Clinical Trials Experience
| Body System Adverse Reaction | Treatment Number (%) of Women | Treatment Number (%) of Women |
| Body System Adverse Reaction | Placebo N = 47 n (%) | Vagifem N = 91 n (%) |
| Headache | 3 (6) | 8 (9) |
| Abdominal Pain | 2 (4) | 6 (7) |
- nausea, vomiting, bloating, stomach cramps;
- headache;
- swelling in your hands or feet, weight gain;
- breast pain; or.
- vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.
What are the side effects of estradiol?
One major report that looks set to tackle these anxieties was published in 2021 and found that previous research about a link between hormone replacement therapy ... It also has helpful effects on cholesterol, increasing HDL cholesterol (the good kind ...
Should I take estradiol?
You should not use this medicine if you are allergic to estradiol, or if you have:
- unusual vaginal bleeding that has not been checked by a doctor;
- liver disease;
- a history of heart attack, stroke, or blood clot;
- an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; or
- a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Does estradiol cause vaginal discharge?
vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Estradiol topical side effects (more detail)
How do I avoid estradiol side effects?
Side effects requiring immediate medical attention
- Change in vaginal discharge
- clear or bloody discharge from the nipple
- decrease in the amount of urine
- dimpling of the breast skin
- fast heartbeat
- fever
- hives, itching, or rash
- hoarseness
- inverted nipple
- irritation
What are the most common side effects of estradiol?
The most common side effects of estradiol hormone replacement therapy are bloating, nausea, indigestion, headaches, vaginal bleeding, breast tenderness/swelling, leg cramps, and fluid retention. These side effects are usually temporary and normally resolve in a few weeks once your body adjusts to estradiol.
Does vaginal estrogen have any side effects?
Vaginal estrogen may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: breast pain or tenderness. nausea.
Are estradiol vaginal inserts safe to use?
Using this medicine may increase your risk of dementia, especially in women 65 years of age and older. Using this medicine may increase your risk for having blood clots, strokes, or heart attacks. This risk may continue even after you stop using the medicine.
What is estradiol side effects?
Side effects associated with use of Estradiol, include the following:Abdominal cramping.Anxiety.Bloating.Breakthrough bleeding.Breast enlargement.Breast tenderness/pain/swelling.Freckles or darkening of facial skin (melasma)Changes in menstrual periods.More items...
Does estradiol cause weight gain?
For women, a specific estrogen hormone called estradiol decreases at menopause helps regulate metabolism and body weight. The lower the levels of estradiol may cause weight gain. Throughout a woman's life, they may notice weight gain around their hips and thighs.
Should I take estradiol in the morning or at night?
Adults—One capsule once a day, in the evening. Each capsule contains 1 milligram (mg) estradiol and 100 mg progesterone. Children—Use is not recommended.
How long should a woman take estradiol?
Five years or less is usually the recommended duration of use for this combined treatment, but the length of time can be individualized for each woman.
How long does estradiol vaginal inserts take to work?
In as fast as 2 weeks, IMVEXXY starts treating the actual problem behind vaginal pain and discomfort due to estrogen loss. In a study of menopausal women who used IMVEXXY for 12 weeks, most experienced relief from moderate to severe painful sex. In fact, many women started experiencing relief in as fast as 2 weeks.
Can estradiol make your hair fall out?
When the levels of estrogen and progesterone drop, hair grows more slowly and becomes much thinner. A decrease in these hormones also triggers an increase in the production of androgens, or a group of male hormones. Androgens shrink hair follicles, resulting in hair loss on the head.
How does estradiol make you feel?
Stomach upset, nausea/vomiting, bloating, breast tenderness, headache, or weight changes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Tell your doctor promptly if you see the tablet in your stool.
What are the benefits of taking estradiol?
Estradiol is a female sex hormone and a form of estrogen that is often prescribed to treat the symptoms of menopause and to prevent osteoporosis.
What is the best time of day to take estradiol?
DosingAdults—One capsule once a day, in the evening. Each capsule contains 1 milligram (mg) estradiol and 100 mg progesterone.Children—Use is not recommended.
What are some other side effects of Estradiol Vaginal Tablets?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
What are some things I need to know or do while I take Estradiol Vaginal Tablets?
Tell all of your health care providers that you take this medicine (estradiol vaginal tablets). This includes your doctors, nurses, pharmacists, and dentists.
What do I need to tell my doctor BEFORE I take Estradiol Vaginal Tablets?
If you have an allergy to estradiol or any other part of this medicine (estradiol vaginal tablets).
How is this medicine (Estradiol Vaginal Tablets) best taken?
Use this medicine (estradiol vaginal tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
Can you take estradiol while pregnant?
If you are pregnant or may be pregnant. Do not take this medicine (estradiol vaginal tablets) if you are pregnant.
Can estrogen cause uterine cancer?
Estrogens may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to the doctor.
Can estrogen cause a heart attack?
Using estrogens may raise the chances of having a heart attack, a stroke, breast cancer, ovarian cancer, a blood clot, or dementia. Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.
What are the side effects of Estradiol?
Check with your doctor immediately if any of the following side effects occur while taking estradiol: Less common. Vaginal yeast infection. Incidence not known. Change in vaginal discharge. clear or bloody discharge from the nipple. decrease in the amount of urine. dimpling of the breast skin. fast heartbeat.
What are the symptoms of overdose on estradiol?
swelling of the eyelids, face, fingers, lips, hands, feet, or lower legs. tightness in the chest. troubled breathing at rest . troubled breathing or swallowing. vaginal bleeding. Get emergency help immediately if any of the following symptoms of overdose occur while taking estradiol: Symptoms of overdose. Dizziness.
What are the risks of a postmenopausal woman?
Increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) have been reported.
What does it mean when you feel pressure in your pelvis?
pain or feeling of pressure in the pelvis. pain, redness, or swelling in the arm or leg. persistent crusting or scaling of the nipple. redness of the skin. redness or swelling of the breast. sore on the skin of the breast that does not heal. swelling of the eyelids, face, fingers, lips, hands, feet, or lower legs.
Can estrogen cause cancer?
Estrogens increase the risk of endometrial cancer; monitor for abnormal vaginal bleeding. Estrogens with or without progestins should not be used for the prevention of cardiovascular disease or dementia. Increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) have been reported. An increased risk of developing probable dementia in postmenopausal women 65 years of age or older has also been reported in women receiving estrogen alone or estrogen combined with progestins. Risks should be assumed to be similar for other doses, combinations, and dosage forms of estrogens and progestins. Estrogens, with or without progestins, should be prescribed at the lowest effective doses and for the shortest duration possible.
Can estrogen be prescribed with progestins?
Estrogens, with or without progestins, should be prescribed at the lowest effective doses and for the shortest duration possible.
Does estradiol cause a rash?
Commonly reported side effects of estradiol include: cerebrovascular accident, infection, malignant neoplasm of breast, endometrium disease, headache, and mastalgia. Other side effects include: abdominal pain, limb pain, pruritus, sinusitis, nausea, skin rash, and vaginitis. See below for a comprehensive list of adverse effects.
What other drugs will affect estradiol vaginal?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
How should I use estradiol vaginal?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
What is estradiol vaginal (systemic)?
Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.
How to get a ring out of your vagina?
Do not use an extra vaginal ring to make up the missed wearing time. If a vaginal ring falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use your finger to push it in farther.
Can estradiol be used for vaginal purposes?
Estradiol vaginal (systemic) may also be used for purposes not listed in this medication guide.
Can grapefruit be used with estradiol?
Grapefruit may interact with estradiol and lead to unwanted side effects. Avoid the use of grapefruit products.
Does estradiol cause hot flashes?
Other vaginal estradiol products are used for treating vaginal menopause symptoms and symptoms that affect other parts of the body (such as hot flashes ). This type of vaginal estradiol has "systemic" effects, meaning that it can affect parts of the body other than where the medicine is directly applied.
What are the side effects of a syringe?
Side effects that you should report to your doctor or health care professional as soon as possible: 1 allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue 2 breast tissue changes or discharge 3 changes in vision 4 chest pain 5 confusion, trouble speaking or understanding 6 dark urine 7 general ill feeling or flu-like symptoms 8 light-colored stools 9 nausea, vomiting 10 pain, swelling, warmth in the leg 11 right upper belly pain 12 severe headaches 13 shortness of breath 14 sudden numbness or weakness of the face, arm or leg 15 trouble walking, dizziness, loss of balance or coordination 16 unusual vaginal bleeding 17 yellowing of the eyes or skin
What should I watch for while using this medicine?
Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.
What are the conditions that a doctor needs to know about a woman?
They need to know if you have any of these conditions: abnormal vaginal bleeding. blood vessel disease or blood clots. breast, cervical, endometrial, ovarian, liver, or uterine cancer. dementia . diabetes. gallbladder disease. heart disease or recent heart attack. high blood pressure.
Can you stop taking a sulfate pill while pregnant?
If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.
What are the side effects of a syringe?
rash. shortness of breath. skin redness. swelling of eyelids, face, lips, hands, or feet. tightness in the chest. trouble with breathing or swallowing. vomiting. wheezing. Some side effects may occur that usually do not need medical attention.
Can you take estrogen vaginally?
The risk of any serious adverse effect is unlikely for most women using low doses of estrogens vaginally. Even women with special risks have used vaginal estrogens without problems.
Can you have monthly bleeding after hysterectomy?
However, monthly bleeding will not occur in women who have had the uterus removed by surgery (hysterectomy). Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects.
Does estrogen cause vaginal bleeding?
Also, many women who are using estrogens with a progestin (another female hormone) will start having monthly vaginal bleeding that is similar to menstrual periods. This effect will continue for as long as the medicine is taken. However, monthly bleeding will not occur in women who have had the uterus removed by surgery (hysterectomy).
How to report Estradiol side effects in Canada?
In Canada - Call your doctor for medical advice about side effects . You may report side effects to Health Canada at 1-866-234-2345. Precautions. Before using estradiol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
What to do if side effects persist?
If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Can you take estrogen if you have surgery?
Tell your doctor if you just had or will be having surgery, or if you will be confined to a chair or bed for a long time (such as a long plane flight). These conditions increase your risk of getting blood clots, especially if you are using an estrogen product. You may need to stop this medication for a time or take special precautions.
Can you take estrogen through the skin?
Estrogens that are taken by mouth, absorbed through the skin, or injected may have greater risks of side effects due to more estrogen being absorbed.
Can estrogen cause cancer?
Estrogens can increase the risk of cancer of the uterus ( endometrial cancer ). Taking a progestin as directed by your doctor can help decrease this risk. Tell your doctor right away if you have any unusual vaginal bleeding.
Can estrogen be used with progestin?
estradiol vaginal. Warnings: Estrogens, either used alone or with another hormone ( progestin ), have rarely caused very serious side effects. Discuss the risks and benefits of hormone treatment with your doctor. Estrogens should not be used to prevent heart disease or dementia.
Can estrogen cause heart disease?
Estrogen, when used with a progestin, can increase the risk of heart disease (such as heart attacks ), stroke, serious blood clots in the lungs /legs, dementia, and cancer of the breast /ovaries. The risk for serious side effects may depend on the dose of estrogen and the length of time it is used.
What is the name of the allergic reaction to a drug?
a significant type of allergic reaction called anaphylaxis. a type of allergic reaction called angioedema. a hypersensitivity reaction to a drug. cancer of the uterus.
Are you currently using estradiol tablet?
This survey is being conducted by the WebMD marketing sciences department.
What are the side effects of Estradiol vaginal tablet (Vagifem)?
With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.
How much does Estradiol vaginal tablet (Vagifem) cost?
For even more savings, use a GoodRx coupon and pay just a fraction of the retail price.
What hormones can you take with a vaginal tablet?
If you still have your uterus, you have to use Estradiol vaginal tablet (Vagifem) with another hormone called progestin to lower your risk of uterine cancer.
Why does my vagina feel dry?
Vaginal dryness, thinning, and irritation caused by menopause
Is vaginal estradiol safe?
A small study showed that people using Estradiol vaginal tablet (Vagifem) for a year had a very low risk of these problems, so researchers believe this is a safer option than oral pills. Discuss your personal risks with your provider before using Estradiol vaginal tablet (Vagifem). Together, you'll decide how long you should use this medication.
Can vaginal irritability be caused by esradiol?
Some people find that the Estradiol vaginal tablet (Vagifem) applicators cause vaginal irritation right after they insert the medication. This is more likely to happen if your menopause symptoms are more severe. This side effect typically gets better or goes away after the medication starts to relieve your vaginal dryness. If the irritation you experience gets worse or is very bothersome, speak with your provider.
Can you take esradiol while pregnant?
Estradiol vaginal tablet (Vagifem) is processed by the liver, so if it's not working properly, you might experience more side effects from this medication. Because of this, if you have or have had any problems with your liver, including liver problems during a past pregnancy, you should not use Estradiol vaginal tablet (Vagifem).
in Summary
For The Consumer
- Applies to estradiol: vaginal capsule liquid filled, vaginal cream, vaginal insert extended release, vaginal tablet Other dosage forms: 1. transdermal gel/jelly, transdermal patch extended release, transdermal spray
For Healthcare Professionals
- Applies to estradiol: compounding powder, intramuscular solution, oral tablet, transdermal emulsion, transdermal film extended release, transdermal gel, transdermal spray, vaginal ring
Further Information
- Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Some side effects may not be reported. You may report them to the FDA. Medical Disclaimer