 nM), is a partial agonist at serotonin 5-HT 1A (Ki of 6.4 nM) receptors, and is an antagonist at the α 2A adrenergic receptors (Ki of 41 nM). Lurasidone exhibits little or no affinity for histamine H 1 and muscarinic M 1 receptors (IC 50 > 1,000 nM).

How much lurasidone is in a daily dose?

The pharmacokinetics of lurasidone hydrochloride is dose-proportional within a total daily dose range of 20 mg to 160 mg. Steady-state concentrations of lurasidone hydrochloride are reached within 7 days of starting lurasidone hydrochloride.

How much lurasidone is used for bipolar?

The following findings are based on two adult short-term, placebo-controlled premarketing studies for bipolar depression in which lurasidone hydrochloride was administered at daily doses ranging from 20 to 120 mg as adjunctive therapy with lithium or valproate (n=360).

How long does it take to increase lurasidone?

Initial dose titration is not required. The dose may be increased after one week based on clinical response. Lurasidone hydrochloride tablet has been shown to be effective in a dose range of 20 mg per day to 80 mg per day as monotherapy.

Is lurasidone in human milk?

Lactation studies have not been conducted to assess the presence of lurasidone in human milk, the effects on the breastfed infant, or the effects on milk production. Lurasidone is present in rat milk. The development and health benefits of breastfeeding should be considered along with the mother’s clinical need for lurasidone hydrochloride and any potential adverse effects on the breastfed infant from lurasidone hydrochloride or from the underlying maternal condition.

Does lurasidone affect motor skills?

Lurasidone hydrochloride, like other antipsychotics, has the potential to impair judgment, thinking or motor skills. Caution patients about operating hazardous machinery, including motor vehicles, until they are reasonably certain that therapy with lurasidone hydrochloride does not affect them adversely.

Can lurasidone be used for dementia?

As with other antipsychotic drugs, lurasidone hydrochloride should be used cautiously in patients with a history of seizures or with conditions that lower the seizure threshold, e.g., Alzheimer’s dementia. Conditions that lower the seizure threshold may be more prevalent in patients 65 years or older.

What is lurasidone used for?

Lurasidone is used to treat symptoms of psychotic (mental) disorders, such as schizophrenia. This medicine should not be used to treat behavioral problems in elderly patients who have dementia. It may be used alone or with other medicines (eg, lithium, valproate) to treat depression caused by bipolar disorder.

What is the lowest price for Latuda?

It is used to treat schizophrenia or bipolar disorder, also known as manic-depression. The lowest GoodRx price for the most common version of Latuda is around $1,316.15, 21% off the average retail price of $1,681.72. Compare atypical antipsychotics.

Is Lurasidone approved for dementia?

Blackbox Warning TOP. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Lurasidone is not approved for the treatment of patients with dementia-related psychosis.

What is lurasidone used for?

Lurasidone is also used along with lithium (Lithobid) or valproate (Depacon) to treat depression in adults with bipolar disorder. Lurasidone is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.

What is the phone number to call for poison control?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Does lurasidone make you drowsy?

you should know that lurasidone may make you drowsy. Do not drive a car or operate hazardous machinery until you know how this medication affects you. you should know that you may experience hyperglycemia (increases in your blood sugar) while you are taking this medication, even if you do not already have diabetes.

Does lurasidone cause shaking?

anxiety. weakness. tiredness. restlessness. uncontrollable shaking of a part of the body. slow movements or shuffling walk.

Can you take lurasidone more often?

Do not take more or less of it or take it more often than prescribed by your doctor. Lurasidone controls schizophrenia and depression in people with bipolar disorder but it does not cure these conditions. It may take several weeks or longer before you feel the full benefit of lurasidone.

Can you call the doctor for lurasidone?

Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking lurasidone, especially at the beginning of your treatment.

Can lurasidone cause shortness of breath?

shortness of breath. abnormal heartbeat. sore throat, fever, cough, chills, and other signs of infection. fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness. unusual movements of your face or body that you cannot control. falling. Lurasidone may cause other side effects.

What is lurasidone used for?

Lurasidone is used to treat symptoms of psychotic (mental) disorders, such as schizophrenia. Lurasidone should not be used to treat behavioral problems in elderly patients who have dementia. It may be used alone or with other medicines (eg, lithium, valproate) to treat depression caused by bipolar disorder.

What to do if you miss a dose of Lurasidone?

If you miss a dose of lurasidone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Can you take lurasidone more than once a day?

Take lurasidone only as directed by your doctor even if you feel well. Do not take more of lurasidone and do not take it more often than your doctor ordered. Lurasidone works best if there is a constant amount in the blood. To keep blood levels constant, take lurasidone at the same time each day and do not miss any doses.

Can lurasidone be used for dementia?

However, lurasidone should not be used for behavioral problems in older adults with dementia.

Is Lurasidone safe for dementia patients?

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Lurasidone is not approved for the treatment of patients with dementia-related psychosis. An increased risk of suicidal thoughts and behavior was found in pediatric and young adult patients taking antidepressants. Monitor for clinical worsening and emergence of suicidal thoughts and behaviors .

Can you change the dose of lurasidone?

The following information includes only the average doses of lurasidone. If your dose is different, do not change it unless your doctor tells you to do so.

Usual Adult Dose for Schizophrenia

Initial dose: 40 mg orally once a day Maintenance dose: 40 to 160 mg orally per day Maximum dose: 160 mg/day Comments: -Initial dose titration is not needed. -This drug should be taken with food (at least 350 calories); drug exposure is expected to be significantly lower if not taken with food. Use: For the treatment of schizophrenia

Usual Adult Dose for Bipolar Disorder

Initial dose: 20 mg orally once a day Maintenance dose: 20 mg to 120 mg orally once a day Maximum dose: 120 mg/day Comments: -Initial dose titration is not needed; this drug should be taken with food (at least 350 calories) drug exposure is expected to be significantly lower if not taken with food. -Initial and maintenance doses are the same for monotherapy and for adjunctive therapy; in monotherapy studies, efficacy in the lower dose range of 20 to 60 mg per day was, on average, comparable to higher doses of 80 mg to 120 mg. -The efficacy in the treatment of mania associated with bipolar disorder has not been established. Uses: -Monotherapy treatment of patients with major depressive episodes associated with bipolar I disorder (bipolar depression) -Adjunctive treatment with lithium or valproate in patients with major depressive episodes associated with bipolar I disorder (bipolar depression).

Usual Pediatric Dose for Bipolar Disorder

10 to 17 years: Initial dose: 20 mg orally once a day Maintenance dose: 20 mg to 80 mg orally once a day Maximum dose: 80 mg/day Comments: -Initial dose titration is not needed; this drug should be taken with food (at least 350 calories) drug exposure is expected to be significantly lower if not taken with food. -The dose may be increased after 1 week based on clinical response. -In monotherapy studies, efficacy in the lower dose range of 20 to 40 mg per day were, on average, comparable to doses up to 80 mg. -The efficacy in the treatment of mania associated with bipolar disorder has not been established. Use: Monotherapy treatment of patients with major depressive episodes associated with bipolar I disorder (bipolar depression).

Usual Pediatric Dose for Schizophrenia

13 to 17 years: Initial dose: 40 mg orally once a day Maintenance dose: 40 to 80 mg orally per day Maximum dose: 80 mg/day Comments: -Initial dose titration is not needed. -This drug should be taken with food (at least 350 calories); drug exposure is expected to be significantly lower if not taken with food. Use: For the treatment of schizophrenia

Renal Dose Adjustments

Mild Renal Dysfunction (CrCl 50 mL/min or greater): No adjustment recommended. Moderate to Severe Renal Dysfunction (CrCl less than 50 mL/min): -Initial dose 20 mg orally once a day -Maximum dose: 80 mg/day

Liver Dose Adjustments

Mild Liver Dysfunction (Child-Pugh less than 7): No adjustment recommended. Moderate Liver Dysfunction (Child-Pugh Score 7 to 9): -Initial dose 20 mg orally once a day -Maximum dose: 80 mg/day Severe Liver Dysfunction (Child-Pugh Score 10 to 15): -Initial dose 20 mg orally once a day -Maximum dose: 40 mg/day

Dose Adjustments

Patients who are antipsychotic naive and patients with a history of cardiovascular or cerebrovascular disease: Consider a lower starting dose and a slower titration due to risk of orthostatic hypotension and syncope. Concomitant Use with CYP450 3A4 Inhibitors: -Use with strong inhibitors is contraindicated. -If a moderate CYP450 3A4 inhibitor is to be added to therapy with this drug, the dose of this drug should be reduced by one-half. -If this drug is to be added to existing moderate CYP450 3A4 inhibitor therapy: ---Initial dose: 20 mg orally once a day ---Maximum dose: 80 mg/day Concomitant Use with CYP450 3A4 Inducers: -Use with strong inducers is contraindicated. -If a moderate CYP450 3A4 inducer is to be given concomitantly with this drug, the dose may need to be increased after chronic treatment of 7 or more days..

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Medical Uses

This medication is used to treat certain mental/mood disorders (such as schizophrenia, depression associated with bipolar disorder).

May Treat: Depression associated with bipolar disorder · Schizophrenia

Brand Names: Latuda

Drug Class: Antipsychotic - Atypical Dopamine-Serotonin Antag- Benzisothiazolones

Availability: Prescription Required

Pregnancy: Consult a doctor before using

May Treat: Depression associated with bipolar disorder · Schizophrenia

Brand Names: Latuda

Drug Class: Antipsychotic - Atypical Dopamine-Serotonin Antag- Benzisothiazolones

Availability: Prescription Required

Pregnancy: Consult a doctor before using

Lactation: Consult a doctor before using

Alcohol: Limit intake while taking this medication

Driving: May cause drowsiness or dizziness. Use caution

Precautions

  • Before use, important to read the Medication Guide
  • Immediately report to MD any thoughts of suicide.
  • Tell doctor your complete medical history

  • Before use, important to read the Medication Guide
  • Immediately report to MD any thoughts of suicide.
  • Tell doctor your complete medical history
  • Discuss risk vs benefits of use during pregnancy.
  • May make you drowsy or dizzy. Drive with caution
  • Avoid drinking alcohol
  • Be careful not to stand up too quickly
  • Call doctor if unusual muscle movements occur

What are side effects of Lurasidone?
Any warnings while using Lurasidone?
Does Lurasidone interact with any drugs?
Is Lurasidone contraindicated for any condition?
How to use Lurasidone?
What if you missed a dose of Lurasidone?

Contraindications

Side Effects

Interactions

Pharmacology

Image
Lurasidone is used for the treatment of schizophrenia and bipolar disorder. In the United States, lurasidone is indicated for the treatment of: 1. Schizophrenia in adults and adolescents (13 to 17 years) 2. Depressive episode associated with bipolar I disorderin adults and pediatric patients (10 to 17 years) as monotherapy …
See more on en.wikipedia.org

History

  • Lurasidone is contraindicated in individuals who are taking strong inhibitors of the liver enzyme CYP3A4 (ketoconazole, clarithromycin, ritonavir, levodropropizine, etc.) or inducers (carbamazepine, St. John's wort, phenytoin, rifampicin etc.). The use of lurasidone in pregnant women has not been studied and is not recommended; in animal studies, no risks have been fou…
See more on en.wikipedia.org

Society and Culture

  • Side effects are generally similar to other antipsychotics. The drug has a relatively well tolerated side effect profile, with low propensity for QTc interval changes, weight gain and lipid-related adverse effects. In a 2013 meta-analysis of the efficacy and tolerability of 15 antipsychotic drugs it was found to produce the second least (after haloperidol) weight gain, the least QT interval pr…
See more on en.wikipedia.org

External Links

  • Blood plasma concentrations may be increased when combined with CYP3A4 inhibitors, possibly leading to more side effects. This has been clinically verified for ketoconazole, which increases lurasidone exposure by a factor of 9, and is also expected for other 3A4 inhibitors such as grapefruit juice. Co-administration of CYP3A4 inducers like rifampicin or St. John's wort can red…
See more on en.wikipedia.org

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        bing_pop_faq_answers
        24
        bing_tab_faq_questions
        25
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        26
        google_faq_questions
        27
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        google_rich_snippet
        29
        google_search_result
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        indexedArray
        31
        total_images
        32
        total_videos
        33
        settings
        34
        url_current
        35
        menus
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        i
        38
        __currentLoopData
        39
        loop
        40
        item
      • themes.DevBlog.panels.navbar (resources/views/themes/DevBlog/panels/navbar.blade.php)41blade
        Params
        0
        __env
        1
        app
        2
        errors
        3
        post
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        postContent
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        bing_rich_snippet_text
        8
        bing_rich_snippet_link
        9
        bing_related_keywords
        10
        google_related_keywords
        11
        bing_news_title
        12
        bing_news_description
        13
        bing_videos
        14
        bing_images
        15
        bing_search_result_title
        16
        bing_search_result_description
        17
        bing_search_result_url
        18
        bing_paa_questions
        19
        bing_paa_answers
        20
        bing_slider_faq_questions
        21
        bing_slider_faq_answers
        22
        bing_pop_faq_questions
        23
        bing_pop_faq_answers
        24
        bing_tab_faq_questions
        25
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        26
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        28
        google_rich_snippet
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        google_search_result
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        indexedArray
        31
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        total_videos
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        settings
        34
        url_current
        35
        menus
        36
        sidebar
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        i
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        39
        loop
        40
        item
      • themes.DevBlog.panels.footer (resources/views/themes/DevBlog/panels/footer.blade.php)41blade
        Params
        0
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        bing_videos
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        18
        bing_paa_questions
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        20
        bing_slider_faq_questions
        21
        bing_slider_faq_answers
        22
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        23
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        24
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        25
        bing_tab_faq_answers
        26
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        27
        google_faq_answers
        28
        google_rich_snippet
        29
        google_search_result
        30
        indexedArray
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        32
        total_videos
        33
        settings
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        url_current
        35
        menus
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        sidebar
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        i
        38
        __currentLoopData
        39
        loop
        40
        item
      • themes.DevBlog.panels.scripts (resources/views/themes/DevBlog/panels/scripts.blade.php)41blade
        Params
        0
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        1
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        2
        errors
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        bing_videos
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        bing_images
        15
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        bing_search_result_description
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        bing_search_result_url
        18
        bing_paa_questions
        19
        bing_paa_answers
        20
        bing_slider_faq_questions
        21
        bing_slider_faq_answers
        22
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        23
        bing_pop_faq_answers
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        bing_tab_faq_questions
        25
        bing_tab_faq_answers
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        google_faq_questions
        27
        google_faq_answers
        28
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        menus
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        sidebar
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        i
        38
        __currentLoopData
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        40
        item
      uri
      GET {post}
      middleware
      web, checkdate
      as
      post.show
      controller
      App\Http\Controllers\Frontend\json_data\PostController@show
      namespace
      where
      file
      app/Http/Controllers/Frontend/json_data/PostController.php:18-166
      7 statements were executed403ms
      receivinghelpdeskask
      • select * from `posts` where `published_at` <= '2025-06-14 07:49:53' and `slug` = 'is-lurasidone-a-controlled-substance' and `posts`.`deleted_at` is null limit 1
        2.87ms/app/Providers/RouteServiceProvider.php:54receivinghelpdeskask
        Metadata
        Bindings
        • 0. 2025-06-14 07:49:53
        • 1. is-lurasidone-a-controlled-substance
        Backtrace
        • 15. /app/Providers/RouteServiceProvider.php:54
        • 18. /vendor/laravel/framework/src/Illuminate/Routing/Router.php:842
        • 19. Route binding:39
        • 20. /vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:167
        • 21. /vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:78
      • select * from `json_post_contents` where `json_post_contents`.`post_id` = 208938 and `json_post_contents`.`post_id` is not null and `rewrite_id` = 0
        13.1msmiddleware::checkdate:30receivinghelpdeskask
        Metadata
        Bindings
        • 0. 208938
        • 1. 0
        Backtrace
        • 19. middleware::checkdate:30
        • 20. /vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:167
        • 21. /vendor/laravel/jetstream/src/Http/Middleware/ShareInertiaData.php:61
        • 22. /vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:167
        • 23. /vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • select * from `nova_menu_menus` where `slug` = 'header' limit 1
        670μs/vendor/outl1ne/nova-menu-builder/src/helpers.php:32receivinghelpdeskask
        Metadata
        Bindings
        • 0. header
        Backtrace
        • 15. /vendor/outl1ne/nova-menu-builder/src/helpers.php:32
        • 17. /vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 18. /vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:45
        • 19. /vendor/laravel/framework/src/Illuminate/Routing/Route.php:261
        • 20. /vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
      • select * from `nova_menu_menu_items` where `nova_menu_menu_items`.`menu_id` = 1 and `nova_menu_menu_items`.`menu_id` is not null and `parent_id` is null order by `parent_id` asc, `order` asc, `name` asc
        560μs/vendor/outl1ne/nova-menu-builder/src/Models/Menu.php:35receivinghelpdeskask
        Metadata
        Bindings
        • 0. 1
        Backtrace
        • 19. /vendor/outl1ne/nova-menu-builder/src/Models/Menu.php:35
        • 20. /vendor/outl1ne/nova-menu-builder/src/helpers.php:33
        • 22. /vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 23. /vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:45
        • 24. /vendor/laravel/framework/src/Illuminate/Routing/Route.php:261
      • select * from `nova_menu_menu_items` where `nova_menu_menu_items`.`parent_id` in (1) order by `order` asc
        320μs/vendor/outl1ne/nova-menu-builder/src/Models/Menu.php:35receivinghelpdeskask
        Metadata
        Backtrace
        • 24. /vendor/outl1ne/nova-menu-builder/src/Models/Menu.php:35
        • 25. /vendor/outl1ne/nova-menu-builder/src/helpers.php:33
        • 27. /vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 28. /vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:45
        • 29. /vendor/laravel/framework/src/Illuminate/Routing/Route.php:261
      • select `id`, `post_title`, `slug` from `posts` where `status` = 'publish' and `posts`.`deleted_at` is null order by RAND() limit 10
        384ms/app/View/Composers/SidebarView.php:22receivinghelpdeskask
        Metadata
        Bindings
        • 0. publish
        Backtrace
        • 14. /app/View/Composers/SidebarView.php:22
        • 15. /app/View/Composers/SidebarView.php:12
        • 16. /vendor/laravel/framework/src/Illuminate/View/Concerns/ManagesEvents.php:124
        • 17. /vendor/laravel/framework/src/Illuminate/View/Concerns/ManagesEvents.php:162
        • 20. /vendor/laravel/framework/src/Illuminate/View/Concerns/ManagesEvents.php:177
      • select * from `fake_users` where `fake_users`.`id` = 6075 limit 1
        810μsview::2dd102cf0462e89a4d4d8bc77355d767652bf9aa:15receivinghelpdeskask
        Metadata
        Bindings
        • 0. 6075
        Backtrace
        • 21. view::2dd102cf0462e89a4d4d8bc77355d767652bf9aa:15
        • 23. /vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:108
        • 24. /vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • 25. /vendor/livewire/livewire/src/ComponentConcerns/RendersLivewireComponents.php:69
        • 26. /vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:61
      App\Models\FakeUser
      1
      Outl1ne\MenuBuilder\Models\MenuItem
      1
      Outl1ne\MenuBuilder\Models\Menu
      1
      App\Models\JsonPostContent
      1
      App\Models\Post
      11
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          array:2 [ "old" => [] "new" => [] ]
          PHPDEBUGBAR_STACK_DATA
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          status_code
          200
          status_text
          OK
          format
          html
          content_type
          text/html; charset=UTF-8
          request_query
          []
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