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how does zofran work

by Wava Stiedemann Published 3 years ago Updated 3 years ago

This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.

Precautions

What is the quickest way to get rid of a stomach bug?

  • Drink lots of fluids. Share on Pinterest.
  • Try eating the BRAT diet. Share on Pinterest.
  • Try acupressure to reduce nausea. Acupressure has been shown to be effective in treating some types of nausea.
  • Get plenty of rest.
  • Medicate with caution.

How long should Zofran take to work?

Zofran does not induce sleep; on the other hand, Phenergan induces sleep. Zofran interferes with cardiac rhythms in high doses, on the other hand, Phenergan does not interfere with cardiac rhythms Zofran can be used in patients from 6 months to onwards while Phenergan can be used in patients from 2 years to onwards.

Does Phenergan work better than Zofran?

Zofran was found to double the risk of heart defects including atrial and ventricular septal (“hole in the heart”) defects and increased the overall risk of birth defects by 30% in one study. Another study found Zofran was linked with a 237% risk of cleft palate defects.. Mothers taking Zofran during pregnancy unknowingly exposed their unborn children to birth defects.

Is Zofran bad for You?

The general, researched-baked consensus of the past was that Zofran is relatively safe in all trimesters. However, now some people suggest otherwise.

How long is it safe to use Zofran?

How long does it take for Zofran to kick in?

How quickly does Zofran (ondansetron) work? Zofran (ondansetron) should work pretty quickly. Many people report relief within about 30 minutes and it reaches maximum blood concentrations in about 2 hours. The effects of Zofran (ondansetron) can last anywhere between 8 to 12 hours.

What Zofran does to your body?

Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting. Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.25-Oct-2021

How long does it take for Zofran to kick in for nausea?

Ondansetron for nausea and vomiting sickness. Ondansetron is an anti-sickness medicine. It will start to work within 1-2 hours. The most common side-effects are a headache, constipation, and feeling flushed.14-Jan-2020

How does Zofran work for anxiety?

Ondansetron hydrochloride, the active ingredient in Zofran, belongs to a class of antiemetics (anti-nausea drugs) called 5-HT3 receptor antagonists. These drugs block serotonin, a chemical in the brain that passes signals between nerves.15-Sept-2021

Why was Zofran taken off the market?

FDA Drug Safety Communications & Zofran Recall In 2012, the 32 mg intravenous dose of Zofran was pulled from the market due to concerns that it could trigger QT interval prolongation, a heart rhythm disorder that could lead to an abnormal and potentially fatal heart rhythm called Torsades de Pointes.

Will Zofran make you sleepy?

Zofran may cause headaches, drowsiness, constipation and other mild side effects. In rare cases, the anti-nausea medication can cause erratic heartbeats and high serotonin levels, which may be life-threatening. The drug has also been said to cause birth defects, though research findings are mixed.

What if I throw up after taking Zofran?

If you vomit within one hour taking your first Zofran Tablet of each course prescribed to you, you should take the same dose again. If you continue to vomit, tell your doctor.

Will Zofran work if you swallow it?

It works by blocking one of the body's natural substances (serotonin) that causes vomiting. Ondansetron belongs to a class of medications called 5-HT3 blockers. HOW TO USE: This medication is dissolved on top of the tongue. It is not meant to be chewed or swallowed like other tablet forms.

When should you not take Zofran?

neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion. serotonin syndrome, a type of disorder with high serotonin levels. a low supply of oxygen rich blood to the heart. torsades de pointes, a type of abnormal heart rhythm.

Does Zofran relax?

Side effects of ondansetron and promethazine that are similar include drowsiness and sedation, constipation, and dizziness. Side effects of ondansetron that are different from promethazine include headache, feeling unwell (malaise), fatigue, diarrhea, and abnormal heart rate and rhythm.

Does ondansetron increase serotonin?

Thus, certain drugs and drug-drug combinations predictably induce large elevations of serotonin and therefore cause ST. Ondansetron and related compounds have been demonstrated not to possess these properties to a significant degree and are not reliably documented as causing ST.17-Oct-2014

Does Zofran help with panic attacks?

The findings suggest that oral ondansetron in doses of 0.5-2.0 mg per day is well-tolerated and may have efficacy in the treatment of panic disorder.

Before Taking This Medicine

You should not use Zofran if: 1. you are also using apomorphine (Apokyn); or 2. you are allergic to ondansetron or similar medicines (dolasetron, g...

How Should I Take Zofran?

Take Zofran exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller...

What Happens If I Miss A Dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...

What Happens If I Overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include sudden loss of vision, severe constip...

What Should I Avoid While Taking Zofran?

Zofran may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What Other Drugs Will Affect Zofran?

Zofran can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart r...

What is Zofran used for?

Zofran is a brand (trade) name for ondansetron which may be used to treat or prevent nausea and vomiting. Experts aren't sure exactly how Zofran (ondansetron) works and if its antiemetic action is mediated by a direct effect on the CTZ (the area of the brain associated with vomiting), the vagus nerve, or both.

What to do if Zofran makes you dizzy?

If Zofran makes you dizzy or drowsy, do not drive or operate machinery while affected and avoid alcohol. Tell your doctor or other health care provider about all the medicines you take, including prescription and over-the-counter (OTC) medicines, vitamins, and herbal supplements.

When to take Zofran before surgery?

When used to prevent nausea associated with surgery, Zofran is usually taken one hour before anesthesia. The dose of Zofran orally disintegrating tablets is the same as Zofran solution. When taking the orally disintegrating tablets, peel back the foil (do not attempt to push the tablet through the foil).

What medications affect serotonin?

other medications that affect serotonin, such as amphetamines, fentanyl, tramadol, triptans ( eg, almotriptan, eletriptan, or sumatriptan), or St. John's Wort . Note that this list is not all-inclusive and includes only common medications that may interact with Zofran.

Is Zofran an oral solution?

Zofran is available as tablets, orally disintegrating tablets, and an oral solution. Tablets and orally disintegrating tablets are available in 4mg and 8mg strengths. Zofran oral solution is 4mg/5mL with a strawberry odor.

Is Zofran a dopamine receptor antagonist?

Zofran is not a dopamine‑receptor antagonist. Zofran belongs to the class of medicines known as 5-HT3 receptor antagonists. 2. Upsides. Effective for the prevention of nausea and vomiting associated with cancer chemotherapy, including highly emetogenic (a high probability of causing vomiting) chemotherapy.

Can Zofran interact with Clarithromycin?

Speak to your doctor about how drug interactions should be managed. Common medications that may interact with Zofran include: antibiotics, such as clarithromycin or erythromycin.

Why is Zofran prescribed?

Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. Zofran may be used for purposes not listed in this medication guide.

What are the side effects of Zofran?

Common Zofran side effects may include: diarrhea or constipation; headache; drowsiness; or. tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Zofran side effects (more detail)

How to take Zofran ODT?

To take the orally disintegrating tablet (Zofran ODT): Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet. Use dry hands to remove the tablet and place it in your mouth.

What is Ondansetron narcotic?

a narcotic (opioid) medication; or. medicine to prevent nausea and vomiting. This list is not complete and many other drugs can interact with ondansetron. This includes prescription and over-the-counter medicines, vitamins, and herbal products.

Can Zofran harm a baby?

Zofran is not expected to harm an unborn baby. Tell your doctor if you are pregnant. It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Ondansetron is not approved for use by anyone younger than 4 years old.

Is Zofran safe for you?

you are allergic to ondansetron or similar medicines (dolasetron, granisetron, palonosetron). To make sure Zofran is safe for you, tell your doctor if you have: an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); a blockage in your digestive tract (stomach or intestines).

Can you take Zofran if you are allergic to Ondansetron?

You should not use Zofran if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Zofran orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

What Is Zofran ODT?

Zofran ODT (ondansetron) is an antiemetic drug that helps prevent nausea and vomiting. This prescription medication dissolves on the top of your tongue and works by preventing a chemical called serotonin from reaching certain cells in the brain.

What Is Zofran ODT Used For?

The Food and Drug Administration (FDA) has approved Zofran ODT to prevent: 1

What Are the Side Effects of Zofran ODT?

This is not a complete list of side effects, and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Dosage: How Much Zofran ODT Should I Take?

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

Overdose: What Happens If I Take Too Much Zofran ODT?

Cases of accidental Zofran overdose in children have been reported. Their symptoms were consistent with serotonin syndrome.

Precautions

Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.

What Other Medications Interact With Zofran ODT?

When taken with Zofran ODT, several medications may increase your risk of developing serotonin syndrome. Along with Zofran ODT, if you are taking a medicine that increases serotonin levels in the body, your doctor may need to choose a different treatment or monitor you more closely.

How to take Zofran?

How to use Zofran. To prevent nausea from chemotherapy, take this medication by mouth usually within 30 minutes before treatment begins. To prevent nausea from radiation treatment, take this medication by mouth 1 to 2 hours before the start of your treatment. To prevent nausea after surgery, take ondansetron by mouth 1 hour before the start ...

How does a syringe work?

It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.

What to know before taking Ondansetron?

Before using ondansetron, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems ( heart failure, slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems ( QT prolongation in the EKG, sudden cardiac death).

What drugs increase serotonin?

The risk of serotonin syndrome /toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including SSRIs such as fluoxetine /paroxetine, SNRIs such as duloxetine / venlafaxine ), among others.

Can drug interactions change your medication?

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.

Can Ondansetron make you dizzy?

Talk to your doctor about using ondansetron safely. This drug may make you dizzy or drowsy. Alcohol or marijuana ( cannabis) can make you more dizzy or drowsy.

How does a syringe work?

It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.

How long does it take to take Ondansetron before chemo?

To prevent nausea from chemotherapy, ondansetron is mixed in a solution and given by injection into a vein as directed by your doctor, usually over 15 minutes. This drug is usually started 30 minutes before your chemotherapy treatment begins. Do not give this medication any faster than recommended or take more than the recommended dose ...

What to know before taking Ondansetron?

Before using ondansetron, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems ( heart failure, slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems ( QT prolongation in the EKG, sudden cardiac death).

What drugs increase serotonin?

The risk of serotonin syndrome /toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including SSRIs such as fluoxetine /paroxetine, SNRIs such as duloxetine / venlafaxine ), among others.

Can you take Ondansetron after surgery?

To prevent or treat nausea after surgery, a single dose of ondansetron may be given undiluted into a muscle or vein (IV) shortly before the start of surgery, during surgery, or after surgery by a health care professional. Dosage is based on your weight, medical condition, age and response to treatment.

Can you give a vial of a syringe to yourself?

If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. When the vial is stored upright after first use, clumps may occasionally form on the top of the vial. Check the vial and the vial top carefully for particles.

Can drug interactions change your medication?

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.

Exact Answer: About 30 Minutes

Zofran is a lifesaver. It’s the only medication in existence that will make many feel better in less than two hours.

Why Would Zofran Take So Long To Work?

When people experience nausea, it’s usually in response to bodily fluid output or smelling solid odors. Additionally, it happens when the body needs energy, and the stomach gets empty. Long-term abdominal pain can also lead to weight loss and feeling nauseous.

Conclusion

It is best to avoid medication when one is pregnant. It can harm the unborn baby, and even it is not advised by breastfeeding mothers. In addition, Zofran causes sleepiness and can make one feel tired. Plus, Zofran is not a narcotic; instead, it comes under the medication – 5-HT3 receptor antagonist.

What is Ondansetron used for?

Ondansetron is a medication prescribed for the treatment and prevention of nausea and vomiting. It's a serotonin antagonist, meaning its mechanism of action is blocking the serotonin receptors in the CTZ. This reduces the communication to the vomiting center in the brain and decreases the nausea and vomiting the patient experiences.

What is the CTZ of Ondansetron?

This means these drugs block the serotonin receptors in the chemoreceptor trigger zone (CTZ) within the medulla oblongata. The CTZ communicates with the vomiting center to initiate vomiting.

How does CTZ affect vomiting?

The CTZ communicates with the vomiting center to initiate vomiting. By blocking the serotonin receptors, there's less serotonin that enters the CTZ, which decreases communication with the vomiting center. Ultimately, the patient experiences reduced nausea and vomiting.

What is the name of the drug that is used to treat nausea and vomiting?

Ondansetron. Ondansetron, commonly referred to by its brand name Zofran, is a drug that was first developed and studied in the 1980s and is now widely approved for and used in the prevention and treatment of nausea and vomiting associated with chemotherapy, radiation, and surgery. It's currently available in oral and injectable forms.

Is Ondansetron safe for pregnant women?

It should be used with caution in those who have underlying liver problems or cardiac disorders. Ondansetron has been safely used in pregnancy, as in category B, in which no adequate studies for humans have been conducted, but animal studies have shown that there is no risk to the fetus.

Is Ondansetron a pregnancy drug?

Susan is reassured when she learns that ondansetron is classified as pregnancy category B drug, meaning there are no adequate and well-controlled studies in pregnant women but animal studies have not shown a risk to the fetus.

Does Ondansetron cause dizziness?

Adverse drug reactions (ADR) for ondansetron can include headache, dizziness, constipation, and/or diarrhea. Some patients also experience drowsiness after taking ondansetron. Some medical providers feel that this side effect is not caused by the drug itself, but rather the patient is feeling better and able to rest.

How It Works

This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery.

May Treat: Cancer chemotherapy-induced nausea and vomiting · Chemotherapy-induced nausea and vomiting · Post-operative nausea and vomiting · Radiation-induced nausea and vomiting

Drug Class: Antiemetic - Selective Serotonin 5-HT3 Antagonists

Availability: Prescription Required

Pregnancy: Consult a doctor before using

Lactation: Consult a doctor before using

May Treat: Cancer chemotherapy-induced nausea and vomiting · Chemotherapy-induced nausea and vomiting · Post-operative nausea and vomiting · Radiation-induced nausea and vomiting

Drug Class: Antiemetic - Selective Serotonin 5-HT3 Antagonists

Availability: Prescription Required

Pregnancy: Consult a doctor before using

Lactation: Consult a doctor before using

Alcohol: Limit intake while taking this medication

Driving: May cause drowsiness or dizziness. Use caution

Manufacturer: GLAXOSMITHKLINE · NOVARTIS

Precautions

  • May make you drowsy or dizzy. Drive with caution
  • Be careful not to stand up too quickly
  • Tell doctor if fainting or faintness occurs.

  • May make you drowsy or dizzy. Drive with caution
  • Be careful not to stand up too quickly
  • Tell doctor if fainting or faintness occurs.
  • Call Dr before increasing dose or frequency.
  • Call doctor if you are not getting better
  • Follow directions on best place to keep drug supply
  • For solution, oral products : Measure dose using a dosing spoon/cup/syringe.
  • For tablet products : Reduce or limit drinking alcohol. Skip missed dose if almost time for next dose.
  • For vial products : Don't use if solution has particles or color change. Reduce or avoid drinking alcohol.

What are side effects of Zofran?
Any warnings while using Zofran?
Does Zofran interact with any drugs?
Is Zofran contraindicated for any condition?
How to use Zofran?
What if you missed a dose of Zofran?

Upsides

Downsides

Bottom Line

Tips

  1. Zofran is a brand (trade) name for ondansetron which may be used to treat or prevent nausea and vomiting.
  2. Experts aren't sure exactly how Zofran (ondansetron) works and if its antiemetic action is mediated by a direct effect on the CTZ (the area of the brain associated with vomiting), the vagus nerve,...
  1. Zofran is a brand (trade) name for ondansetron which may be used to treat or prevent nausea and vomiting.
  2. Experts aren't sure exactly how Zofran (ondansetron) works and if its antiemetic action is mediated by a direct effect on the CTZ (the area of the brain associated with vomiting), the vagus nerve,...
  3. Zofran belongs to the class of medicines known as 5-HT3 receptor antagonists.
See more on drugs.com

Response and Effectiveness

  1. Effective for the prevention of nausea and vomiting associated with cancer chemotherapy, including highly emetogenic (a high probability of causing vomiting) chemotherapy.
  2. May also be used to prevent nausea and vomiting associated with radiotherapy - this includes total body irradiation or single or multiple high-dose or daily fractions to the abdomen. The usual dosa...
  1. Effective for the prevention of nausea and vomiting associated with cancer chemotherapy, including highly emetogenic (a high probability of causing vomiting) chemotherapy.
  2. May also be used to prevent nausea and vomiting associated with radiotherapy - this includes total body irradiation or single or multiple high-dose or daily fractions to the abdomen. The usual dosa...
  3. Effective at preventing postoperative nausea and vomiting. The usual dosage is 16mg administered 1 hour before the induction of anesthesia.
  4. Zofran is available as tablets, orally disintegrating tablets, and an oral solution. Tablets and orally disintegrating tablets are available in 4mg and 8mg strengths. Zofran oral solution is 4mg/5m...
See more on drugs.com

Interactions

  • If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: 1. A headache, hypoxia (low oxygen), fever, dizziness, gynecological disorders, anxiety or agitation, urinary retention, and itching are the most common side effects reported. 2. Rarely may cause hiccups, flushing, blurr…
See more on drugs.com

References

  • Zofran may be used for the treatment and prevention of nausea and vomiting caused by cancer chemotherapy, radiation, or surgery. It is approved for use in adults and children over the age of 4. A h...
See more on drugs.com

Further Information

  1. Take as directed. May be taken with or without food.
  2. When used to prevent nausea associated with chemotherapy, Zofran is usually taken 30 minutes before chemotherapy. When used to prevent nausea associated with radiotherapy, Zofran is usually taken o...
  3. The dose of Zofran orally disintegrating tablets is the same as Zofran solution.
  1. Take as directed. May be taken with or without food.
  2. When used to prevent nausea associated with chemotherapy, Zofran is usually taken 30 minutes before chemotherapy. When used to prevent nausea associated with radiotherapy, Zofran is usually taken o...
  3. The dose of Zofran orally disintegrating tablets is the same as Zofran solution.
  4. When taking the orally disintegrating tablets, peel back the foil (do not attempt to push the tablet through the foil). Allow the tablet to dissolve in your mouth without chewing.
See more on drugs.com

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        4
        postContent
        5
        author
        6
        updated_at
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        bing_rich_snippet_text
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        9
        bing_related_keywords
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        google_related_keywords
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        bing_news_title
        12
        bing_news_description
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        bing_videos
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        bing_search_result_title
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        bing_search_result_description
        17
        bing_search_result_url
        18
        bing_paa_questions
        19
        bing_paa_answers
        20
        bing_slider_faq_questions
        21
        bing_slider_faq_answers
        22
        bing_pop_faq_questions
        23
        bing_pop_faq_answers
        24
        bing_tab_faq_questions
        25
        bing_tab_faq_answers
        26
        google_faq_questions
        27
        google_faq_answers
        28
        google_rich_snippet
        29
        google_search_result
        30
        indexedArray
        31
        total_images
        32
        total_videos
        33
        settings
        34
        url_current
        35
        menus
        36
        sidebar
        37
        i
        38
        __currentLoopData
        39
        loop
        40
        item
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        Params
        0
        __env
        1
        app
        2
        errors
        3
        post
        4
        postContent
        5
        author
        6
        updated_at
        7
        bing_rich_snippet_text
        8
        bing_rich_snippet_link
        9
        bing_related_keywords
        10
        google_related_keywords
        11
        bing_news_title
        12
        bing_news_description
        13
        bing_videos
        14
        bing_images
        15
        bing_search_result_title
        16
        bing_search_result_description
        17
        bing_search_result_url
        18
        bing_paa_questions
        19
        bing_paa_answers
        20
        bing_slider_faq_questions
        21
        bing_slider_faq_answers
        22
        bing_pop_faq_questions
        23
        bing_pop_faq_answers
        24
        bing_tab_faq_questions
        25
        bing_tab_faq_answers
        26
        google_faq_questions
        27
        google_faq_answers
        28
        google_rich_snippet
        29
        google_search_result
        30
        indexedArray
        31
        total_images
        32
        total_videos
        33
        settings
        34
        url_current
        35
        menus
        36
        sidebar
        37
        i
        38
        __currentLoopData
        39
        loop
        40
        item
      • themes.DevBlog.panels.footer (resources/views/themes/DevBlog/panels/footer.blade.php)41blade
        Params
        0
        __env
        1
        app
        2
        errors
        3
        post
        4
        postContent
        5
        author
        6
        updated_at
        7
        bing_rich_snippet_text
        8
        bing_rich_snippet_link
        9
        bing_related_keywords
        10
        google_related_keywords
        11
        bing_news_title
        12
        bing_news_description
        13
        bing_videos
        14
        bing_images
        15
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        16
        bing_search_result_description
        17
        bing_search_result_url
        18
        bing_paa_questions
        19
        bing_paa_answers
        20
        bing_slider_faq_questions
        21
        bing_slider_faq_answers
        22
        bing_pop_faq_questions
        23
        bing_pop_faq_answers
        24
        bing_tab_faq_questions
        25
        bing_tab_faq_answers
        26
        google_faq_questions
        27
        google_faq_answers
        28
        google_rich_snippet
        29
        google_search_result
        30
        indexedArray
        31
        total_images
        32
        total_videos
        33
        settings
        34
        url_current
        35
        menus
        36
        sidebar
        37
        i
        38
        __currentLoopData
        39
        loop
        40
        item
      • themes.DevBlog.panels.scripts (resources/views/themes/DevBlog/panels/scripts.blade.php)41blade
        Params
        0
        __env
        1
        app
        2
        errors
        3
        post
        4
        postContent
        5
        author
        6
        updated_at
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        8
        bing_rich_snippet_link
        9
        bing_related_keywords
        10
        google_related_keywords
        11
        bing_news_title
        12
        bing_news_description
        13
        bing_videos
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        bing_images
        15
        bing_search_result_title
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        bing_search_result_description
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        bing_search_result_url
        18
        bing_paa_questions
        19
        bing_paa_answers
        20
        bing_slider_faq_questions
        21
        bing_slider_faq_answers
        22
        bing_pop_faq_questions
        23
        bing_pop_faq_answers
        24
        bing_tab_faq_questions
        25
        bing_tab_faq_answers
        26
        google_faq_questions
        27
        google_faq_answers
        28
        google_rich_snippet
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        google_search_result
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      uri
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      middleware
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      as
      post.show
      controller
      App\Http\Controllers\Frontend\json_data\PostController@show
      namespace
      where
      file
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      receivinghelpdeskask
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        3.95ms/app/Providers/RouteServiceProvider.php:54receivinghelpdeskask
        Metadata
        Bindings
        • 0. 2025-06-25 07:08:47
        • 1. how-does-zofran-work
        Backtrace
        • 15. /app/Providers/RouteServiceProvider.php:54
        • 18. /vendor/laravel/framework/src/Illuminate/Routing/Router.php:842
        • 19. Route binding:39
        • 20. /vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:167
        • 21. /vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:78
      • select * from `json_post_contents` where `json_post_contents`.`post_id` = 91715 and `json_post_contents`.`post_id` is not null and `rewrite_id` = 0
        14.72msmiddleware::checkdate:30receivinghelpdeskask
        Metadata
        Bindings
        • 0. 91715
        • 1. 0
        Backtrace
        • 19. middleware::checkdate:30
        • 20. /vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:167
        • 21. /vendor/laravel/jetstream/src/Http/Middleware/ShareInertiaData.php:61
        • 22. /vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:167
        • 23. /vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • select * from `nova_menu_menus` where `slug` = 'header' limit 1
        290μs/vendor/outl1ne/nova-menu-builder/src/helpers.php:32receivinghelpdeskask
        Metadata
        Bindings
        • 0. header
        Backtrace
        • 15. /vendor/outl1ne/nova-menu-builder/src/helpers.php:32
        • 17. /vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 18. /vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:45
        • 19. /vendor/laravel/framework/src/Illuminate/Routing/Route.php:261
        • 20. /vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
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        290μs/vendor/outl1ne/nova-menu-builder/src/Models/Menu.php:35receivinghelpdeskask
        Metadata
        Bindings
        • 0. 1
        Backtrace
        • 19. /vendor/outl1ne/nova-menu-builder/src/Models/Menu.php:35
        • 20. /vendor/outl1ne/nova-menu-builder/src/helpers.php:33
        • 22. /vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 23. /vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:45
        • 24. /vendor/laravel/framework/src/Illuminate/Routing/Route.php:261
      • select * from `nova_menu_menu_items` where `nova_menu_menu_items`.`parent_id` in (1) order by `order` asc
        320μs/vendor/outl1ne/nova-menu-builder/src/Models/Menu.php:35receivinghelpdeskask
        Metadata
        Backtrace
        • 24. /vendor/outl1ne/nova-menu-builder/src/Models/Menu.php:35
        • 25. /vendor/outl1ne/nova-menu-builder/src/helpers.php:33
        • 27. /vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 28. /vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:45
        • 29. /vendor/laravel/framework/src/Illuminate/Routing/Route.php:261
      • select `id`, `post_title`, `slug` from `posts` where `status` = 'publish' and `posts`.`deleted_at` is null order by RAND() limit 10
        3.35s/app/View/Composers/SidebarView.php:22receivinghelpdeskask
        Metadata
        Bindings
        • 0. publish
        Backtrace
        • 14. /app/View/Composers/SidebarView.php:22
        • 15. /app/View/Composers/SidebarView.php:12
        • 16. /vendor/laravel/framework/src/Illuminate/View/Concerns/ManagesEvents.php:124
        • 17. /vendor/laravel/framework/src/Illuminate/View/Concerns/ManagesEvents.php:162
        • 20. /vendor/laravel/framework/src/Illuminate/View/Concerns/ManagesEvents.php:177
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        540μsview::2dd102cf0462e89a4d4d8bc77355d767652bf9aa:15receivinghelpdeskask
        Metadata
        Bindings
        • 0. 48088
        Backtrace
        • 21. view::2dd102cf0462e89a4d4d8bc77355d767652bf9aa:15
        • 23. /vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:108
        • 24. /vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • 25. /vendor/livewire/livewire/src/ComponentConcerns/RendersLivewireComponents.php:69
        • 26. /vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:61
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      Outl1ne\MenuBuilder\Models\MenuItem
      1
      Outl1ne\MenuBuilder\Models\Menu
      1
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      1
      App\Models\Post
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