Clinical Trials Experience
| Body System Adverse Reaction | Treatment | Treatment |
| Body System Adverse Reaction | Number (%) of Women Placebo N = 47 n (%) | Yuvafem N = 91 n (%) |
| Headache | 3 (6) | 8 (9) |
| Abdominal Pain | 2 (4) | 6 (7) |
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue.
- breast tissue changes or discharge.
- changes in vision.
- chest pain.
- confusion, trouble speaking or understanding.
- dark urine.
- general ill feeling or flu-like symptoms.
What are the side effects of estradiol?
One major report that looks set to tackle these anxieties was published in 2021 and found that previous research about a link between hormone replacement therapy ... It also has helpful effects on cholesterol, increasing HDL cholesterol (the good kind ...
What are the side effects of lack of estrogen?
Symptoms of low estrogen may include the following:
- Irregular periods: Estrogen is one of the main hormones driving the menstrual cycle. ...
- Infertility: Low estrogen levels can prevent ovulation and make getting pregnant difficult, leading to infertility.
- Weak bones: Estrogen helps keep the bones healthful and strong. ...
- Painful intercourse: Estrogen can affect vaginal lubrication. ...
Does estradiol increase appetite?
When injected with estradiol, their normal feeding and weight behaviors are restored. In contrast to estrogen, progesterone appears to increase appetite. When administered high doses, ovariectomized rats eat more. This happens in humans as well, and most especially when in the presence of estrogen.
When to take estradiol?
You should not use this medicine if you are allergic to estradiol, or if you have:
- unusual vaginal bleeding that has not been checked by a doctor;
- liver disease;
- a history of heart attack, stroke, or blood clot;
- an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; or
- a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
What are common side effects of estradiol?
Stomach upset, nausea/vomiting, bloating, breast tenderness, headache, or weight changes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Tell your doctor promptly if you see the tablet in your stool.
Is weight gain a side effect of estradiol?
Weight Gain & Oral Estrogen Topical, but not oral, estradiol prevents this increase in body fat and leptin. An interesting fact about visceral obesity is that women who take NO estrogen can also get weight gain around their middle because they develop insulin resistance.
Should I take estradiol in the morning or at night?
Adults—One capsule once a day, in the evening. Each capsule contains 1 milligram (mg) estradiol and 100 mg progesterone. Children—Use is not recommended.
Will estradiol help with weight loss?
One form of estrogen called estradiol decreases at menopause. This hormone helps to regulate metabolism and body weight. Lower levels of estradiol may lead to weight gain.
Can estrogen cause a heart attack?
Using estrogens may raise the chances of having a heart attack, a stroke, breast cancer, ovarian cancer, a blood clot, or dementia. Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.
Can a drug cause side effects?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Hair loss .
Can you take estradiol by mouth?
Do not take estradiol vaginal insert by mouth. For vaginal use only. Keep out of your mouth, nose, and eyes (may burn). Use estradiol vaginal insert at the same time of day. Put into the vagina as you have been told by your doctor. Be sure you know how often to do this and what dose to use.
Can you smoke Estradiol?
This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take estradiol vaginal insert. Do not smoke. Smoking raises the chance of heart disease. Talk with your doctor. If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
Can estrogen cause uterine cancer?
Estrogens may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to the doctor.
Can you take Estradiol vaginal insert while pregnant?
Do not take estradiol vaginal insert if you are pregnant. If you are breast-feeding or plan to breast-feed. This is not a list of all drugs or health problems that interact with estradiol vaginal insert. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems.
What are the effects of cytochrome P450 3A4 on estrogen?
Inducers of CYP3A4, such as St. John's wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin, may reduce plasma concentrations of estrogens, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile. Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase plasma concentrations of estrogens and may result in side effects.
What is the USP for vaginal inserts?
Estradiol Vaginal Inserts, USP are a white to off-white, round, film-coated, biconvex vaginal insert debossed with 'G' on one side and '94' on the other side and containing 10 mcg of estradiol. Each vaginal insert is 6 mm in diameter and is administered in a disposable applicator.
How many mcg is a vaginal insert?
Estradiol Vaginal Inserts USP, 10 mcg are white to off-white, round, film-coated, bi-convex vaginal inserts, debossed with ‘G’ on one side and ‘94’ on the other side and containing 10.3 mcg of estradiol hemihydrate equivalent to 10 mcg of estradiol.
Can you use estrogen inserts during pregnancy?
Estradiol Vaginal Inserts should not be used during pregnancy [see Contraindications ( 4 )]. There appears to be little or no increased risk of birth defects in children born to women who have used estrogens and progestins as an oral contraceptive inadvertently during early pregnancy.
Does estrogen increase TBG?
Estrogen administration leads to increased thyroid-binding globulin (TBG) levels. Women with normal thyroid function can compensate for the increased TBG by making more thyroid hormone, thus maintaining free T 4 and T 3 serum concentrations in the normal range. Women dependent on thyroid hormone replacement therapy who are also receiving estrogens may require increased doses of their thyroid replacement therapy. These women should have their thyroid function monitored in order to maintain their free thyroid hormone levels in an acceptable range.
Can estrogen be metabolized?
Estrogens may be poorly metabolized in women with impaired liver function. For women with a history of cholestatic jaundice associated with past estrogen use or with pregnancy, caution should be exercised, and in the case of recurrence, medication should be discontinued.
Does estrogen help with endometrial cancer?
Generally, when estrogen is prescribed for a postmenopausal woman with a uterus, a progestin should also be considered to reduce the risk of endometrial cancer. A woman without a uterus does not need a progestin.
What is estradiol used for?
Some estradiol products placed directly into the vagina are used for "local" treatment of vaginal menopause symptoms (such as dryness, burning, and irritation). Other vaginal estradiol products are used for treating vaginal menopause symptoms and symptoms that affect other parts of the body (such as hot flashes ).
How to get a ring out of your vagina?
Do not use an extra vaginal ring to make up the missed wearing time. If a vaginal ring falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use your finger to push it in farther.
Can estradiol cause uterine cancer?
Call your doctor if you have trouble removing a vaginal ring. Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Call your doctor at once if you have any unusual vaginal bleeding while using estradiol vaginal.
Can you take estradiol while pregnant?
Do not use if you are pregnant. Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away. Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries.
Can etradiol be used for heart disease?
Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions. Tell your doctor if you have ever had: heart disease; liver problems, or jaundice caused by pregnancy or taking hormones; kidney disease;
Can you take Estradiol and other medications at the same time?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can affect estradiol.
Does calcium cause bloating?
high levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy. Common side effects may include: nausea, vomiting, bloating, stomach cramps; headache; breast pain or tenderness; swelling in your hands or feet, weight gain;
How to report Estradiol side effects in Canada?
In Canada - Call your doctor for medical advice about side effects . You may report side effects to Health Canada at 1-866-234-2345. Precautions. Before using estradiol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Can estrogen cause heart attacks?
When used along with a progestin, estrogens also increase the risk of heart disease (such as heart attacks ). The risk for serious side effects may depend on the dose ...
Can estrogen be used for heart disease?
Estrogens should not be used to prevent heart disease or dementia. Estrogens can increase the risk of cancer of the uterus ( endometrial cancer ). Taking a progestin as directed by your doctor can help decrease this risk. Tell your doctor right away if you have any unusual vaginal bleeding. In postmenopausal women, estrogens, taken with ...
Can you take estrogen through the skin?
Estrogens that are taken by mouth, absorbed through the skin, or injected may have greater risks of side effects due to more estrogen being absorbed.
Is estrogen safe to take at the lowest dose?
Therefore, this medication should be used at the lowest effective dose and for the shortest amount of time.
How to report side effects to FDA?
You may report side effects to FDA at 1-800-FDA-1088. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Is Yuvafem 25 mg a causal relationship?
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Can you take yuvafem while pregnant?
Yuvafem is not intended for use during pregnancy. Estrogen administration to nursing women has been shown to decrease the quantity and quality of the breast milk. Yuvafem is not recommended for use while breastfeeding.
Does calcium cause bloating?
high levels of calcium in your blood --nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy. Common side effects may include: nausea, vomiting, bloating, stomach cramps; headache; swelling in your hands or feet, weight gain; breast pain; or. vaginal itching or discharge, changes in your menstrual ...
If experienced, these tend to have a Severe expression i
Sorry, we have no data available. Please contact your doctor or pharmacist.
Are you currently using estradiol tablet?
This survey is being conducted by the WebMD marketing sciences department.
What is estradiol vaginal (local)?
Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.
What are the possible side effects of estradiol vaginal (local)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
What is the most important information I should know about estradiol vaginal (local)?
You should not use estradiol if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus / cervix, or vagina.
What should I discuss with my healthcare provider before using estradiol vaginal (local)?
You should not use estradiol if you are allergic to it, or if you have:
How should I use estradiol vaginal (local)?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
What happens if I miss a dose?
Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What are the side effects of a syringe?
rash. shortness of breath. skin redness. swelling of eyelids, face, lips, hands, or feet. tightness in the chest. trouble with breathing or swallowing. vomiting. wheezing. Some side effects may occur that usually do not need medical attention.
Can you have monthly bleeding after hysterectomy?
However, monthly bleeding will not occur in women who have had the uterus removed by surgery (hysterectomy). Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects.