Can Zyprexa be crushed? You can take olanzapine with or without food. Take olanzapine at the time (s) recommended by your doctor. You can cut or crush the tablet. Click to see full answer. Moreover, can Seroquel be crushed? You can take the immediate-release tablet with or without food. You can cut or crush quetiapine immediate-release tablets.
Can Zyprexa be reconstituted with saline?
• ZYPREXA IM should be reconstituted only with sterile water for injection. • ZYPREXA IM should not be combined in a syringe nor should be used simultaneously with parenteral benzodiazepines (see 4.4 Special warnings and precautions for use). • ZYPREXA IM should not be combined in a syringe with haloperidol injection because
Can Zyprexa cause aggressive behavior?
Typically the only times that Zyprexa causes aggression in individuals is if the dosage is too high. Given the fact that her behavior didn't cease once started on the zyprexa her doctor should have discontinued the medication and explored another medication such as Risperdal or Abilify.
Can Zyprexa tablets be cut in half?
patients should be cautioned that because of the coating of Zyprexa, split tablets must be used within seven days . However, the tablets can be difficult to split because they tend to be very small.
Can you mix Darvocet with Zyprexa?
ZYPREXA IntraMuscular should not be combined in a syringe with diazepam injection because precipitation occurs when these products are mixed. Lorazepam injection should not be used to reconstitute ZYPREXA IntraMuscular as this combination results in a delayed reconstitution time.
Can you dissolve Zyprexa?
Zyprexa Zydis is placed on the tongue. The tablet will disintegrate quickly in your saliva so that you can easily swallow it with or without drinking liquid. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
Can you dissolve Zyprexa in water?
Olanzapine is a yellow crystalline solid, which is practically insoluble in water. ZYPREXA tablets are intended for oral administration only.
Can you crush olanzapine ODT?
Do not swallow it whole. Do not chew, break, or crush it.
Can you chew Zyprexa?
Olanzapine can be taken with or without food. Remove an orally disintegrating tablet (Zyprexa Zydis) from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves.
What medications can you not crush?
If chewed and swallowed, may result in a lower peak concentration and bioavailability. Irritant; Note: chewed, crushed, or sucked tablets may cause oropharyngeal ulceration. Slow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal dose.
How long does olanzapine take to dissolve?
Phenylalanine (0.34, 0.45, 0.67, or 0.90 mg per 5, 10, 15, or 20 mg ODO tablet, respectively) is also included (US prescribing information available from: http://pi.lilly.com/us/zyprexa-pi.pdf). ODO tablets dissolve in human saliva in seconds.
Can you break olanzapine ODT in half?
If you split the tablet as part of your dose, the half-tablet that is not taken should be destroyed. Do not save this half-tablet for later use. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Can you swallow olanzapine ODT tablets?
These film coated tablets should be swallowed whole with a glass of water. Olanzapine AN ODT: These orally disintegrating tablets will dissolve in your mouth, therefore do not require water.
What is the difference between olanzapine and olanzapine ODT?
Oral olanzapine is available in the form of ODTs and standard oral tablets (SOT). The ODT formulation of olanzapine is designed to dissolve upon contact with saliva and cannot be easily spat out,8 and may be preferable for patients who are reluctant or unable to swallow tablets.
Can olanzapine 5mg be cut in half?
You can take olanzapine with or without food. Take olanzapine at the time(s) recommended by your doctor. You can cut or crush the tablet.
How long does Zyprexa take to kick in?
Olanzapine does not work straight away. It may take several days, or even weeks, for some of your symptoms to start improving. Soon after you first start taking olanzapine, before your other symptoms improve, it may make you feel more relaxed and calm.
Is 5mg of Zyprexa a lot?
Adults—At first, 10 to 15 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day. Children 13 to 17 years of age—At first, 2.5 or 5 mg once a day.
Before Taking This Medicine
You should not take Zyprexa if you are allergic to olanzapine.Zyprexa is not approved for use in psychotic conditions related to dementia. Olanzapi...
How Should I Take Zyprexa?
Take Zyprexa exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include drowsiness, agitation, aggression, sl...
What Should I Avoid While Taking Zyprexa?
Zyprexa may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.Avoid getting up too fast from...
What Other Drugs Will Affect Zyprexa?
Using Zyprexa with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor be...
Does chewing Xanax make it work faster?
Chewing Xanax This increases the surface area of the drug. As a result, the many small pieces are absorbed into the bloodstream quicker. This causes the drug to get to the brain faster. Moreover, more of the drug gets to the brain at once.
Can you crush metformin 500 mg?
You can crush standard metformin tablets using a pill crusher. You can get a pill crusher from most chemists. You can add crushed medicine to your food. You cannot crush modified release metformin.
Does quetiapine calm you down?
Quetiapine is used for schizophrenia and mania. Quetiapine is sometimes used for people who have behaviour problems. For example, it could… • help if you are anxious • help calm you down • help you feel less angry • help you feel less tense. Quetiapine should help you feel calm and relaxed.
Does Seroquel feel like Xanax?
Seroquel (quetiapine) and Xanax (alprazolam) are used to treat psychiatric disorders. Seroquel is used to treat schizophrenia, major depression, and bipolar disorder. Xanax is prescribed to treat panic attacks and anxiety disorders. Seroquel is an antipsychotic medication and Xanax is a benzodiazepine.
Can film coated tablets be crushed?
Sugar or film coating – surrounds the tablet to make it taste better. Crushing these types of tablets may make them to taste very unpleasant. These tablets should never be crushed as this would release all of the medicine very quickly which could be harmful.
Can you crush metoprolol?
Metoprolol should be taken with a meal or just after a meal. Take the medicine at the same time each day. Swallow the capsule whole and do not crush, chew, break, or open it. A Toprol XL tablet can be divided in half if your doctor has told you to do so.
What does Seroquel do to a normal person?
Seroquel is the brand name of the generic drug quetiapine, used to treat schizophrenia and bipolar disorder (formerly known as manic-depression). Seroquel changes the levels of neurotransmitters (naturally occurring brain substances) including serotonin and dopamine.
How many patients were in the premarketing trial of olanzapine?
In premarketing trials involving more than 3100 patients and/or normal subjects, accidental or intentional acute overdosage of olanzapine was identified in 67 patients. In the patient taking the largest identified amount, 300 mg, the only symptoms reported were drowsiness and slurred speech. In the limited number of patients who were evaluated in hospitals, including the patient taking 300 mg, there were no observations indicating an adverse change in laboratory analytes or ECG. Vital signs were usually within normal limits following overdoses.
How long does it take for olanzapine to be absorbed?
Oral Administration, Monotherapy — Olanzapine is well absorbed and reaches peak concentrations in approximately 6 hours following an oral dose. It is eliminated extensively by first pass metabolism, with approximately 40% of the dose metabolized before reaching the systemic circulation. Food does not affect the rate or extent of olanzapine absorption. Pharmacokinetic studies showed that Zyprexa tablets and Zyprexa ZYDIS (olanzapine orally disintegrating tablets) dosage forms of olanzapine are bioequivalent.
Does Zyprexa affect fertility?
Based on the pharmacologic action of olanzapine (D 2 receptor antagonism), treatment with Zyprexa may result in an increase in serum prolactin levels, which may lead to a reversible reduction in fertility in females of reproductive potential [see Warnings and Precautions ( 5.15 )].
Does olanzapine affect prolactin?
As with other drugs that antagonize dopamine D 2 receptors, olanzapine elevates prolactin levels, and the elevation persists during chronic administration. Hyperprolactinemia may suppress hypothalamic GnRH, resulting in reduced pituitary gonadotropin secretion. This, in turn, may inhibit reproductive function by impairing gonadal steroidogenesis in both female and male patients. Galactorrhea, amenorrhea, gynecomastia, and impotence have been reported in patients receiving prolactin-elevating compounds. Long-standing hyperprolactinemia when associated with hypogonadism may lead to decreased bone density in both female and male subjects.
Does olanzapine cause constipation?
Olanzapine exhibits in vitro muscarinic receptor affinity [see Clinical Pharmacology 12.2]. In premarketing clinical trials, Zyprexa was associated with constipation, dry mouth, and tachycardia, all adverse reactions possibly related to cholinergic antagonism. Such adverse reactions were not often the basis for discontinuations, but Zyprexa should be used with caution in patients with a current diagnosis or prior history of urinary retention, clinically significant prostatic hypertrophy, constipation, or a history of paralytic ileus or related conditions. In post marketing experience, the risk for severe adverse reactions (including fatalities) was increased with concomitant use of anticholinergic medications [see Drug Interactions ( 7.1 )].
Is olanzapine safe for Alzheimer's patients?
Olanzapine should be used cautiously in patients with a history of seizures or with conditions that potentially lower the seizure threshold, e.g., Alzheimer's dementia. Olanzapine is not approved for the treatment of patients with Alzheimer's disease. Conditions that lower the seizure threshold may be more prevalent in a population of 65 years or older.
Is Olanzapine approved for Alzheimer's?
Aspiration pneumonia is a common cause of morbidity and mortality in patients with advanced Alzheimer's disease. Olanzapine is not approved for the treatment of patients with Alzheimer's disease.
What is zyprexa used for?
Zyprexa is used to treat psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults and children at least 13 years old. Zyprexa is also used together with fluoxetine ( Prozac) to treat episodes of depression in adults ...
What happens if you take antipsychotics while pregnant?
Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away.
Can olanzapine cause bruising?
Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. High doses or long-term use of olanzapine can cause a serious movement disorder that may not be reversible.
Can you take zyprexa if you are allergic to olanzapine?
Before taking this medicine. You should not take Zyprexa if you are allergic to olanzapine. Zyprexa may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use. To make sure this medicine is safe for you, tell your doctor if you have ever had: liver disease;
Can you take zyprexa with other drugs?
Taking Zyprexa with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Can Olanzapine cause high blood sugar?
Swallow several times as the tablet dissolves. Olanzapine can cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis. You may gain weight or have high cholesterol and triglycerides (types of fat) while taking this medicine, especially if you are a teenager.
Can you drink alcohol while taking Zyprexa?
Avoid drinking alcohol while taking Zyprexa. Zyprexa is not approved for use in older adults with dementia-related psychosis. You may gain weight or have high cholesterol and triglycerides (types of fat) while taking this medicine, especially if you are a teenager. Your blood may need to be tested often.
Other warnings
Olanzapine is a prescription drug. It comes in the form of a tablet and a disintegrating tablet. (The disintegrating tablet will dissolve on your tongue.) Both forms are taken by mouth.
How it works
Olanzapine belongs to a class of drugs called atypical antipsychotics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
More common side effects
The adult side effects for olanzapine are slightly different from the side effects for children.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
Interactions that increase your risk of side effects
Fluvoxamine. Increased side effects can include tremor (shakes). To avoid this problem, your doctor may lower your olanzapine dosage.
Interactions that can make your drugs less effective
When olanzapine is less effective: When olanzapine is used with certain drugs, it may not work as well to treat your condition. This is because the amount of olanzapine in your body may be decreased. Examples of these drugs include: Anticonvulsants, such as phenytoin or carbamazepine. Your doctor may lower your dosage of these drugs. Rifampin.
Allergy warning
Olanzapine can cause a severe allergic reaction. Symptoms can include:
What is the chemical name of zyprexa?
ZYPREXA (olanzapine) is a psychotropic agent that belongs to the thienobenzodiazepine class. Thechemical designation is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b] [1,5]benzodiazepine.The molecular formula is C17H20N4S, which corresponds to a molecular weight of 312.44. The chemicalstructure is:
How many patients were in the premarketing trial of olanzapine?
Human Experience--In premarketing trials involving more than 3100 patients and/or normal subjects,accidental or intentional acute overdosage of olanzapine was identified in 67 patients. In the patienttaking the largest identified amount, 300 mg, the only symptoms reported were drowsiness and slurredspeech. In the limited number of patients who were evaluated in hospitals, including the patient taking300 mg, there were no observations indicating an adverse change in laboratory analytes or ECG. Vitalsigns were usually within normal limits following overdoses.
How much olanzapine should I take for schizophrenia?
SchizophreniaUsual Dose--Olanzapine should be administered on a once-a-day schedule without regard to meals,generally beginning with 5 to 10 mg initially, with a target dose of 10 mg/day within several days. Furtherdosage adjustments, if indicated, should generally occur at intervals of not less than 1 week, sincesteady state for olanzapine would not be achieved for approximately 1 week in the typical patient.When dosage adjustments are necessary, dose increments/decrements of 5 mg QD are recommended.Antipsychotic efficacy was demonstrated in a dose range of 10 to 15 mg/day in clinical trials.However, doses above 10 mg/day were not demonstrated to be more efficacious than the 10 mg/daydose. An increase to a dose greater than the target dose of 10 mg/day (i.e., to a dose of 15 mg/day orgreater) is recommended only after clinical assessment. The safety of doses above 20 mg/day has notbeen evaluated in clinical trials.
What is the short term placebo controlled trial?
Short-Term, Placebo-Controlled Trials--Table 1 enumerates the incidence, rounded to the nearest percent, of treatment-emergent adverseevents that occurred in 2% or more of patients treated with olanzapine (doses > 2.5 mg/day) and withincidence greater than placebo who participated in the acute phase of placebo-controlled trials.
Does olanzapine cause syncope?
GeneralOrthostatic Hypotension--Olanzapine may induce orthostatic hypotension associated with dizziness,tachycardia, and in some patients, syncope, especially during the initial dose-titration period, probablyreflecting its a1-adrenergic antagonistic properties. Syncope was reported in 0.6% (15/2500) ofolanzapine-treated patients in phase 2-3 studies. The risk of orthostatic hypotension and syncope maybe minimized by initiating therapy with 5 mg QD (see DOSAGE AND ADMINISTRATION). A moregradual titration to the target dose should be considered if hypotension occurs. Olanzapine should beused with particular caution in patients with known cardiovascular disease (history of myocardialinfarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatmentwith antihypertensive medications).
Is olanzapine a controlled substance?
Controlled Substance Class--Olanzapine is not a controlled substance. Physical and Psychological Dependence--In studies prospectively designed to assess abuse anddependence potential, olanzapine was shown to have acute depressive CNS effects but little or nopotential of abuse or physical dependence in rats administered oral doses up to 15 times the maximumrecommended human daily dose (20 mg) and rhesus monkeys administered oral doses up to 8 times themaximum recommended human daily dose on a mg/m2 basis.
Administration
Medical uses
Risks
Treatment
Symptoms
Contraindications
Research
Side effects
Preparation
- Directions for Preparation of Zyprexa IntraMuscular with Sterile Water for Injection Dissolve the contents of the vial using 2.1 mL of Sterile Water for Injection to provide a solution containing approximately 5 mg/mL of olanzapine. The resulting solution should appear clear and yellow. Zyprexa IntraMuscular reconstituted with Sterile Water for In...