What is the USP for bacteriostatic water for injection?
Bacteriostatic Water for Injection, USP must be made approximately isotonic prior to use. WARNINGS Benzyl alcohol, a preservative in Bacteriostatic Water for Injection, USP has been associated with toxicity in neonates. Data are unavailable on the toxicity of other preservatives in this age group.
What is a bacteriostatic water?
Bacteriostatic water is both a bacteriostatic agent and a key ingredient in laboratories, hospitals, and research centers around the world. Bacteriostatic agents have been used for as long as modern medicine has been practiced. These agents are used to prevent the growth of bacteria in different formulas, canisters, containers, and utensils.
Does bacteriostatic water for injection affect fluid balance?
The small volume of fluid provided by Bacteriostatic Water for Injection, USP when used only as a pharmaceutic aid for diluting or dissolving drugs for parenteral injection, is unlikely to exert a significant effect on fluid balance except possibly in very small infants.
How do you use a bacteriostatic syringe?
Insert the needle tip into the sealed bottle of bacteriostatic water. Slowly extract the bacteriostatic water until the solution reaches the desired level visible in the syringe body. Gently remove the needle from the bacteriostatic water vial. Penetrate the medication’s vial, as gently as you can.
Is bacteriostatic water prescription only?
Bacteriostatic Water is a prescription medicine used to dilute or dissolve medications. Bacteriostatic Water may be used alone or with other medications. Bacteriostatic Water belongs to a class of drugs called Sterile Irrigating Solutions.
How do you store bacteriostatic saline?
Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.]
Does Walgreens sell bacteriostatic water?
If you are needing bacteriostatic water for a medication today, you can shop around at various local pharmaceutical retailers, such as Walgreens, CVS, or Walmart.
Can bacteriostatic water be used more than once?
Bacteriostatic water can be used multiple times up to 28 days once opened. Pfizer recommends that after this time you must discard the vial. This preparation of sterile water and benzyl alcohol (BnOH) allows repeated withdrawals to be made from a single 30mL vial.
Does bacteriostatic water have to be refrigerated?
There are no special rules that need to be followed as far as discard. Keep your unused bacteriostatic water in the container it arrives in. Store the container in a dark place with a residual, resting room temperature that doesn't exceed 80 degrees Fahrenheit and doesn't drop below 60 degrees Fahrenheit.
Does sterile water for injection need to be refrigerated?
After initial entry, maintain contents at room temperature (25°C/77°F) and dispense within 4 hours. Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat. It is recommended the product be stored at room temperature (25°C/77°F).
Can I use sterile water instead of bacteriostatic water?
Do not use Bacteriostatic Water for Injection, USP for those products that specify the use of only Sterile Water for Injection, USP as a sterile solvent.
Is it safe to inject bacteriostatic water?
Dosage for Bacteriostatic Water It is not used for neonatal medications because of possible blood pressure changes and toxicity of benzyl alcohol. If Bacteriostatic Water is injected intravenously without any diluted compound, it may cause some red blood cell lysis because it is not isotonic.
Is 0.9% sodium chloride the same as bacteriostatic water?
Bacteriostatic 0.9% Sodium Chloride Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol added as a bacteriostatic preservative. May contain hydrochloric acid for pH adjustment.
Can you use bacteriostatic water for Botox?
TIP: Always use bacteriostatic normal saline as the diluent as per manufacturer guidance. Reconstituting with sterile water can cause the client great discomfort during treatment.
Can bacteria grow in sterile water?
Bacteriostatic water is sterile water that contains a bacteriostat, a chemical that prevents the growth of bacteria in the vial.
How do you store sterile water for injections?
Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents.
What is the pH of USP?
It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. The pH is 5.7 (4.5 to 7.0).
When to use aseptic technique?
Use aseptic technique for single or multiple entry and withdrawal from all containers. When diluting or dissolving drugs, mix thoroughly and use promptly. Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute.
What is the volume of the preparation to be used for diluting or dissolving any drug for injection?
The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer.
What is the purpose of the following preparation?
The following preparation is designed solely for parenteral use only after addition of drugs that require dilution or must be dissolved in an aqueous vehicle prior to injection. Bacteriostatic ... The following preparation is designed solely for parenteral use only after addition of drugs that require dilution or must be dissolved in an aqueous ...
What are the reactions that may occur because of this solution, added drugs or the technique of reconstitution or administration?
Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation.
Is USP made isotonic?
Bacteriostatic Water for Injection, USP must be made approximately isotonic prior to use.
Is parenteral preparation indicated for diluting or dissolving drugs for intravenous, intramuscular?
This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered.
What is the volume of the preparation to be used for diluting or dissolving any drug for injection?
The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer.Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.
Can you use a parenteral preparation as a diluent?
Use only as a diluent or solvent. This parenteral preparation is unlikely to pose a threat of fluid overload except possibly in very small infants. In the event these should occur, re-evaluate the patient and institute appropriate corrective measures. See WARNINGS, PRECAUTIONS and ADVERSE REACTIONS.
What is USP water?
Sterile Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection which contains no bacteriostat, antimicrobial agent or added buffer and is supplied only in single dose containers to dilute or dissolve drugs for injection.
What is parenteral preparation?
These parenteral preparations are indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the ... These parenteral preparations are indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, ...
What are the reactions that may occur because of this solution, added drugs or the technique of reconstitution or administration?
Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation.
Can you use sterile water for injection?
Where Water for Injection is required for preparing or diluting medications for use in newborns, only preservative-free Sterile Water for Injection should be used. Close. PRECAUTIONS. General - Do not use for intravenous injection unless the osmolar concentration of additives results in an approximate isotonic admixture.
What is bacteriostatic water?
Bacteriostatic water is both a bacteriostatic agent and a key ingredient in laboratories, hospitals, and research centers around the world. Bacteriostatic agents have been used for as long as modern medicine has been practiced. These agents are used to prevent the growth of bacteria in different formulas, canisters, containers, and utensils.
How to get bacteriostatic water out of a syringe?
Insert the needle tip into the sealed bottle of bacteriostatic water. Slowly extract the bacteriostatic water until the solution reaches the desired level visible in the syringe body. Gently remove the needle from the bacteriostatic water vial. Penetrate the medication’s vial, as gently as you can.
What is the unique characteristic of benzyl alcohol that provides a unique balance between pleasantries and efficacie?
The unique characteristics of benzyl alcohol that provide a unique balance between pleasantries and efficacies are what allows bacteriostatic water to be the ideal substance used for medication dilution prior to injection.
How to get bacteriostatic solution out of pipette?
Gently squeeze the pipette’s bulb before inserting the pipette tip into the bacteriostatic water. Gently insert the pipet tip into the bacteriostatic water. Very slowly relax your grip on the pipette’s bulb until the solution reaches the desired level visible in the pipette tip. Slowly bring the pipette tip out of the water while keeping ...
How long can you keep bacteriostatic water?
If your vial has been opened, you should make sure to use the water within a month.
How to get a pipette out of water?
Slowly bring the pipette tip out of the water while keeping a relaxed grip on the pipette’s bulb.
What to consider before giving bacteriostatic injection?
It’s best to consider what other medications are going to be in a patient’s bloodstream before giving a bacteriostatic water-rich injection. Consulting with a pharmacist, other doctors, or the FDA is suggested before mixing medications.
DESCRIPTION
This preparation is designed for parenteral use only after addition of drugs that require dilution or must be dissolved in an aqueous vehicle prior to injection.
CLINICAL PHARMACOLOGY
Sodium chloride in water dissociates to provide sodium (Na +) and chloride (Cl −) ions. These ions are normal constituents of the body fluids (principally extracellular) and are essential for maintaining electrolyte balance.
INDICATIONS AND USAGE
This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered.
CONTRAINDICATIONS
Due to the potential toxicity of benzyl alcohol in neonates, solutions containing benzyl alcohol must not be used in this patient population.
WARNINGS
Benzyl alcohol, a preservative in Bacteriostatic Sodium Chloride Injection, USP has been associated with toxicity in neonates. Data are unavailable on the toxicity of other preservatives in this age group. Preservative-free Sodium Chloride Injection should be used for flushing intravascular catheters.
PRECAUTIONS
Consult the manufacturer's instructions for choice of vehicle, appropriate dilution or volume for dissolving the drugs to be injected, including the route and rate of injection.
ADVERSE REACTIONS
Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation.
Do corticosteroids increase potassium?
Average and large doses of corticosteroids can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium. These effects are less likely to occur with the synthetic derivatives except when used in large doses. Dietary salt restriction and potassium supplementation may be necessary. All corticosteroids increase calcium excretion.
Can corticosteroids cause infections?
Patients who are on corticosteroids are more susceptible to infections than are healthy individuals. There may be decreased resistance and inability to localize infection when corticosteroids are used. Infections with any pathogen (viral, bacterial, fungal, protozoan, or helminthic) in any location of the body may be associated with the use of corticosteroids alone or in combination with other immunosuppressive agents.
Clinical Pharmacology
- Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Average normal adult daily requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production). Water balance is main…
Indications and Usage
- This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered.
Contraindications
- Due to the potential toxicity of benzyl alcohol in neonates, solutions containing benzyl alcohol must not be used in this patient population. Parenteral preparations with benzyl alcohol should not be used for fluid replacement. Parenteral preparations containing benzyl alcohol should not be used in epidural or spinal anesthesia procedures. Bacteriostatic Water for Injection, USP must b…
Warnings
- Benzyl alcohol, a preservative in Bacteriostatic Water for Injection, USP has been associated with toxicity in neonates. Data are unavailable on the toxicity of other preservatives in this age group. Where water is required for preparing or diluting medications for use in neonates, only preservative-free Sterile Water for Injection should be used. Intravenous administration of Bacter…
Precautions
- Do not use Bacteriostatic Water for Injection, USP for intravenous injection unless the osmolar concentration of additives results in an approximate isotonic admixture. Consult the manufacturer’s instructions for choice of vehicle, appropriate dilution or volume for dissolving the drugs to be injected, including the route and rate of injection. Inspect reconstituted (diluted or di…
Adverse Reactions
- Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation. If an adverse reaction does occur, discontinue the infusion, e…
Overdosage
- Use only as a diluent or solvent. This parenteral preparation is unlikely to pose a threat of fluid overload except possibly in very small infants. In the event these should occur, re-evaluate the patient and institute appropriate corrective measures. See WARNINGS, PRECAUTIONS and ADVERSE REACTIONS.
Dosage and Administration
- The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.
How Supplied
- Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Distributed by Hospira, Inc., Lake Forest, IL 60045 USA LAB-0977-2.0 Revised: 08/2019